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Pharmacology > Adrenergic Pharmacology > Flashcards

Adrenergic Pharmacology Flashcards

1
Q

what do adrenergic neurons contain?

A

norepinephrine

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2
Q

where is norepinephrine released from?

A

postganglionic sympathetic neurons

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3
Q

which family does NE belong to?

A

catecholamines

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4
Q

describe the steps in catecholamine synthesis (3)

A

phenylalanine converted to tyrosine
tyrosine converted to L-DOPA
L-DOPA converted to dopamine

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5
Q

what is dopamine chemically related to?

A

NE

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6
Q

where is Epi synthesized from?

A

adrenal glands

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7
Q

which enzyme is responsible for NE degradation in nerve terminals?

A

monoamine oxidase

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8
Q

which enzyme is responsible for degrading circulating NE?

A

catechol-O-methyl transferase

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9
Q

what is the principle metabolite of Epi and NE that is secreted in the urine?

A

VMA

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10
Q

what do adrenergic agonists mimic?

A

sympathetic nervous system

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11
Q

which receptors produce excitation?

A

alpha 1
beta 1

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12
Q

which receptors produce inhibition?

A

alpha 2
beta 2

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13
Q

what do alpha 1 adrenergic receptors increase?

A

Ca2+

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14
Q

where do alpha 1 adrenergic receptors primarily act?

A

smooth muscle

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15
Q

what is the main function of alpha 1 adrenergic receptors?

A

vasoconstriction of blood vessels

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16
Q

what do alpha 2 adrenergic receptors decrease?

A

cAMP

17
Q

where do alpha 2 adrenergic receptors primarily act?

A

nerve terminals - CNS and PNS

18
Q

what is the main function of alpha 2 adrenergic receptors?

A

decrease neurotransmitter release

19
Q

what do beta 1 adrenergic receptors increase?

A

cAMP

20
Q

where do beta 1 adrenergic receptors primarily act?

A

in the heart

21
Q

what do beta 2 adrenergic receptors increase?

A

cAMP

22
Q

where do beta 2 adrenergic receptors primarily act?

A

lungs
GI
smooth muscle

23
Q

NE is devoid of _____ activity at low doses

A

beta 2

Pharmacology (13 decks)

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