Cholinergic Pharmacology Flashcards
which neurons release acetylcholine?
parasympathetic postganglionic neurons
ALL preganglionic neurons
ALL somatic neurons
what does acetylcholinesterase do?
degrade acetylcholine
what do AChE inhibitors lead to?
acetylcholine accumulation in the neuromuscular junctions and synapses
what is the principle cholinergic receptor in skeletal muscle and autonomic ganglia - both sympathetic and parasympathetic
nicotinic receptors
which cholinergic receptors are ligand-activated cation channels?
nicotinic
which cholinergic receptors are G-protein coupled?
muscarinic
what are 3 nicotine central effects?
arousal
increase mental performance
dopamine
when nicotine stimulates nicotinic receptors on the adrenal medulla, what does it release?
epinephrine
what are 2 nicotine peripheral effects?
increase HR
increase BP
which nicotinic receptor works at the neuromuscular junction?
a1 - b1
which nicotinic receptor works at all autonomic ganglia?
a3 - b4
which nicotinic receptor works throughout the brain?
a4 - b2 - a7
why are Nn ganglion nicotinic receptor drugs no longer used for regulating autonomic functions?
they are nonspecific - block sympathetic AND parasympathetic ganglia
Nm effects at muscles are useful for what?
paralysis during surgery
Nn effects at the brain are useful for what? (3)
smoking cessation
analgesics
Alzheimer’s
