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BASIG q1 > exam 10 > Flashcards

exam 10 Flashcards

1
Q

Malaria vaccine targets what

A

sporozoites

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2
Q

explain malaria life cycle

A
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3
Q

Babesiosis vector compared to malaria

A

barbesiosis vector is dear tick and in new england
has cross line rbc that looks like star
it is simular to falciparum
lyme dz
co infections

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4
Q

what is duffy Ag

A

antigen for vivax malaria that aftricans have. It increases resistance to malaria

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5
Q

what causes relapse of malaria

A

liver hypnozoites

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6
Q

Falciparum vs Vivax which one for the following
- black water
-rarely fatel
-no relapses
-Lysed rbc stuck to capillary limes
-cerebal malari
-duffy ag

A
  • black water - falcip.
    -rarely fatel -vivax
    -no relapses - falcip
    -Lysed rbc stuck to capillary limes - fal.
    -cerebal malari-falc.
    -duffy ag - vivax
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7
Q

what are maurers dots

A

found in rbc with falciprum malaria

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8
Q

what is the major pathophysiologic effect of rickettsia

A

increased microvascular permeability

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9
Q

R rickettsia
what dz:
dz sx:
reservoirs:
vector:
complication of dz:
Death?

A

Dz: rocky mtn spotted fever
Dz sx: rash on extremity first then
spread to trunk fever and
headache
CENTRIPETAL SPREAD

reseroirs: white foot deer mouse
Vector:
-american dog tick
-brown dog tick
-rocky mtn wood tick
Complication: myocarditis
Death? Yes

it is most common ricketsiosis in usa

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10
Q

R akari
what dz:
dz sx:
reservoirs:
vector:
Death?

A

what dz: Ricketsial pox
dz sx:red papule at site> cesicular
>eschar. then symptoms
similar to rocky mountain fever
reservoirs: house mouse
vector: house mouse mite
complication of dz:
Death? no, no tx needed

SELF LIMITED

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11
Q

What dz and bacteria causes centripetal spread of rash

A

R. rickettsi

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12
Q

R prowazekii
what dz:
dz sx:
reservoirs:
vector:
Death?

A

R prowazekii
what dz: Louse Typhus epidemic
1. Brill Zinnsner
-recurrent
- less severe and rarely fatal
2. sylvatic typhus
- small amt of cases
- no fatality
- vector: squirrel flea feces
-reservoir: Southern flying
squirrel

dz sx: HA fever centrifugal rash (rash trunk to limbs)
reservoirs: human
vector: louse
Death? yes so tx early to reduce risk

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13
Q

which ricketisa’s
mode is poop:
has centripetal spread of rash:
has cetrifugal spread of rash:
only in western hemisphere:
does not need tx:

A

which ricketisa’s

mode is poop:
R. Prowazekii
R. Typhi

has centripetal spread of rash:
R. Reckessii
has cetrifugal spread of rash:
R. Prowazekii
only in western hemisphere:
R. Reckessii
Does not need tx: R. Akari

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14
Q

R. Typhi
what dz:
dz sx:
reservoirs:
vector:
Death?

A

what dz: murine endemic typhus
dz sx: same as typhus tachypenia centrifugal spread
reservoirs: Opossums
vector: flea —- flea poop
Death? rare by 1 %

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15
Q

Reckettsiaceae
Gram: - or +
Tx:
Grow where:

Anaplasmataceae
Gram: - or +
Tx:
Grow where:

A

Reckettsiaceae
Gram: -
Tx: doxy
Grow where: cytoplasm or nucleus

Anaplasmataceae
Gram: -
Tx: doxy
grow: morulae membran bound structure

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16
Q

Reckettsiaceae or Anaplasmataceae

pleomorphic cocobacilli
escape phagosome
grow in wbc
necrotizing vasculitits

A

pleomorphic cocobacilli - both
escape phagosome - reck
grow in wbc - anaplasmat
necrotizing vasculitits - ricke

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17
Q

what is morulae and what species grows here

A

anaplasmataceae

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18
Q

E. Chaffeensis
what dz:
dz sx:
reservoirs:
vector:
Death?
Reckettsiaceae or Anaplasmataceae

A

E. Chaffeensis
what dz: human monocytic
ehrlichiosis HME
dz sx: non specific feaver headache
reservoirs: white tailed deer
vector: lone star tick
Death? low mortality rate
ANA

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19
Q

A. Phagocytophilum
what dz:
dz sx:
reservoirs:
vector:
Death?

A

what dz: human granulocytic anaplasmoisis HGA
dz sx: respiratory distrss
reservoirs: wild rodents
vector: black legged tick
Death? low

