Exam 2 Flashcards
what percent of the total body weight is composed of muscles
40-50%
3 functions of skeletal muscle
- force production for locomotion and breathing
- force production for postural support
- heat production during cold stress
order of muscle covering
- Epimysium
- surrounds entire muscle - perimysium
- surrounds fascicles - endomysium
- surrounds individual muscle fibers - basement membrane
- just below endomysium - sarcolemma
- muscle cell membrane
what are the 4 parts of the microstructure of muscle fibers
- myofibrils
- sarcomere
- sarcoplasmic reticulum
- transverse tubules
what is in the myofibrils
Contractile proteins
- actin
- myosin
what makes up a sarcomere
- z line
- m line
- H zone
- A band
5 I band
where is the storage site for calcium
sarcoplasmic reticulum
where is the terminal cisternae
in the sarcoplasmic reticulum
where does the transverse tubules extend to and from
extend from the sarcolemma to the sarcoplasmic reticulum
what is the neuromuscular junction
junction between motor neuron and muscle fiber
what is a motor unit
motor neuron and all fibers it innervates
what is the motor end plate
pocket formed around motor neuron by sarcolemma
what is the neuromuscular cleft
short gap between neuron and muscle fiber
where is acetylcholine released from and what does it cause
- released from the motor neuron
- causes an end plate potential (EPP)
- causes depolarization of the muscle fiber
what is the sliding filament model
muscle shortening occurs due to the movement of the actin filament over the myosin filament
-this causes the formation of cross bridges between actin and myosin filaments POWER STROKE
Energy is needed for Muscle Contraction, how does the muscle utilize the ATP
- myosin ATPase breaks down ATP as the fiber contracts
- ATP—>ADP +Pi
what are the sources of ATP used for muscle contraction
- PC
- glycolysis
- oxidative phoshorylation
what nutrient enforces muscle contraction
calcium
what are fast twitch fibers
anaerobic muscle
used for strength and power
high sarcoplasmic reticulum development
what are slow twitch fibers
endurance muscle, aerobic
everyday muscle
what are free radicals
a compound that loses electrons and is unstable which in turn disrupts cell activity
what is excitation-contraction coupling
Depolarization of the motor end plates (excitation) is coupled to muscular contraction
how does excitation contraction coupling work
- the action potential travels down transverse tubules and causes the release of Calcium ions from the sarcoplasmic reticulum
- Calcium binds to troponin and causes position change in tropomyosin which eposes active sites on actin
- strong binding state formed between actin and myosin
Contraction
what are the 2 main parts of excitation
- action potential in motor neuron causes release of acetylcholine into synaptic cleft
- acetylcholine binds to receptors on motor end plate, leads to depolarization that is conducted down transverse tubules, which causes release of calcium from SR
what are the 5 steps in contraction
- at rest myosin cross bridges are in a weak binding state
- calcium binds to troponin causing a shift in the tropomyosin to uncover active sites, and cross bridge forms strong binding state
- Pi released from myosin, cross-bridge movement occurs
- ADP released from myosin
- ATP attaches to myosin, breaking the cross bridge and forming weak binding state.. ATP then binds to myosin, broken down to ADP-Pi which energizes myosin.
what is muscle fatigue
decline in muscle power output
- decrease in force generation
- decrease in shortening velocity
how long does muscle fatigue take in high intensity exercise
roughly 60 seconds
what accumulates during high intensity exercise
lactate ADP Pi free radicals -all of these diminishes cross bridges bound to actin
how long do muscles take to fatigue during long duration exercise
2-4 hours
what are 3 muscle factors that need to be taken into consideration during long duration exercise
accumulation of free radicals
electrolyte imbalance
glycogen depletion
what are muscle cramps
spasmodic involuntary muscle contractions
what is the electrolyte depletion and dehydration theory
water and sodium loss via sweating causes spontaneous muscle contractions
what is the altered neuromuscular control theory
muscle fatigue causes abnormal activity in muscle spindle and golgi tendon organ
-leads to increased firing of motor neurons
characteristics of the slow twitch fibers
Slow Twitch: 1. small motorneuron 2. low recruitment threshold 3. slow conduction velocity 4. small muscle fiber 5.less SR development 6 high mitochondrial density 7. high capillary density 8. high myoglobin content 9. low PC stores 10. low glycogen stores 11. high triglyceride stores
characteristics of fast twitch fibers
Fast Twitch
- Large motorneuron size
- high recruitment threshold
- fast conduction velocity
- large muscle fibers
- more SR development
- high mitochondrial density
- medium capillary density
- medium myoglobin content.
