Exam 2 Flashcards
i. Contains no blood vessels or nerves
ii. Surrounded by the perichondrium (dense irregular CT) that resists outward expansion
Skeletal Cartilage
a. Provides support, flexibility, and resilience
b. Most abundant skeletal cartilage
c. Present in these cartilages
i. Articular – covers the ends of long bones
1. Form a joint
ii. Costal – connects the ribs to the sternum
iii. Respiratory – makes up larynx; reinforces air passages
iv. Nasal - supports the nose
Skeletal Cartilage
Hyaline
a. Similar to hyaline cartilage
i. BUT contains more elastic fibers
ii. Found in
1. External ear
2. Epiglottis
Skeletal Cartilage
Elastic
a. Highly compressed
b. Great tensile strength
c. Contains collagen fibers – Really thick, can see them
d. Found in
i. Menisci of the knee
ii. Pubic symphysis
iii. Glenoid (shoulder)
iv. Acetabular labrum (hip)
v. Intervertebral discs
e. Located in places that take a LOT of compression
Skeletal Cartilage
Fibrocartilage
Appositional Growth
Insterstitial Growth
Calcification/Ossification
Types of growth in cartilage
i. Cells in the perichondrium secrete matrix against the external face of existing cartilage
ii. Grows to the side and outward
Appositional Growth
i. Lacunae bound chondrocytes inside the cartilage divide and secrete new matrix,
ii. expanding the cartilage from within.
Interstitial Growth
i. During normal bone growth
1. Increases length and width of the bone
ii. During old age
1. Decreases flexibility at the joints
Calcification/Ossification
growth of cartilage
Axial Skeleton
Appendicular Skeleton
Major regions of skeleton
i. Bones of skull
ii. Vertebral column
iii. Rib cage
Axial region of skeleton
i. Bones of upper limbs
ii. Lower limbs
iii. Shoulder
iv. Hip
Appendicular region of skeleton
a. Support – form the framework that supports the body and cradles soft organs
b. Protection – provide a protective case for the brain, spinal cord, and vital organs
c. Movement – provide levers for muscles
d. Mineral storage – reservoir for minerals, especially calcium and phosphorus
e. Blood cell formation – hematopoiesis occurs within the red marrow cavities of bones
5 important functions of bones
Long
Short
Flat
Irregular
Classifications of bones based on shape
Bone shape - longer than they are wide
Ex: Humerus
Long bones
Bone shape - Cube shaped bones of the wrist and ankle
Short bone shape
Bone shape - thin, flattened, and a bit curved
i. Eg. Sternum
ii. Most skull bones
Flat bone
Bone shape - bones with complicated shapes
i. Ex: vertebrae
ii. Pelvis bone
Irregular bone shape
bone-forming cells
osteoblasts
mature bone cells
osteocytes
large cells that resorb or break down bone matrix
As bone resorbed, minerals released into blood
Similar to macrophage
osteoclasts
mitotic cartilage cells
chondroblasts
more mature cartilage cells
chondrocytes
i. Sites of Muscle and Ligament Attachment
bone marking
Projections
i. Lets things go through?
ii. Or hold up against?
iii. Conduit/canal for blood vessels and nerves
(bone marking type)
Depressions/Openings
One bone type is the dense outer layer; a.k.a. cortical bone
The other is honeycomb of trabeculae filled with bone marrow aka: woven bone, trabecular bone, cancellous bone
Compact Bone
Spongy Bone
Contains:
Diaphysis
Epiphyses
Long Bone
- Tubular shaft that forms the axis of long bones
- Composed of compact bone (cortical bone) that surrounds the medullary cavity
a. Yellow bone marrow (fatty) contained in medullary cavity
Long Bone
Diaphysis
- Expanded ends of the long bones
- Exterior is compact bone
- Interior is spongy bone
- Joint surfaces are covered with articular (hyaline) cartilage& perichondrium
- Epiphyseal Plate
- Epiphyseal Line
Long Bone
Epiphyses
Part of the Long Bone
a. Active hylaine Cartilage
b. Separates diaphysis from epiphyses until end of puberty
c. Ossifies –> growth ceases –> epiphyseal line
Epiphyseal Plate
Part of Long Boone
a. Detected on x-ray
b. Separates the diaphysis from the epiphyses after growth in length stops
c. The epiphyseal plate has been ossified. (after long bone growth stops)
Epiphyseal Line
- Bone Membrane
- Double layered protective membrane
1. Outer fibrous layer – Dense Irregular Connective Tissue
2. Inner Osteogenic (new) layer composed of osteoblasts and osteoclasts
3. Richly supplied with nerve fibers
a. This is the source of pain during bone fractures and bone bruises
4. Supplied with blood and lymphatic vessels, which enter the bone via nutrient foramina
a. A hole
5. Secured to the underlying bone by Sharpey’s fibers
Periosteum
- VERY delicate membrane covering internal medullary surfaces of bones
- Also osteogenic
Endosteum
Bones that form within tendons
Example includes the patella
Sesamoid bones
Bone Marking
rounded projection
Tuberosity
Bone Marking
narrow, prominent ridge of bone
