Exam 2; Aggressive Periodontitis Flashcards
What are the overall characteristics of AP
non-contributary medical history
rapid attachment and bone loss
familial aggregation
lack of consistency between bacterial deposits and severity of breakdown
This is important when recognizing AP
early detection
Which group of people is more prone to AP
children/adolescents
What are four specific indicators of AP
marginal bone loss
presence of clinical attachment loss
increased probing depths
plaque
There is an absence of this when diagnosing the localized form of AP
systemic disease that may severely compromise host response or lead to premature exfoliation of teeth
What is the distribution of localized AP
not more than 2 teeth are affected in addition to the first molars and incisors
What is the clinical outcome of LAP
severe destruction of periodontal tissues in a short time
What are two possible reasons for destructive process
aggressive causative agents
high level of susceptibility
What is one of the main bacterial etiologies in LAP
AA
This is one of the main pathologies of AA
leukotoxin
These levels are pretty high in regards to AA
Ab levels
IgG2 levels
What are some genetic factors of LAP
familial aggregation
most likely substantial genetic polymorphism
proposed model = autosomal dominant
This has been shown to increase the likelihood of GAP but not so much LAP
smoking
L/GAP is what type of factorial disease
multifactorial disease
L/GAP can result from an imbalance in what
host genes and environment
This is necessary to cause L/GAP
exposure to a pathogen and the host’s inability to deal with it to avoid damage
This of L/GAP is determined by modifying environmental (smoking) or genetic factors
phenotype
What is the pathogenesis of AP
normal to LAP to GAP
What two things can cause normal to go to LAP
exposure to bacterial infection; AA
genetic predisposition
What three things can cause LAP to go to GAP
smoking
other bacteria
genetic modifying factors
What are some questions to answer when diagnosing L/GAP
is there periodontitis match of plaque/calculus/local factors with periodontal destruction systemic component microbiological diagnosis other family members host defenses
What are four treatment principles of L/GAP
referral to a periodontist
elimination or suppression of microflora
address environmental factors
provide environment conducive to long term maintenance