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20
Q

whats an exanthem

A

widespread rash usually on children

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21
Q

what are the 3 c’s and what dz is it linked to

A

Measles rubeola

coryza
cough
conjunctivitis

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22
Q

rubeola or rubella

koplik’s spots -
dx with serology -
infection in older children mild and inapparent -

A

koplik’s spots - buccal spots rubeola
dx with serology - rubeola
infection in older children mild and inapparent - rubella

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23
Q

what is congenital rubella syndrome CRS

A

infection in early pregnancy
heart problems
cataracts and glc
hearing loss

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24
Q

oral HSV %
genital Herpes %

tx

A

oral HSV 90%
genital Herpes 90%

Tx: acyclovir

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25
Q

what is VSV
tx

A

varicella zoster virus or chicken pox
tx acyclovir

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26
Q

why is asprin not recommended for VSV

can you take after vaccine?

A

reyes syndrom hepatitis encephalitis risk

dont take with vaccine

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27
Q

dz underappreciated risk - contact with small children

A

CMV

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28
Q

percent of people past the age of 85 getting shingles \

can they pass it to someone else

A

50%

yes they can pass it to nieve pt

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29
Q

vaccines for what

mmr

varivax

shringrix

A

mmr - measles

varivax- chicken pocks

shringrix - shingles

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30
Q

what dz shows maculopapular rash?
what other sx?
how to tx?

A

what dz shows maculopapular rash? parvo
what other sx? CT issues like arthritis arthralgia sometimes with no concurrrent sx
how to tx? NSAID

31
Q

Borrelia and leptospira are part of phylen

A

spirochaetes

32
Q

what is the primary agent of lym dz in n america

what is the primary agent of soft tick relapsing fever in N america

primary agent for louse borne relapsing fever

which is not zoonotic

A

Lyme _ B.Burgdorferi

Soft tick relapsing fever _B. Hermsii

Louse bourn relapse _ B. Recurrentis not zoonotic

33
Q

B. Burgdorfi
resevoir -
vector -
sx -
tx-

A

resevoir - rodent
vector - black legged tick
sx - erythema migrans (bulls eye rash)
tx- doxy

34
Q

when are lab test needed for B. Burgdorfi

A

early disseminated and late lyme dz

IF and only If ….
signs and sx there
hx of tick

ELISA 1 postive then proceed with elisa 2

35
Q

B. Hermsii
reservoir :
vector :
tx:
dz:

A

B. Hermsii
reservoir : ground squirrel
vector : soft tick or ornithodorus hermsi
tx: tetracyclin
dz: soft tick relapsing fever

36
Q

what pathogen causes infectious mononucleosis IM HHV4

A

EBV

37
Q

B. Recurrentis
reservoir :
vector :
tx:
dz:

A

B. Recurrentis
reservoir :humans
vector : lous
tx: tetracycline
dz: louse borne relapse

38
Q

Hermsi or recurrentis

singel dose for tx
high moratility
clean close prevention
west of missipi
north america distribution

A

singel dose for tx - recu
high moratility - recu
clean close prevention - recur
west of missipi - hermsi
north america.- both

39
Q

Orchitis in men
and
oophoritis in women

is compliation of what dz

A

mumps

40
Q

how to dx hermsi or recurrentis for recurrent fever

A

Elisa

41
Q

2 spirochetes

A

borellia or leptospira interogens

42
Q

what is jarisch-herheimer

A

complication of borellia causing relapsing fever (80% Louse born relapsing fever) or leptospirosis

after given antibiotis

spirochetes die and release ag casuing feer cills tachy cardia hypotension

43
Q

when you thin Borellia think

zoonotic spirochete

A

2 fever and lyme dz

leptospira interrogans

44
Q

what pathogen

-is shed in the urine
-spread by lakes rivers and domestic live stock

A

leptospira interrogeans
it is zoonotic

45
Q

most common opportunistic virus for HIV

A

CMV

46
Q

what is the major cause of morbitity and death of HIV and transplant pt

A

Cytomegalovirus (CMV)

47
Q

Leptospirosis stages of dz

A

1: HA fever chills if it doesnt resolve go to 2 part
2: menigitis
renal
liver failure
conjunctivitis

48
Q

what is owl eye and what dz causes

A

Charecteristic CPE with massive cell enlargment - Cytomegalovirus

49
Q

remember most VFH ( viral hemorrhagic fever ) is zoonotic

what are its resevior

A

animal or arthropods

50
Q

what is a common early sx of VHF

-what important info for dx

-tx:
-prevention:
-virus agent

A

what is a common early sx of VHF
* rash can lead to organ failure

-what important info for dx
*travel hx
-tx:
*supportive care
-prevention:
*isolation
-viral agent
*ebola

