Exam 2

Question 1

Neurofibrillary Tangles

Answer 1

-form inside nerve cells
- over-production of tau proteins
- fold abnormally

Question 2

Beta-Amyloid Neuritic Plaques

Answer 2

• build up between neurons
• Beta-amyloid protein builds up in
  brain
• becomes insoluble

Question 3

Pathophysiological signs of Alzheimers

Answer 3

Neurofibrillary Tangles and Beta-Amyloid Neuritic Plaques

Question 4

Major neurocognitive impairment

Answer 4

The DSM V term for Dementia. Evidence of significant cognitive decline that must be severe enough to disrupt independence in ADLs

Question 5

Criteria for major neurocognitive impairment

Answer 5

Evidence of significant cognitive decline in one or more cognitive domains:
– Learning and memory
– Language
– Executive function
– Complex attention
– Perceptual-motor
– Social cognition

Cognitive deficits affect daily independence and are not caused by delirium or another mental disorder like depression or schizophrenia.

Question 6

Mild neurocognitive impairment

Answer 6

• Preclinical condition (early stage) that suggest one is at risk for developing dementia.
• Evidence of slight cognitive decline, does not interfere with independent completion of ADLs

Question 7

Criteria for mild neurocognitive impairment

Answer 7

• Self- Reported memory issues, confirmed by a family member or caregiver.
• Memory impairment shown on assesments, beyond normal aging.
• No problems with reasoning, general thinking skills, or daily activities.

Question 8

Dementia

Answer 8

degenerative, multiple cognitive domains slowly decline, making it hard to communicate, interact with others, work, and do daily activities.

Question 9

Cognitive domains affected by dementia:

Answer 9

• memory
• executive function
• attention
• language
• visuospatial function
• instrumental/activities of daily living (ADLS)

Question 10

Amnestic MCI

Answer 10

MCI that affects memory first

Question 11

Nonamnestic MCI

Answer 11

MCI in which non-memory cognitive functions are affected first