Exam 4

Question 1

a functional decrease in what, contributes to depression?

Answer 1

monoamine transmission

Question 2

what is the primary mechanism of action of most antidepressant drugs?

Answer 2

an increase in monoamine neurotransmission

Question 3

an enzyme that degrades dopamine, NE, and epinephrine

Answer 3

monoamine oxidase

Question 4

what does blocking monoamine oxidase lead to?

Answer 4

increased monoamine levels = effective antidepressant

Question 5

NE and dopamine contain which type of monoamine oxidase?

Answer 5

MAO-A and MAO-B

Question 6

5-HT (serotonin) contains which type of monoamine oxidase?

Answer 6

MAO-A

Question 7

where is MAO-A also distributed?

Answer 7

liver and gut

Question 8

symptoms that appear to reflect an addition to or an excess of normal functions; hallucinations, delusions, and disorganized thinking

Answer 8

positive symptoms

Question 9

symptoms that are absent from our normal behavior (loss of function); flat affect, social withdrawal

Answer 9

negative symptoms

Question 10

symptoms of altered thinking, concentration, and memory

Answer 10

cognitive symptoms

Question 11

pathway that regulates emotion and pleasure, and blocking this reduces positive symptoms

Answer 11

mesolimbic pathway

Question 12

pathway that has cortical dopamine that regulates cognitive function, so a decrease in DA will lead to negative and cognitive symptoms

Answer 12

mesocortical pathway

Question 13

pathway that controls movements

Answer 13

nigrostriatal pathway

Question 14

attributed to the loss of nigral DA neurons

Answer 14

parkinson’s disease

Question 15

pathway that inhibits prolactin release since D2 blockade can lead to hyperprolactinemia

Answer 15

tuberoinfundibular pathway