51
Q

HIV

has higher titer viremia @ ____
and again when ______

In terms of infection risk
highest risk
elevated risk

A

has higher titer viremia @ 3- 9 weeks
and again when it turns into aids

most infections at early infection before Ab limit virus

In terms of infection risk
highest risk - first 5 mo ** and when HIV test is still negative
elevated risk - 15 mo before death

52
Q

how do they test for HIV in blood donations

A

PCR checks for viral Ag

53
Q

what test established latency in oropharynx and wbc

A

EBV

54
Q

what dz causes splenomegaly or ruptur

A

ebv

55
Q

EBV
Dx -

A

heterophile antibodies (they are transient)

monospot test agglutination of horse RBS

younger may not have + monospot test

56
Q

CMV

significant for who

A

significan in immunosupressed pt and congenital infection

most are subclinical

primary dz in compromised host s worst situation

57
Q

what dz if patient has these results
Heterophile ( - )
herterophile (+)

IgM serology
owl eye cell

A

Heterophile ( - ) : CMV
herterophile (+) : EBV

IgM serology - CMV
owl eye cell - CMV

58
Q

CMV pt are usuall (older/younger) than infectious mono

A

older

59
Q

Mumps is infection of what

complication

A

salivary glands causing pain swelling and fever

60
Q

what is the infective stage of Trypan. Brucei

leishmania spp

A

trypan tripomastigote

leishmani spp - promostogote

61
Q

what do kinetoplast help

A

dx leishmania in lab

62
Q

Trypanosoma ruicei
dz :
vector:
infective stage :
cool feature:
life cycle:

A

Trypanosoma ruicei
dz : african sleeping sickness
vector: tsetse fly
infective stage :tripomastigote
cool featureL evades immune system with variant surface glycoproteins VSG

63
Q

name two subspecies of T. Brucei

which one is easily seen
which one is slow but chronic
which one is fast but acute
which one has primary resecior of humans … animal
heart rythme changes and seizures

A
  1. Gambiense (west african )
    -slow chronic
    -human
    - heart changes
    - seizures
  2. Rhodesiense ( east africa)
    -easily seen
    -rapid but acute
    -animals
64
Q

Trypanosoma Cruzi
Dz
Vector
Life cycle

dx acute
dx chronic

sx acute

A

Trypanosoma Cruzi
Dz - chagas
Vector - tiatomine kissing but
Life cycle -

dx with blood smear

dxacute Trypomsatigote
dx chronic amasigote

sx stages
acute chagoma where they enter
skin
romana signs swelling

65
Q

leishmania
vector:
infectious form:
life cycle:
types:

A

leishmania
vector: sandfly
infectious form: promatigote
life cycle:
types:
1. cutaneous
2. Mucocutaneous
3. visceral

66
Q

most common form of leishmaniasis
when does it develope
sx

A

cutaneous
weeks to months
skin lesions

67
Q

what form of leishmaniasis occurs years to decades and what sx

A

mucocutaneous

nasal sx

68
Q

leismania can affect what internal organ

A

spleen

69
Q

snails are the first intermediate hose of what

A

trematotodes flukes and shitosome

70
Q

___vector____
Lymphatic filariasis:
schitosome trematodes:

___tx ___
Lymphatic filariasis:
schitosome trematodes:

__site ___
Lymphatic filariasis:
schitosome trematodes:

__epidem___
Lymphatic filariasis:
schitosome trematodes:

_____ sx_____
Lymphatic filariasis:
schitosome trematodes:

____ which one has feces and urine mode?___

A

___vector____
Lymphatic filariasis: flies mosquitos
and domestic animals
schitosome trematodes: snail

___tx ___
Lymphatic filariasis:: DEC
diethylcarbamazine
schitosome trematodes:
praziquntel

__site ___
Lymphatic filariasis: subcut skin eye
schitosome trematodes:
urinary(haematobium)
mesentary (mansoni)

__epidem___
Lymphatic filariasis: sub tropics and
tropics
schitosome trematodes:sub tropics
and tropic FRESH WATER

_____ sx_____
Lymphatic filariasis: edema
elephantitis chyluria (lymph in
blood)
schitosome trematodes: intestine
pain increas in liver size or blood
in urine (hematuria)

____ which one has feces and urine mode?___. Shchistosomiasis

71
Q

what form of pathogen exists snail

A

cercarial larvae

72
Q

which worm has compication of brain damage and lung

A

schitosome trematodes

73
Q

african eye worm

A

loiasis loa loasub conj migration tz with DEC

BASIG q1 (11 decks)

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