Exam 3 Flashcards
functions of blood
transportation
regulation
defense
blood transportation
oxygen and carbon dioxide
nutrients, hormones, waste products
blood regulation
absorbs heat and distributes throughout body
regulates body pH and fluid levels
blood defense
protect from infection
transport infection fighting antibodies
forms blood clots
blood composition
55% plasma
Buffy coat: leukocytes and platelets 1%
erythrocytes: 44 % (red)
plasma
92% water
7% protein
other solutes
proteins in plasma
albumins
globulins
fibrinogen
regulatory proteins
other solutes in plasma
electrolytes
nutrients
respiratory gases
waste products
erythrocytes (RBC’s) structure
small, biconcave disc
- allow gas to be loaded/unloaded
erythrocyte characteristics
filled with hemoglobin (transport o2 + CO2)
no nucleus or organelles
single file as pass through vessels
erythrocyte life cycle
form in red bone marrow
circulate in blood stream (120 days)
aged phagocytized in liver, spleen, bone marrow
old broken to make new
heme converted to bilirubin and secreted in bile by liver
polycythemia
too many erythrocytes in the blood
increase viscosity of blood, strain on heart
anemia
low levels of erythrocytes or hemoglobin
low blood O2 levels
leukocyte (WBC) structure
larger than erythrocytes
leukocyte characteristics
nucleus and organelles
initiate immune response and defend against pathogens
diapedesis and chemotaxis
diapedesis
WBC leave blood stream and enter tissue
chemotaxis
WBC attracted to site of infection by damaged cells, dead cells, or invading pathogens
types of leukocytes
granulocyte and agranulocyte
granulocytes
neutrophil
eosinophil
basophil
neutrophil
phagocytizes pathogens
granulocyte
eosinophil
destroy parasite
allergies
granulocyte
basophil
promote inflammation by releasing histamine and heparin
granulocyte
agranulocytes
monocyte
lymphocyte
monocyte
exit bloodstream and become macrophage
phagocytize pathogen and debris
agranulocyte
lymphocyte
reside in lymphatic tissue
coordinate immune response
t call, B cell, natural killer
agranulocyte
lymphocyte
reside in lymphatic tissue
coordinate immune response
t call, B cell, natural killer
agranulocyte
leukocytosis
High WBC count
infection, inflammation, extreme stress
leukopenia
low WBC count
viral or bacterial infection
leukemia
cancer in leukocyte forming cells in bone marrow
proliferation of abnormal leukocytes
cancer cells take over bone marrow - slow erythrocytes and platelets - anemia and bleeding
platelets (thrombocytes)
cell fragments of megakaryocytes
live 8-10 days
assist in blood clotting
blood clots
fibrin (form fibrinogen)
platelets
trapped erythrocytes
thrombocytosis
high platelet count
results from disease of blood or bone marrow, cancer, removal of spleen, or an infection
thrombocytopenia
low platelet count
damage to bone marrow, chemotherapy, leukemia, overactive spleen
what determines blood type
surface antigens
how are antibodies formed
against antigens it doesn’t have
group A antibodies and antigens
anti B - antibodies
A antigen
group b antibodies and antigens
anti A - antibodies
b antigen
group AB antibodies and antigens
no antibodies
a and B antigens
group o antibodies and antigens
anti a and anti b antibodies
no antigens
hematopoiesis (hemopoiesis)
production of blood’s formed element
- erythropoiesis, thrombopoiesis, leukopoiesis
red bone marrow
erythropoietin made by kidney controls erythrocyte production
erythropoiesis
formation of red blood cells
thrombopoiesis
formation of platelets
leukopoiesis
formation of white blood cells
how often heart beats
75/minute
108,0000/day
average cardiac output
5.25 L/min
heart is a dual pump for what?
