Exam 5: Neuro Disorders Flashcards
Stroke
Etiology: Endothelial injury, Arteriosclerosis, Hypertension, Hyperlipidemia, Diabetes, Atrial Fibrillation, Overweight/obesity, Previous TIA, Sickle cell, Tobacco use, Alcohol use, Physical inactivity, Oral contraceptives, Family history, Age/gender
CM: Think FAST; sudden AMS or HA
Diagnostics: History and presentation, LOC, GCS, CT/MRI, NIHSS, Opthalmoscopic exam
FAST
F acial drooping
A rm weakness
S peech difficulties
T ime = brain
Intracerebral hemmorhagic stroke
Intracerebral (*most common type of hemorrhagic stroke)
Etiology: HTN, trauma, arteriovenous malformation (AVM)
Ruptured of cerebral blood flow bleeding into the brain -> adjacent brain is contused, swollen, and incomplete return of function
Subarachnoid hemorrhagic stroke
Etiology: HTN, trauma, aneurysm, cigarette smoking, use of high estrogen oral contraceptives, excessive alcohol intake, use of illegal drugs
Ruptured vessel in subarachnoid space
Interferes with cerebral spinal fluid (CSF) reabsorption, hydrocephalus results.
Leads to vasospasms
Patho of ischemic stroke
- Thrombus or embolus that lodges in a cerebral artery and blocks blood flow to the brain tissue
- Margins of infarct blood vessels dilate
- Increased edema surrounding ischemia
- Edema leads to further perfusion problems
not always activity dependent - can happen during sleep
Patho of hemorrhagic stroke
- Increased ICP
- Ischemic cellular response
- Cerebral edema
- Compromised cerebral perfusion pressure
- Possible herniation-death*
Right sided vs left sided deficits
TIA
<24 hours of symptoms resolve NO INFARCT (blood flow re-established before)
Brief episode of neurological dysfunction
Warning sign of potential stroke
TBI
alteration in brain function or other evidence of brain pathology caused by an external force
sudden physical damage to the brain
Focal and diffuse patterns of axonal injury
DAI occurs when the brain moves back and forth in the skull, hitting into the cranial bone, as a result of coup-contrecoup injury -> mild to severe depending on length of coma and deficits
Epidural hematoma
Serious head injury w/hx trauma: caused due to skull bone fracture
Bleeding epidural space
Arterial based: FAST (“worse HA of life”)
transient loss of consciousness →”lucid interval“→ rapid decline
Delayed in recognition causes death
Subdural hematoma
Most common type of traumatic intracranial hematoma w/hx of trauma
Bleeding below the dura matter and above the arachnoid membrane
The subdural hematoma occurs from tearing of bridging veins located in the subdural space.
Venous based: slow
Acute within 72 hours, subacute can take up to 7 days to accumulate
Occur in the elderly, anticoagulants, alcoholics
Concussions
Trauma-induced AMS that may or may not involve LOC (mild TBI)
Patho: Physiological disruption in brain function caused by traumatic forces
Simple: Resolve few hours to 10 days
Complex: prolong loss of consciousness, prolonged impairment months to years, seizures
Altered LOC, HA, Dizzy, lack of coordination , Imbalance, Amnesia, Vomiting may suggest elevated ICP
Seizures
◦single event of abnormal discharge that results in an abrupt and temporary altered state of cerebral function
focal/partial or generalized
Patho: Imbalance between excitation and inhibition of CNS
Need excitable neurons
Increase in excitatory glutaminergic activity for recurrent connection to spread discharge
Reduction in activity of the normal inhibitory (GABA) projection
Risk factors/causes: head trauma (young), stroke (elderly), genetics
Diagnosed: history and physical and EEG
Absence seizure
common in children, interrupt consciousness characterized by a blank stare