Exam 4 Flashcards
Antigen
A toxin or other foreign substance that induces an immune response in the body especially the production of antibodies
Autoimmune disease
A disease in which the body produces antibodies that attack its own tissues leading to the deterioration and in some cases to the distraction of such tissue
Innate immunity
A type of immunity that is non-specific and response to all foreign material
Adaptive immunity
A specific type of immunity that responds to one antigen memory
Two types of immunity?
- Innate immunity
2. Adaptive immunity
Mechanical and chemical barriers that protect the body
- skin
- mucus membranes
- stomach acid
- flow of tears
- Flow of urine
- coughing and sneezing
Skin
Skin is a barrier for entry of bacteria and viruses
Mucus membranes
Mucous membranes trap particles and move them to the surface
Stomach acid
Stomach acid kills bacteria and viruses stomach acid has a low pH
Flow of tears
The flow of tears removes bacteria and viruses
Flow of urine
The flow of urine removes bacteria and viruses
Coughing and sneezing
Coughing and sneezing and removes bacteria and viruses
Interferon
And interferon is a protein released by animal cells usually in response to the entry of a virus that has The property of inhibiting virus replication
How does a virus reproduce?
- The virus attaches to a cell
- The virus injects its DNA into the cell
- The cell begins to produce viruses
- when the cell becomes full of viruses it bursts
- The viruses then infect New cells
How interferons work?
The infected cell makes interferons to signal the neighboring cells to start producing anti-viral proteins
Where do white blood cells develop?
White blood cells develop in red bone marrow
Phagocytes
A type of White blood cell that Engulfs bacteria also known as big eater cells
White blood cells produce what?
- Antibodies
2. Histamines which signal infection
Types of white blood cells
- neutrophils
- monocytes (macrophages)
- basophils and mast cells
- Eosinophils
- natural killer cells
Neutrophils
Neutrophils are small phagocytes 125 billion are dumped into our intestines daily. Neutrophils migrate to infected tissue and release lysozymes which are enzymes
Monocytes (macrophages)
Monocytes are large Phagocytes which migrate to infected tissue. Monocytes produce complement proteins and interferons they are found in the lymph nodes
Basophils and mast cells
When a mast cell is circulating it is called a basophil when a mast cell is down in the tissue it is called a mast cell. Mast cells produce histamines another signals
Eosinophils
Eosinophils migrate to tissues and breakdown histamines. They also secrete enzymes to kill parasites usually larger parasites like worms
Natural killer cells
Natural killer cells are also called lymphocytes they recognize cancer and virus-infected cells. They sit next to an infected sell and release chemicals to Lyse the cell
Steps to inflammatory response activation
- The tissue is damaged and bacteria enter
- Chemical signals and histamines are released by basophil mast cells
- Chemical signals lead to increased blood flow, chemotaxis and, vascular permeability
- neutrophils and other white blood cells like macrophages migrate to the injury site and remove pathogens by Phagocytosis
- macro phages secrete hormones called cytokines that attract immune system cells to the site and activate cells involved into tissue repair
- Inflammatory response continues until the foreign material is eliminated and the wound is repaired
Inflammatory response feedback loop
- White blood cells come to injury site
- White blood cells destroy bacteria until bacteria are gone
- If bacteria are still present more chemical signals are sent out to attract more white blood cells until no bacteria are left
- if some bacteria remain the cycle repeats until all bacteria are gone
Functions of the lymphatic system
- Fluid balance- 10% of fluid from the blood returns as lymph
- Fat absorption and transport- starts transport from intestine to veins
- Immune defense- fights disease and infection
Lymph vessels
Lymph vessels are found near arteries and veins. Lymph vessles have valves.
Lymphatic ducts
- Thoracic duct
- Jugular trunk
- Subclavian trunk
- Bronchomediastinal trunk
Thoracic duct
Drains lymph from lumbar trunks and, lower body lumbar region and legs
Jugular trunk
Drains lymph from head and neck
Subclavian trunk
Drains lymph from arms and superficial thoracic
Bronchomediastinal trunk
Drains lymph from thorax
Parts of a lymph node
- Afferent duct
- Nodule
- Germinal center
- Efferent duct
- Capsule
- Trabecula
- Diffuse tissue
- Medullary sinus
- Cortical sinus
Capsule
The capsule of a lymph node is the outer layer which is made of dense irregular connective tissue
Trabeculae
Made of dense irregular connective tissue you seen as light colored open spaces
afferent flow
Flow into the lymph node
Efferent flow
Flow out of the lymph node
Sinuses
Open areas for flow of lymph
Where are macrophages found in lymph nodes?
Lining the sinuses
Where are lymphocytes found in a lymph node?
In the lymphatic nodules
What is the purpose of the germinal center of the lymph node?
It serves as the site of mitosis for lymphocytes
Medullary cord
Is made of diffuse lymphatic tissue
Functions of the immune system?
- Recognition of self; kill everything else
- Innate immunity: non specific immunity, responds to all foreign material
- Adaptive immunity; specific responds to one antigen memory
unencapsulated lymphatic tissue
Lymphatic tissue that is not surrounded by connective tissue and
Diffuse lymphatic tissue
Loose collection of lymphatic tissue
Lymphatic nodules
Dense arrangement of the lymphatic tissue
Tonsils
Large collection of nodules
Macosa associated lymphoid tissue is found in the lining of
Digestive system
Reproductive system
Urinary system
Respiratory system
Types of tonsils
- Pharyngeal tonsils- found on roof of mouth
- Palatine tonsils- found on sides of mouth
- Lingual tonsils- found on back of tongue
Encapsulated to lymphatic tissue
Lymphatic tissue that is surrounded by connective tissue
What are the three different encapsulated lymphatic tissues?
