Exam 3: Vitamins Flashcards
Do vitamins yield energy?
NO
Fat soluble vitamins
A, D, E, K
Water-soluble vitamins
B vitamins and C vitamins
What are phytochemicals??
Nonnutritive substances in plant based foods that appear to have disease-fighting properties
What is a coenzyme?
A small molecule that combines with an enzyme to make it active
Thiamine (What is it?)
Vitamin B1
Thiamine (B1) Function
Coenzyme in energy metabolism
Nerve functioning related to muscle actions
Thiamine Deficiency
Ataxia (inability to walk properly)
Tachycardia
Thiamine Toxicity
Nontoxic
Thiamine Sources
Meat, milk, breads, cereals
Riboflavin (What is it?)
Vitamin B2
Riboflavin Function
Coenzyme in energy release
VERY light sensitive
Riboflavin Deficiency
Ariboflavinosis
Cheilosis (sores), glossitis, seborrheic dermatitis
Riboflavin Toxicity
Nontoxic
Riboflavin Sources
Dairy, cereal, nuts, milk
Niacin (What is it?)
Vitamin B3
Niacin Function
Coenzyme for many enzymes (especially energy metabolism)
What is niacin critical for?
Glycolysis and TCA cycle
What is the precursor of Niacin?
Amino acid Tryptophan
Niacin Sources
Protein-containing foods
Niacin Deficiency
Pellagra
Symptoms of pellagra
3Ds
Diarrhea
Dermatitis
Dementia
Who is at risk for pellagra?
Excessive alcohol consumption, malabsorption
Niacin Toxicity
Causes vasodilation and flushing affect
Pyridoxine (What is it?)
Vitamin B6
Pyridoxine Function
Acts as coenzyme in metabolism of amino acids and proteins
-Hemoglobin synthesis
Pyridoxine Deficiency
Rarely occurs alone
Pyridoxine Toxicity
UL 100 mg / day
Folate
B Vitamin
Synthetic folate is called…
Folic acid
Folate Functions
-Coenzyme in one-carbon transfer during metabolism
-Required for synthesis of amino acids, DNA and RNA
Other functions….
Folate Sources
Leafy green vegetables, legumes, fruit, fortified cereals
What is folate affected by?
Heat, oxidation, UV light, processing, long storage
Folate Deficiency
Megaloblastic anemia, glossitis, diarrhea, absentmindedness..
Folate Toxicity
UL 1000 mcg folic acid
Cobalamin (What is it?)
B12
Functions of Cobalamin
- Modifies folate coenzymes to active forms
- Metabolism of fatty acids and amino acids
- Myelin sheath
Cobalamin Deficiency
Usually secondary, results in..
-Megaloblastic anemia or pernicious anemia
Cobalamin Toxicity
Unknown
Cobalamin sources
ONLY animal derived foods
What does absorption of Cobalamin require?
Intrinsic factor produced by stomach mucosa
Cobalamin Sources
Only animal derived foods
Cobalamin Toxicity
Unknown
Vitamin C Functions
ANTIOXIDANT and coenzyme
Collagen formation
Wound healing
Vitamin C Deficiency
Scurvy
Poor wound health, gingivitis, inadequate tooth and bone growth / maintenance
Vitamin C Toxicity
UL
Cramps, diarrhea, kidney stones
Biotin
Important role in metabolism (CHO, fat, and protein)
Pantothenic Acid
Part of coenzyme A for metabolism
Choline
Synthesis of acetylcholine and lecithin (phospholipid)
Vitamin A Functions
Maintains skin and mucous membranes Vision Bone growth Immune System Reproduction
Vitamin A deficiency
Xerophthalmia: Night blindness
Immune system impaired
Limited bone growth
Vitamin A sources (2 types)
Natural, pre-formed
Precursor carotenoids
Natural preformed vitamin A sources
Whole milk, butter, liver, egg yolks, fatty fish
Precursor carotenoids vitamin A
Deep green, yellow and orange fruits and vegetables
Vitamin A toxicity
Only from pre-formed vitamin A
What is the precursor to Vitamin A?
Beta-carotene
Excess beta-carotene results in…
Orange tinted skin (Carotenemia)
Vitamin D function
Intestinal absorption of calcium and phosphorus
Affects bone mineralization and mineral homeostasis (calcium)
Vitamin D sources
Body synthesis (sun) or dietary sources
Dietary sources of vitamin D
Animal-related foods
Vitamin D Deficiency
Children: Rickets
Adults: Osteomalacia
Vitamin D Toxicity
Hypercalcemia and hypercalciuria
Vitamin E function
Antioxidant
Vitamin E Deficiency
Primary is rare
Secondary occur in individuals unable to absorb fat normally
Vitamin E toxicity
Supplementation contraindicated with anticoagulant drugs
Vitamin K Function
Cofactor in synthesis of blood-clotting factors
Protein formation in bone, kidney, plasma
Vitamin K Sources
Synthesized by bacteria in GI tract
Dark green leafy vegetables, less in cereals
Vitamin K Deficiency
Inhibits blood coagulation
Why are newborns given an inter muscular injection of vitamin K?
To prevent hemorrhagic disease
Vitamin K Toxicity
Excess amounts of supplements decrease effectiveness of anticoagulant medications