Exam #3: Rheumatology Flashcards
What condition involves malar rash, discoid rash, polyarthritis, mucosal ulcers, renal issues?
SLE
What three findings will be + with SLE?
+Anti-dsDNA (+ if acute)
+Anti-Sm (+ if acute OR chronic)
+ANA
What condition involves:
+Anti-dsDNA (+ if acute)
+Anti-Sm (+ if acute OR chronic)
+ANA
SLE
How can you differentiate acute vs. chronic SLE?
ACUTE: +Anti-dsDNA, +Anti-Sm
ACUTE OR CHRONIC: +Anti-Sm
What ANA subtype is associated with VTE?
Antiphospholipid Ab
- Antiphospholipid Syndrome
What condition involves morning stiffness 1+ hours; redness/swelling of PIP and MCPs (DIPs spared), ulnar deviation at MCPs?
RA
What joints are affected, and which are spared with RA?
- PIP and MCPs affected
- DIPs spared
What three findings will be + with RA?
+Anti-CCP (high specificity)
+/- RF (moderate specificity)
+ANA
What condition involves:
+Anti-CCP
RA
What condition involves speckled pattern on immunofluorescent stain?
RA
What condition involves sicca complex: fatigue, dry mouth/eyes, diffuse joint aching?
Sjogren Syndrome
What condition involves:
+Anti-Ro/SSA
+Anti-La/SSB
+ANA
Sjogren Syndrome
What three findings will be + with Sjogren Syndrome?
+Anti-Ro/SSA
+Anti-La/SSB
+ANA
What condition involves proximal aching/stiffness esp. in morning/prolonged sitting; subjective weakness, normal strength?
Polymyalgia Rheumatica (PMR)
What condition is improved with steroids, age 55+ years?
Polymyalgia Rheumatica (PMR)
What finding will be + if Polymyalgia Rheumatica (PMR)?
ESR
What condition presents with elevated ESR? What other condition might present with an elevated ESR?
Polymyalgia Rheumatica (PMR) - Also associated with Giant Cell Temporal Arteritis
What condition involves generalized arthralgias and myalgias, “foggy” mind; normal PE; NORMAL LABS?
Fibromyalgia
What condition involves low back pain, progressive stiffness (worse in morning and with rest, better with activity)?
Ankylosing Spondylitis (AS)
What condition involves bamboo spine, sacroiliitis; association with plantar fasciitis?
Ankylosing Spondylitis (AS)
What finding will be + with Ankylosing Spondylitis (AS)?
+HLA-b27
What condition involves:
+HLA-b27
Ankylosing Spondylitis (AS)
What condition involves CREST, and what does this stand for?
LIMITED Systemic Sclerosis
- Calcinosis
- Raynaud’s
- Esophageal dysfunction
- Sclerodatyly
- Telangiectasias
What two findings will be + with LIMITED Systemic Sclerosis?
+ACA
+ANA
What condition involves:
+ACA
+ANA
LIMITED Systemic Sclerosis
What two findings will be + with DIFFUSE Systemic Sclerosis?
+Anti-Scl-70 Ab
+ANA
What condition involves:
+Anti-Scl-70 Ab
+ANA
DIFFUSE Systemic Sclerosis
What three findings will be seen with Gout?
- MSU
- Negatively birefringent
- Needle-shaped
What three findings will be seen with Pseudogout?
- CPPD
- Positively birefringent
- Rhomboid-shaped
What condition involves MSU, negatively birefringent, needle-shaped?
Gout
What condition involves CPPD, positively birefringent, rhomboid-shaped?
Pseudogout
What is the most severe risk associated with an Arthrocentesis?
SEPTIC JOINT
What test is used to evaluate joint effusion or inflammation?
Arthrocentesis
What are four indications for performing an Arthrocentesis?
- New onset/acute monoarthritis
- Suspected crystal arthritis
- Suspected infection/septic arthritis
- Unexplained swelling
What three characteristics are seen with NORMAL Joint (Synovial) Fluid?
- Viscous
- Clear (egg white consistency)
- Acellular
How can you differentiate inflammatory from Non-inflammatory joint?
- Inflammatory = 2000+ WBCs
- Non-inflammatory = less than 2000 WBCs
If joint fluid is opaque, what is this indicative of?
Septic joint
If joint fluid is yellow, what is this indicative of (2)?
- Inflammatory joint
- Non-inflammatory joint
If joint fluid is yellow/green, what is this indicative of?
Septic joint
If joint fluid has LOW viscosity, what is this indicative of?
Inflammatory joint
A joint is _____ if 100,000 WBCs until proven otherwise?
SEPTIC
Joint with 75+% neutrophils (PMNs) is indicative of?
Septic joint
What type of joint presents with + culture?
Septic joint
