Exam 3 - Bacterial Cell Wall Synthesis Inhibitors

Question 0

There is a lack of cross reactivity w/ B-lactams except…

Answer 0

Ceftazidime

- has a side chain identical to that of Aztreonam

Question 1

Bind to penicillin-binding protein (PBP) inhibiting cell wall synthesis

Answer 1

B-lactam

Question 2

Penicillins lack activity against

Answer 2

Atypical bacteria

Nearly all lack activity against MRSA (EXCEPT CEFTAROLINE)

Question 3

PCN/B-lactamase enzyme inhibitor combinations

Answer 3

Clavulanate + Amoxacillin
Tazobactam + Piperacillin
Sulbactam + Ampicillin

Question 4

Drug of choice for syphillis; can also be used for meningococci (meningitis) since it penetrates the CNS when meninges are inflamed

Answer 4

Penicillin G

Question 5

Prebenicid prolongs the half-life of this drugs

Answer 5

Penicillin G

Question 6

Natural penicillins have poor activity against…?

Answer 6

Gram negative

Question 7

Indicated for Group A streptococcus (Streptococcus pyogenes); narrow spectrum

Answer 7

Penicillin VK