Exam 3 Material Flashcards
Chronic Fatigue Syndrome is aka:
Chronic Fatigue and Immune Dysfunction Syndrome
Chronic Fatigue Mainly Affects
Women
All ethnic and socioeconomic groups affected
Dx Criteria for CFS (Major)
Unexplained, persistent, or relapsing chronic fatigue of new and definite onset not d/t ongoing exertion
Not alleviated by rest*
S/S CFS (Chronic Fatigue Syndrome)
Incapacitating fatigue and exhaustion; may
wax and wane for mo to yrs or happen acutely leading to frustration
Lab Test for Chronic Fatigue Syndrome
No lab test can diagnosis–> used to exclude other diseases
Other (Minor) S/S of CFS (Chronic Fatigue Syndrome)
Impaired short term memory or concentration
Sore throat/Tender cervical/axillary lymph nodes
Muscle pain/Multi- joint pain
HA/ Unrefreshing sleep
Post-exertional malaise lasting over 24h
Role of WBC
Protection from invading organisms Recognition of self vs not-self Destruction of foreign invaders, debris, abnormal cells Production of antibodies Production of cytokines
Increase in total number of WBC’s d/t acute infection, tissue damage/death, leukemias
Elevation of any element of WBC differential
Neutrophilia
S/S of Neutorphillia
Related to cause of elevation –> tx cause
Exudate in form of pus
Dx Neutorphilia
CBC
Decrease in total WBC count
Leukopenia
Neutropenia
Reduced neutrophil count
occurs w/ other conditions or diseases→ not a disease in its self i.e. chemotherapeutic and immunosuppressive meds
ANC less than 1000 →
→ positive pressure room
Neutropenia – very compromised
ANC =
Absolute Neutrophil Count
WBC x %neutrophils
Other conditions/ diseases that causes Neutropenia include:
Hematologic malignancies
Autoimmune disorders – lupus/ ra
Nutritional deficiencies→ b12 or folic acid
Infections and Severe sepsis
Patients with neutropenia are at high risk of
opportunistic infections
Low grade fever = significant
Minor infections can lead rapidly to sepsis
Total WBC: less than 4,000
Neutropenia
ANC greater than 1500→
No increased risk of infection
ANC 1000-1500–>
→Slight increase in risk of infection
ANC 500-1000 →
Moderate increase in risk of infection
Neutropenia
ANC 100-500→
High risk of infection
ANC less than 100 →
Extremely high risk of infection
In patients with Neutropenia any ℅ pain/ infection–>
Serious
Common entry points for infection
Mucous membranes
Skin, throat, mouth
GU system
Pulmonary system
Neutropenia fever of 100.4
→Broad spectrum Antibiotic therapy for fever
Neutropenia Treatment
Tx Cause
Assist hematopoiesis in bone marrow
Isolation (Direct contact w/ hands=common source of transmission)
Monitor for infection, cultures
Neutropenia Treatment Teach
no fresh flowers, no fresh fruits or veggies
Neupogen, Neulasta
Granulocyte transfusion or stimulating factor
Pt w/ Neutropenia
V/S for pt w/ Neutropenia should be taken q….
q4h, call for T over 100.4
Myelodysplastic Syndrome (MDS)
producing plenty of cells, but they are all dysfunctional d/t Stem cell injury
Group of hematologic disorders –> changes in quantity and quality of bone marrow elements; May progress to leukemia (30%)
Myelodysplastic Syndrome (MDS)
AKA: Preleukemia
Myelodysplastic Syndrome (MDS)
Clinical Manifestations (MDS):
Anemia and fatigue, Infection risk, Bleeding risk
Diagnosing MDS
Bone Marrow biopsy – Dx, Classify, & Stage
Others CBC & H&P
Goal in MDS Tx
Improve hematopoiesis & Prevent leukemia
Nursing goal: Prevent infection, bleeding, & Treat symptoms of anemia
Tx Myelodysplastic Syndrome (MDS)
(aggressive); only 1/3 of pts are candidates
–Chemo
–Stem cell transplant (difficult for elderly)
TX should match severity of disease