EXAM #2: HYPERTENSION Flashcards

1
Q

What is the life-time risk for a normotensive person at age 55 for developing HTN?

A

90%

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2
Q

How much does an increase in 20 mmHg (systolic) or 10 mmHg diastolic increase the risk for CVD?

A

Doubles it for EACH increase

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3
Q

How much does HTN increase the risk for CVD in women?

A

Triples the risk

In men, closer to doubles the risk

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4
Q

What is the general trend between HTN and mortality?

A

Increased HTN= increased mortality

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5
Q

Does JNC VIII define HTN?

A

No

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6
Q

What does JNC VIII do?

A

Recommends BP levels to begin drug therapy

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7
Q

What are the determinants from JNC VIII that play into the decision of when to start drug therapy for HTN?

A

1) Age
2) Coexisting disease i.e.
- DM
- Chronic renal disease
3) Race

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8
Q

IF the BP cuff is too loose, what will happen to your reading?

A

Overestimation of the BP

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9
Q

IF the BP cuff is too-narrow, what will happen to the BP reading?

A

Overestimate–it takes more pressure than usual to reach pressures that will occlude the artery

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10
Q

What are the five Korotkoff sounds?

A

1) Tapping sounds when the brachial artery opens
2) Soft murmurs
3) Louder murmurs
4) Muffling
5) Disappearance

Note that you measure 1st and 5th sounds in adults

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11
Q

What is borderline HTN?

A

BP occasionally exceeds normal

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12
Q

What is primary HTN?

A

Elevated BP without a known cause

*Note that 90% of HTN is PRIMARY

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13
Q

What is secondary HTN?

A

Elevated BP WITH a known cause

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14
Q

What is a HTN emergency?

A
  • Life-threatening circumstance
  • Focal/ generalized sx. of target-organ damage

*Requires rapid reduction of BP and typically involves a dBP greater than 120 mmHg

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15
Q

What are signs of target-organ damage?

A

1) Retinal damage

2) CNS sx.

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16
Q

What is malignant HTN?

A

HTN retinopathy grade III and IV WITH severe BP elevation

*Evidence of ongoing target organ damage (to the brain b/c the retina is part of the brain)

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17
Q

What is HTN encephalopathy?

A

Signs/sx. of cerebral edema caused by severe rise in BP

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18
Q

Outline the grading system for Hypertensive Retinopathy.

A

1) Arteriolar narrowing (take on a shiny copper appearance)
2) AV nicking
3) Hemorrhages and exudates
4) Papilledema

19
Q

What stages of Hypertensive Retinopathy are indicative of target-organ damage?

A

Grades 3 and 4

20
Q

How can you identify papilledema on fundoscopy if you’re unsure?

A

BVs look like they’re coming out of the side of the optic disc b/c it is pushed upward

21
Q

What are the possible CNS consequences of HTN?

A

1) Decreasing cognitive function
2) TIA
3) CVA

22
Q

What is the leading cause of end-stage renal disease?

A

Systemic arterial hypertension (SAH)

23
Q

What are the early effects of SAH on the heart?

A
  • Increased LV mass

- Consequent loss of LV compliance/ diastolic function (filling)

24
Q

What are the chronic effects of SAH on the heart?

A

LVH with LV dilation

*Leads to death

25
Q

What are the effects of SAH on the vascular system?

A

SAH is a major risk factor for:

1) ASCVD
2) MI
3) HF
4) Sudden cardiac death

26
Q

What are the major goals in evaluating systemic HTN?

A

1) Assess CV risk factors
2) Look for identifiable reasons for SAH e.g.
- Renal parenchymal disease
3) Determine target-organ damage

27
Q

List some of the common conditions that cause secondary HTN.

A
  • Chronic renal parenchymal disease
  • Primary aldosteronism
  • Renovascular disease
  • Cushing’s Syndrome
  • Pheochromocytoma
  • Coarctation of the aorta
  • Thyroid or PTH disease
  • Sleep apnea
  • Drug-induced or related causes
28
Q

What is the most common presentation of SAH?

A

Asymptomatic

29
Q

What is the most common form of target organ damage in SAH?

A

IHD

30
Q

What are the five diseases that require additional attention in SAH?

A

1) IHD
2) HF
3) DM
4) CKD
5) Cerebrovascular disease

31
Q

What part of the physical exam should never be omitted on a patient with HTN?

A

Fundoscopic exam

*B/c this is the only location in the body that you can look directly at the BVs

32
Q

What are the min. labs that should be ordered for patient with a new diagnosis of SAH?

A

1) Urine dipstick
2) Fasting glucose
3) Hematocrit
4) Serum creatinine
5) Serum Ca++ and K+
6) Lipid panel

*AND an ECG

33
Q

What is unprovoked hypokalemia a sign of?

A

Secondary HTN

34
Q

What is the utility of Echocardiogram in the diagnosis of SAH?

A

Determination of LV function

*Note that severe/ refractory HTN with NO LVH= v. recent onset or white coat syndrome

35
Q

What is the JNC VIII recommendation for a systolic BP in drug therapy?

A

sBP less than 140 mmHg

36
Q

What did the recent SPRINT trial show about drug therapy for HTN?

A

Intensive therapy i.e. a sBP less than 120 mmHg had fewer primary outcomes

37
Q

Reducing blood pressure reduces what complication the most?

A

CVA

38
Q

What are the non-drug therapies recommended for SAH?

A

1) DASH diet
2) Na+ restriction
3) Regular exercise
4) Maintain healthy weight
5) NO smoking

39
Q

Why should antacids be avoided in patients with SAH?

A

Some antacids contain high Na+

40
Q

According to the JNC VIII, what is the drug of choice for treating HTN?

A

Thiazide diuretics

41
Q

What is the JNC VIII recommendation on when to start drug therapy?

A
sBP= 150 mmHg 
dBP= 90 mmHg
42
Q

What is the recommended initial anti-HTN therapy in the black population?

A

Thiazide diuretic or Ca++ blocker

43
Q

What is the first-line therapy for HTN in patients with CKD?

A

ACEI or ARB

44
Q

What is the most common adverse effect of ACEIs?

A

Chronic dry cough