Exam 2 (Intro and Major minerals [Ca, P, Mg, Na, Cl, K, S] ) Flashcards
Minerals represent ___% of our body weight
4-5%
Breakdown of minerals in the body is: 50% ______, 25% _______, and 25% as the remaining ___ minerals
50% Calcium
25% Phosphorus
25% 14 other minerals
What % of Calcium and Phosphorus are stored in bones?
99% calcium
70% phosphorus
Things that make a mineral a mineral
- Must be mined
- Can’t be synthesized in labs
- Mostly extracted as salt forms (Calcium carbonate)
T/F All minerals are absorbed in their ionic state
FALSE.
Heme Iron is the only mineral that is not absorbed in its ionic state
Absorption of minerals is often influenced by many _________ in the diet
Organ factors (Ex: Vitamin C enhances absorption from plants)
Most minerals with a positive charge are called this
Metals
Most minerals with a negative charge are called this
Nonmetals
Only mineral with a + charge that is called a nonmetal
Hydrogen (H+)
Names for proteins and enzymes that contains metal
Metalloproteins
Metalloenzymes
What makes a mineral a major mineral?
Requires >100 mg/day
Major minerals
Ca, Cl, Mg, P, K, Na, S
T/F About 2% of our total body weight is Ca
True
T/F Calcium is found naturally in nature and supplements, so it does not need to be digested to be absorbed
FALSE.
Ca is found as salts in nature and supplements. The Ca must be released from the salt to be absorbed
Most common form of Ca in supplements and fortified foods.
Calcium carbonate (CaCO3)
What does calcium carbonate require in order to be released?
At least 1 hour in an acidic environment (take with a meal)
Other calcium salts. Do these require an acidic environment to release the Ca?
Calcium citrate
Calcium lactate
They do NOT require an acidic environment to release the Ca
Protein that enables Ca to be absorbed by active transport. What stimulates this protein? Is this protein saturable?
Calcium binding transport protein (Calbindin 9k)
Stimulated by Vitamin D
Yes
What enables the passive diffusion of Ca absorption to start?
Passive diffusion starts when the Calbindin 9k (from active transport) becomes saturated during times when lots of Ca has been consumed
T/F The passive diffusion of calcium requires vitamin D
FALSE.
Only active transport requires Vitamin D, passive transport does not
Amount of Ca we can only absorb at a given time
500 mg
Amount of Ca we can only absorb at a given time
500 mg
The body has low blood calcium. Explain the steps (and hormones) used to increase serum calcium levels.
1) Low Ca causes PTH to be released from the parathyroid glands
2) PTH induces hydroxylase in the kidneys to activate calcitriol (active Vitamin D)
3) Calcitriol stimulates synthesis of Ca binding proteins
4) Ca binding proteins (Calbindin) increase Ca absorption in the small intestine and decrease Ca excretion in the kidneys.
5) Serum Ca levels normalize
Calcium binding proteins and which organ each acts on
Calbindin 9k = Small intestine (increases absorption)
Calbindin 28k = Kidneys (decreases excretion)
Enhances Ca absorption
Vitamin D
Sugars (lactose)
Protein
Inhibits Ca absorption
Fiber Phytate Oxalate Divalent minerals (Zn, Mg, Cu) Fatty acids
Increases Ca excretion
Na
Protein
Caffeine
Decreases Ca excretion
Estrogen
K
P
Ca RDA in adults 19-50 and adults >51
Adults 19-50 = 1000 mg
Adults >51 = 1200 mg
Ca sources
Dairy Fish (esp. canned) Spinach Tofu Fortified grains
Ca functions
1) Bone mineralization (found with P, F, Mg, K, Sr, Na in osteoblasts)
2) Cell signaling (muscle contraction, nerve conduction, blood clotting, enzyme regulation, membrane permeability)
Other nutrients (besides Ca) in bone calcification
- Vitamin A (osteocyte mainenance)
- Vitamin D (Ca absorption)
- Vitamin K (protein formation)
- Vitamin C and B6 (collagen synthesis)
Ca deficiency
Hypocalcemia
Symptoms of hypocalcemia
Tetany
Paresthesia
(nerves are hyperexcitable from lowering the threshold to fire action potentials)