Exam 3 - GU Flashcards
Complicated vs uncomplicated UTI
Complicated: associated with condition, men, pregnant women, children
Uncomplicated: healthy, immunocompetent, non pregnant women with no significant history of UTIs or structural abnormalities
Recurrent UTI definition
UTIs at least three times in one year or twice in six months
UTI - relapse vs reinfection
- Relapse: infection caused by bacterial persistence (infection by the previously treated pathogen) which was not completely eradicated by antibiotics
- Reinfection: recurrence of infection by introduction of a new bacterial strain or regrowth of same organism after complete eradication of the same organism after complete eradication with treatment
Diagnostic studies for UTI
- Urine dipstick (leukocytes, nitrites, blood)
- Definitive → urine culture (e. coli most common pathogen)
- Urinalysis
UTI treatment for non pregnant patients
- Nitrofurantoin (macrobid)
- TMP-SMZ (bactrim)
- Alternatives → keflex, fosfomycin, ciprofloxacin
UTI treatment for pregnant patients
Treat even if patient has asymptomatic bacteruria
- Keflex
- Amoxicillin
- Augmentin
Indications for referral for UTI
- Presence of macroscopic hematuria
- Suspected malignancy
- Recurrent UTIs or infections that do not respond to standard antimicrobial therapy
- Older adults with acute, severe symptoms
- History of chronic conditions
What is interstitial cystitis?
Chronic inflammatory condition of the bladder
Interstitial cystitis symptoms
- Bladder pain
- Urinary frequency or urgency
- Nocturia
- Suprapubic pain (relieved after voiding)
UTI vs interstitial cystitis
- Urinalysis with few leukocytes, no bacteria, occasional hematuria
- Negative urine culture
What is urethritis?
- Caused by infection characterized by discharge of mucoid or purulent material
- Burning with urination
- Often caused by neisseria gonorrhea (symptomatic)
- Chlamydia often asymptomatic
Urethritis symptoms
- Men: dysuria, frequency, urethral discharge, pruritus at distal end of penis
- Women: vaginal discharge or bleeding from concomitant cervicitis, lower abdominal pain
- Women typically asymptomatic
- Pain, itching, redness
Causes of urethritis
- Infectious - gonorrhea, chlamydia
- Non infectious - enteric organisms (MSM, anal sex)
Urethritis diagnostic studies
- Chlamydia and gonorrhea
NAAT testing
- Men: first catch urine
- Women: vaginal swabs (first line), first catch urine
Gonorrhea (urethritis) treatment
Persons with gonorrhea have a coexistent chlamydia infection
- Dual ceftriaxone + azithromycin or doxycycline
Non gonococcal urethritis treatment
Doxycycline 100 mg PO bid for 7 days
OR
Azithromycin
Can providers treat for gonorrhea and chlamydia at the same time?
Treat empirically for both infections if you do not have lab evidence of just one infectious cause
What is stress incontinence?
Loss of urine associated with activities that increase intra-abdominal pressure (sneezing, coughing) → overcomes sphincter and urethral pressure
What is urge incontinence?
Involuntary loss of urine usually preceded by a strong, unexpected urge to void (aka overactive bladder)
What is mixed incontinence?
Urge and stress incontinence together
What is overflow incontinence?
An involuntary loss of urine associated with incomplete emptying
Causes of urinary incontinence?
- Detrusor overactivity
- SCI below T11 to L1
- Poor bladder compliance
What is Resnick’s Diappers mnemonic?
- Identifies pathologic conditions external to the urinary tract that cause incontinence
- D - delirium or confusional state
- I - infection (urinary)
- A - atrophic urethritis, vaginitis
- P - pharmaceuticals
- P - psychological (severe depression)
- E - excess urinary output (CHF, hyperglycemia)
- R - restricted mobility
- S - stool impaction
Urinary incontinence diagnostic studies
- Urinalysis - exclude hematuria, pyuria, glycosuria, proteinuria
- Urine cytologic studies
- Urine culture
- BUN/creatinine,glucose, calcium
- Postvoid residual (PVR)
- Ultrasound or MRI to rule out anatomical or functional abnormalities
Urinary incontinence management
- Treat underlying condition → move commode to bedside
- Voiding diaries
- Behavioral therapies
- Medications: anticholinergic, alpha adrenergic agonist, antimuscarinic
- Surgery