- Lymph nodes
- spleen
- Thymus
What is the function of Lymph nodes?
Lymph nodes filter bacteria from lymph
What are the three functions of the spleen?
- Destroys old red blood cells
- Part of the immune system
- Small blood reservoir
What is the function of the thymus?
Site of T-lymphocyte maturation
What is the area of the spleen where the arteries and veins attach?
Hilum
What are the components of the spleen?
- Artery
- Vein
- White pulp
- Red pulp
- Trabecula
- Capsule
White pulp
Contains lymphatic nodules
Red pulp
Contains venous sinuses and has open flow
Splenic cord
Contains reticular cells, macrophages and removes old red blood cells
Fast flow
Directly from arteries into Venous sinuses. About 88% of flow in spleen takes only a few seconds
Intermediate flow
Percolates through splenic cord. 10% of flow and spleen takes a few minutes
Slow flow
Percolates through splenic cord 2% of flow in spleen takes an hour
Components of the thymus
- Capsule
- Trabecula
- Cortex
- Medulla
Types of lymphocytes
- Natural killer cells
- B lymphocytes
- T lymphocytes
Natural killer cells
Attack and kill cells displaying signs of not being part of the organism
B Lymphocytes
Responsible for antibody production
T lymphocytes
Attack cells showing specific antigens
What is Costimulation?
In some immune responses a B cell or a T-cell becomes activated when an antigen or nonself cell binds to an activation then initiates proliferation and most immune responses however activation requires the presence of a Costimulator
What is the cytokine?
Any of a number of substances such as the interferon interleukin and growth factors that are secreted by certain cells of the immune system and have an effect on other cells
Process of costimulation
- A bacteria or virus enters the body
- Proteins combine with MHC II
- Proteins are displayed on the surface
- antigen persists
- Helper T cells proliferate
- The cloned T cells recognize the antigen
Antibody production
- Clone line of B cells proliferate
2. And produce antibodies to a specific antigen
Primary response
The response that the immune system displays when first exposed to an antigen memory cells are created and antibodies are created for the next exposure
Secondary response
An integrated bodily response to an antigen especially one mediated by lymphocytes and involving recognition of antigens by specific antibodies or previously sensitized lymphocytes. Secondary responses are generally stronger and faster then primary responses
What are the functions of the digestive system?
- Ingestion
- Secretion
- Mixing and propulsion
- Digestion
- Absorption
- Defecation
Ingestion
Eating and drinking
Secretion
Cells produce products and dump them into the lumen
Mixing and propulsion
Also known as peristalsis
What are the two types of digestion?
- Mechanical
2. Chemical
Mechanical digestion
Chewing and mixing
Chemical digestion
Enzymes break down food molecules
Absorption
Taking in monomers
Monomer
A simple molecule of relatively low molecular weight capable of reacting to form by repetition a polymer. some basic unit of a molecule either the molecule itself or some structural or functional subunit of it. Basic nutritional unit of a food item
Defecation
Eliminating waste
Components of the digestive system
- Mouth
- Salivary glands
- Pharynx
- Esophagus
- Stomach
- Liver
- Pancreas
- Gallbladder
- Large intestine
- Small intestine
- Cecum
- Appendix
- Rectum
- Anus
Abdominal regions
- Right hypochondriac region
- Right lumbar region
- Right iliac/inguinal region
- Epigastric region
- Umbilical region
- Hypogastric/pubic region
- Left hypochondriac region
- Left lumbar region
- Left iliac/inguinal region
Parts of the peritoneum
- Falciform ligament
- Parietal peritoneum
- Greater omentum
- Bursa
- Small instestine
- Urinary bladder
- Corrinary ligament
- liver
- Lesser omentum
- stomach
- Pancreas
- Duodenum
- Mesocolon
- Transverse colon
- Mesentary
- Rectum
Layers of the G.I. tract
- Lumen
- Mucosa
- submucosa
- Muscularis
- Serosa
Components of the Mucosa
- Epithelium: interlining toward Lumen mucous membrane
- Lamina Propria: areolar connective tissue, lymphatic connective tissue
- Muscularis mucosa: in layer of smooth muscle
Components of submucosa
- Areolar CT
- Blood vessels, nerves, lymphatic vessles
- Connects mucosa to muscles
- Contains some glands in intestine
Components of muscularis
Contains thick layers of muscle contains skeletal muscle found in mouth pharynx and esophagus smooth muscle which is found in a esophagus stomach and intestines
Components of serosa
Contains areolar connective tissue and epithelium also has serous membrane continues with membranes that suspend the organs
Components of the mouth
- Superior lip
- Fauces
- Tongue
- Gums
- Vestibule
- Inferior lip
- Cheek
- Uvula
- Soft palate
- Hard palate
- Teeth
3 types of salivary glands
- Parotid
- Sublingual
- Submandibular
Saliva
Contains water mucous digestive enzymes it lubricates the food and starts chemical digestion
Parotid glands
Near ear, makes watery solution that contains high amounts of the enzyme amylase
Submandibular glands
Located inside mandible creates thick mucus with some Amylase
Sublingual glands
Located below the tongue synthesizes very thick mostly mucousy saliva
Lingual glands on tongue
Creates lingual lipase
Parts of the tooth
- Enamel
- Gingiva
- Dentin
- Pulp
- Root canal
- Cementum
- periodintal ligaments
- Bone
- Apical foramen
- Crown
- Neck
- Root