Exam 3: Glucose lowering DM Medication

Question 1

what are glucose lowering mediaction

Answer 1

Class of medications categorized as Not Hypoglycemic (>70) and Potentially Hypoglycemic (<70)

Question 2

Not Hypoglycemic best for?

Answer 2

T2DM

Question 3

Not Hypoglycemic T2DM

Answer 3

Metformin/Glucophage

Glitazones

Alpha-glucosidase Inhibitors

SGL2-Inhibitor

Question 4

Potentially Hypoglycemic for?

Answer 4

T2 OR T1 & insulin

Question 5

Potentially Hypoglycemic T2 OR T1 & insulin

Answer 5

GLP-1 receptor agonist

Antioxidant

Antioxidant

Question 6

Metformin = Glucophage
who?

Answer 6

Type 2 DM: does produce insulin, prediabetes, PCOS

Question 7

Metformin = Glucophage
action

Answer 7

Decrease hepatic glucose production: liver produce glucose when fasting from liver glycogen (gluneogenesis). DM dont need more glucose

Increase /improve insulin sensitivity (decrease insulin resistance by muscle cells

Question 8

Metformin = Glucophage
concern

Answer 8

Concern: Associated with B12 deficiency

Question 9

Glitazones types

Answer 9

Actos Avandia

Question 10

Glitazones action

Answer 10

Increase insulin sensitivity

Promote Weight Gain

Question 11

Alpha-glucosidase inhibitors types

Answer 11

Acarbose & Precose (T2 DM)

Question 12

Alpha-glucosidase inhibitors action

Answer 12

Inhibit the enzyme that digest CHO (slow digestion/absorption of CHO)

Question 13

Alpha-glucosidase inhibitors complication

Answer 13

GI side effects (undigest/unabsorbed thus not raise BG -> fermentation @ colon ~ lactose intolerance)

Question 14

SGL2-inhibitors type

Answer 14

Jardiance (T2 DM)

Question 15

SGL2-inhibitors action

Answer 15

Inhibit glucose reabsorption in the kidneys (filter BG thru urine and reabsorb; some reabsorb too much, promote more urine BG excretion)

Question 16

GLP-1 receptor agonists type

Answer 16

Byetta, Victoza, Trulicity, Wegovy, Ozempic

Question 17

GLP-1 receptor agonists action

Answer 17

Injectable, Increase insulin, suppress glucagon

Delay gastric emptying & promote satiety

May promote weight loss

Question 18

Amylin Analogues type

Answer 18

Symlin Pramlintide

Question 19

Amylin Analogues action

Answer 19

Injected (mult/day) before meals to slow gastric emptying

Suppress Glucagon

Question 20

Insulin Secretagogues type

Answer 20

Sulfonylureas - Glipizide/Glucotrol, Glyburide

Glinides - Prandin, Starlix

Question 21

Insulin Secretagogues action

Answer 21

Stimulate insulin secretion (T2 starting to loose Beta cell function)

Question 22

Hyperglycemia ominuous octet

Answer 22

Decreased Peripheral glucose uptake

Renal glucose excretion

Increased Hepatic glucose output

Glucose influx

Increased Glucagon secretion

Decreased Insulin secretion

CNS Neurotransmitter dysfunction