- high PC stores
- high glycogen stores
- medium triglyceride stores
what percentage of slow and fast twitch fibers do non athletes have
roughly 50/50 split
predominant fiber type in endurance and power athletes
- power: fast twitch
2. endurance: slow twitch
2 types of muscle action
- isometric
2. isotonic
what is isometric muscle action
- muscle exerts force without changing length
- pulling against immovable object
- postural muscles
what is isotonic muscle action
two types
1. concentric: muscle shortens during force production
2 eccentric
-muscle produces force but length increases.
*** this type is associated with muscle soreness
define muscle twitch
contraction as the result of a single stimulus
3 parts of a muscle twitch
- latent period (5ms)
- contraction (tension is developed 40ms)
- relaxation (50ms)
3 types of frequency stimulation
- simple twitch
- summation
- tetanus (max tension)
what is sarcopenia
it is the gradual loss of muscle due to aging
what percent of muscle mass is lost between the age of 25-50 years
10%
what percent of muscle mass is lost between 50-80
40%
what type of training can delay age related muscle loss
resistance training
what is the force velocity relationship
at any absolute force the speed of movement is greater in muscle with higher percent of fast twitch fibers
**the max velocity of shortening is greatest at the lowest force
4 processes by which O2 and CO2 are transported and expelled
- Pulmonary Ventilation (external)
- Pulmonary Diffusion (external respiration)
- Transport of gases via blood
- capillary diffusion (internal respiration
what is pulmonary ventilation
process of moving air into and out of the lungs
- transport zone
- exchange zone
what is the pathway of pulmonary ventilation
- nose/mouth
- nasal conchae
- pharynx
- larnyx
- trachea
- bronchial tree
- alveoli
Pulmonary Ventilation- Inspiration
- active process
- involved muscles
- diaphragm flattens
- external intercostals move rib cage and sternum up and out - expands thoracic cavity in three dimensions
- expands volume inside thoracic cavity
- expands volume inside lungs
- lung volume increases while intrapulmonary pressure decreases
- air passively rushes in due to pressure difference
- air passively rushes in due to pressure difference
- forced breathing uses additional muscles
what additional muscles are used in forced inspiration
scalenes
sternocleidomastoid
pectorals
Pulmonary Ventilation- Expiration
1 usually a passive process
- inspiratory muscles relax
- lung volume decreases while intrapulmonary pressure increases
- air forced out of lungs
2. active process (forced breathing during exercise)
what muscles are involved in the active process of expiration
- internal intercostals pull ribs down
- latissimus dorsi
- quadratus lumborum
- abdominal muscles force diaphragm back up
what is the normal atmospheric pressure
760 mmHg
what is the intrapleural pressure
756mmHg
how are pulmonary volumes measured
spirometry
- lung volume capacities, flow rates
- tidal volume
- vital capacity
- residual volume
- total lung capacity
what is the total lung capacity the sum of
Vital capacity and Residual Volume
define vital capacity
greatest amount of air that can be expired after a maximal inspiration
define tidal volume
amount of air entering and leaving the lungs with each normal breath
define functional residual capacity
volume of air remaining in the lungs after normal expiration
define residual volume
amount of air remaining in the lungs after MAXIMAL expiration
define pulmonary diffusion
gas exchange between alveoli and capillaries
what is the inspired air path for pulmonary diffusion
bronchial tree and it arrives at alveoli
what is the blood path for pulmonary diffusion
right ventricle to the pulmonary trunk to the pulmonary arteries to the pulmonary capillaries
(capillaries surround alveoli)
2 major functions of pulmonary diffusion
- replenishes blood oxygen supply
2. removes carbon dioxide
at rest how much blood do the lungs receive every minute
4-6L
what 2 things are equal at rest with regards to pulmonary diffusion
Lung blood flow=systemic blood flow
what is the respiratory membrane within pulmonary diffusion
(alveolar-capillary membrane) the surface across which gases are exchanged
(300 million alveoli)