EXAM #1: REVIEW OF ECG Flashcards
Where is the Cl- concentration high?
Extracellular
Is the cardiac cell negatively charged or positively charged intracellularly?
Negative
What are the five phases of the cardiac action potential?
0= Rapid upstroke/ depolarization 1= Early repolarization 2= Plateau 3= Rapid repolarization 4= Resting membrane potential
Describe the ion flux in phase 0 of the cardiac action potential.
- Rapid influx of Na+
- FAST Na+ channels
“Rapid depolarization”
Describe the ion flux in phase 1 of the cardiac action potential.
- Na+ channels close
- Voltage-gated K+ channels OPEN and K+ moves OUT
“Early repoarlization”
Describe the ion flux in phase 2 of the cardiac action potential.
- Slow Ca++ channels open
- Opposing movement of Ca++ IN and K+ out= PLATEAU
Why is the plateau phase of the action potential important?
This phase corresponds to systole; the pause allows contraction to occur
Describe the ion flux in phase 3 of the cardiac action potential.
- Ca++ channels close
- K+ channels are still OPEN
- K+ OUT
“Rapid repolarization”
Describe the ion flux in phase 4 of the cardiac action potential.
- Na+/K+ ATPase
- Only K+ channels are open and a SMALL amount of K+ fluxes
“Resting membrane potential”
How many phases are there in the nodal action potential? What are they?
Three phases: 0, 3, and 4
What phases are missing from the nodal action potential?
1 and 2
How does the resting membrane of the nodal action potential differ from the cardiac myocyte action potential?
Cardiac myocyte= -90mV
Nodal= -60 mV
Describe the ion flux in phase 0 of the nodal action potential.
- Upon reaching threshold, Slow Ca++ channels open
- Ca++ INFLUX
Describe the ion flux in phase 3 of the nodal action potential.
- After depolarization, K+ channels open
- K+ EFFLUX
Describe the ion flux in phase 4 of the nodal action potential.
- Funny channels open (HCN)
- K+ efflux progressively declines
- Ca++ influx occurs, leading to slow depolarization
Outline the normal sequence of depolarization in the heart.
1) SA node
2) Atrial syncitium/ internodal tracts
3) AV node
4) Bundle of His
5) Purkinjie fibers
6) Ventricles
What sequence of depolarization occurs in the ventricles?
1) Interventricular septum
2) Apex of the heart
3) Ventricular free walls
What are the two branches of the left bundle branch?
Left aterosuperior fasicle
Left posteroinferior fasicle