pulmonary and systemic circuits
heart orientation
within mediastinum
lies on diaphragm, posterior to sternum
base
posterior and superior surface of heart
apex
anterior and inferior, points to left hip
3 layers of pericardium
fibrous pericardium
serous (Parietal and visceral)
pericardial cavity
contains serous fluid
pericardium functions
prevent undesired movement
prevent overfilling of the heart
reduces friction
epicardium
visceral layer of serous pericardium
simple squamous epithelium
myocardium
cardiac muscle
bulk of the heart wall
endocardium
lines chambers and covers valves
simple squamous epithelium
“endothelium”
pulmonary circuit
carries blood too and from lungs
right ventricle is the pump
systematic circuit
transport blood too and from body tissues
left ventricle is the pump
oxygen poor blood
before lungs
oxygen rich blood
after lungs
right atrium
receiving chamber for oxygen poor blood from systemic circuit
right ventricle
pump of the pulmonary circuit
eject oxygen poor blood into pulmonary trunk
fossa ovalis
formane ovale during fetal circulation
papillary muscles
anchor chord tendineae
chordae tendineae
prevent valves from everting
left atrium
posterior surface of heart
receive oxygen rich blood from lungs through pulmonary veins
left ventricle
form apex and inferior surface of the heart
pump of systemic circuit- oxygen rich blood to aorta
most muscular of the chambers
heart valve structure
composed of dense connective tissue
two or three cusps
heart valve function
permit passage of blood in one direction
prevent back flow of blood
fibrous skeleton of the heart
dense connective tissue between atria and ventricles
fibrous skeleton functions
separates atria and ventricles
anchors heart valves
framework for cardiac muscle attachment
cardiac muscle tissue structure
short, branched
striated
1-2 nuclei
cardiac muscle tissue function
cells joined by intercalated discs
more mitochondria and ATP Tham skeletal muscle
gap junction and desmosomes
gap junctions
increase flow of electrical current
desmosomes
prevent cardiac muscle from pulling apart
Myocardial contractile cell
99% atria and ventricles
Myocardial conducting cells
conduction system of the heart
conduction system
specialized muscle cells that carry electrical impulses throughout the heart musculature
sequence of heartbeat
a. Cardiac rhythm established by sinoatrial node
b. Spreads through internodal pathways
c. Interatrial band connects directly the two atriums
d. Electrical event is trigger for muscle contraction
Atrioventricular bundle
goes through interventricular septum them splits in left and right bundle branches
Purkinje fibers
additional fibers that spread impulse cells in ventricle
Purkinje fibers
additional fibers that spread impulse cells in ventricle
cardiac plexus
parasympathetic NS
sympathetic NS
parasympathetic NS
emerges from medulla
vagus nerve (CN X)
decrease heart rate
sympathetic NS
emerges from thoracic spinal cord
synapses in sympathetic chain ganglia
increases heart rate and force of contraction
coronary circulation
brings nutrients and oxygen to the heart wall
inadequate circulation causes heart attack
heart failure
progressive weakening of heart
can’t pump blood to meet bodies needs
weak ventricles fail to empty - overfill - back into veins
edema (congestion) in tissue outside pulmonary or systemic circuits
arteries
transport blood away from the heart
carry oxygen rich blood in systemic circuit
carry oxygen poor blood in pulmonary circuit and umbilical arteries
capillaries
smallest blood vessels
location of gas and nutrient exchange between blood and tissues
veins
transport blood towards the heart
carry oxygen poor blood in systemic circuit
carry oxygen rich blood in the pulmonary circuit and umbilical vein
tunica intima
simple squamous epithelium called endothelium
tunica media
circularly arranged smooth muscle fibers
location of vasodilation and vasoconstriction
tunica externa
collagen and elastic fibers
contains vasa vasorum
vessel tunics order
endothelium
basement membrane
internal elastic membrane
smooth muscle
external elastic membrane
vasa vasorum
tunica extenra
vessels in arteries
thick walls, small lumens
thickest layer is tunica media
capillaries
very small lumen (one RBC at a time)
only tunica intimate
allow rapid gas exchange
veins
thin wall, large lumens
thickest layer is tunica external
valves
elastic arteries
largest arteries
conducting arteries
high elastin content
aorta and major branches
conducting arteries
between heart and muscular arteries
high elastin content
stretch and recoil to dampen blood pressure changes resulting from contractions of heart
aorta and major branches
brachiocephalic
common carotid
subclavian
common iliac arteries
muscular arteries
distributing arteries - to body organs
thick tunica media
diameter of lumen changes to regulate blood flow and organs
named arteries in lab
muscular arteries
distributing arteries - to body organs
thick tunica media
diameter of lumen changes to regulate blood flow and organs
named arteries in lab
paired arteries you don’t know
inferior phrenic artery (above trunk)
suprarenal artery (superior kidney)
unpaired arteries you don’t know
abdominal aorta (abs)
median sacral artery (middle split)
arteriole
diameter regulated by local tissue factors
sympathetic nervous system
capillaries
smallest vessels
tunica intimate only
gas, nutrient, waste exchange
venules
smallest veins
primary location of diapedesis
continuous capillary
most common
muscle, skin, thymus, lungs
tight junctions, water transportation