Crest
Bone Marking
large, blunt irregular surface
Trochanter
Bone Marking
narrow ridge of bone
LineS
Bone Marking
small rounded projection
Tubercle
Bone Marking
Raised area above a condyle
Epicondyle
Bone Marking
Sharp, slender projection
Spine
Bone Marking
Any bony prominence
Process
Bone Marking
bony expansion carried on a narrow neck
Head
Bone Marking
Smooth, nearly flat articular surface
Facet
Bone Marking
Rounded articular projection
Condyle
Bone Marking
Arm like bar of bone
Ramus
Bone Marking
Canal like passageway
Meatus
Bone Marking
Cavity within a bone
Sinus
Bone Marking
Shallow, basin like depression
Fossa
Bone Marking
Furrow
Groove
Bone Marking
Indentation at the edge of a structure
Notch
Bone Marking
Narrow, slit like opening
Fissure
Bone Marking
Round or oval opening through bone
Foramen
i. Thin plates of periosteum-covered compact bone on the outside with endosteum-covered spongy bone (known as diploe) on the inside
ii. Have no diaphysis or epiphyses
iii. Contain red (hematopoietic) bone marrow between the trabeculae
Short/Flat/Irregular Bone Structure
i. Infants
1. Found in medullary cavity and every bone’s spongy bone
Childhood - red marrow slowly replaced by yellow marrow
ii. Adults
1. Only found in the diploe of flat bones
2. Head of the femur
3. Head of the humerus
Location of Hematopoietic Tissue (Red Marrow)
The structural unit of COMPACT bone
Osteon
Made of
LAmellae
Haversian canal
Volkmann’s canals
Osteon - structural unit of compact bone
Microscopic Structure of Compact Bone
a. Weight bearing, column-like matrix tubes
i. Composed mainly of collagen
ii. Osteon lamellae + interstitial lamellae + circumferentiale lamellae
Microscopic Structure of Compact Bone
Lamellae - Osteon
a. Central canal
b. Central channel containing blood vessels and nerves
Microscopic Structure of Compact Bone
Haversian canal
Osteon
Microscopic Structure of Compact Bone
a. Channels lying at right angles to the central canal
b. Connecting blood and nerve supply of the periosteium to that of the Haversian canal
Perpendicular to the Haversian canal
Microscopic Structure of Compact Bone
Volkmann’s canals
Microscopic Structure of Compact Bone
- Small cavities in bone that contain osteocytes
- Osteocytes – mature bone cells
Lacunae
Microscopic Structure of Compact Bone
1. Hair-like canals that connect lacunae to each other and the central canal
allow osteocytes to share nutrients and communicate
Cannaliculi
composed of proteoglycans, glycoproteins, and collagen
Un-minzeralized bone matrix composition
Osteoid
Osteoblasts Osteocytes Osteoclasts Osteoid The *LIVING* part of the bone
Organic Composition of Bone
i. Hydroxyapatites
1. Mineral salts
2. 65% of bone by mass
3. Primarily calcium phosphates
4. Responsible for
a. Bone hardness
b. Resistance to compression
Inorganic Composition of BOne
- The process of bone tissue formation, which leads to:
a. Formation of bony skeletons in embryos
b. Bone growth until early adulthood
c. Bone thickness
d. Bone remodeling
e. Bone repairing
Osteogenesis and Ossification
Bone Growth
a. “Within the membrane”
b. Formation of most of the flat bones of skull, the mandible, and part of clavicles
c. Recall the fibrous connective tissue membranes are formed by the mesenchyme cells
Intramembranous Ossification
a. Ossification center appears in the fibrous connective tissue membrane
i. This fibrous membrane is actually Dense Irregular CT
b. Bone matrix (osteoid) is secreted within the fibrous membrane
c. Bone (diploe) and periosteum form
d. Bone collar of compact bone forms and red marrow appears
e. In babies, this continues for awhile. The babies have soft spots of dense irregular connective tissue. Will continue to make bone
Stages of Intramembranous Ossification
- Bones form by replacing hyaline cartilage
- Formation of all long bones and most other bones of the body EXCEPT FLAT
- Uses hyaline cartilage templates or “models” for bone construction
- Requires the breakdown of hyaline cartilage prior to ossification
Endochondral Ossification
a. Primary ossification center develops in center of hyaline template
the epiphyseal cartilage on side closest to epiphysis is relatively INACTIVE.
b. Formation of periosteal (osteoid) bone collar
c. Calcification and Cavitation of the diaphysis hyaline cartilage
d. Invasoin of internal cavities by the periosteal bud, and spongy bone formation
e. Diaphysis elongates and medullary cavity forms
i. Plus the appearance of secondary ossification centers in the epiphyses
f. Ossification of the epiphyses, with hyaline cartilage remaining only in the epiphyseal plates
Endochondral Ossification
Steps
i. Cartilage continually grows and is replaced by bone
ii. Cartilage on the side of the epiphyseal plate closest to the epiphysis is relatively inactive
iii. Cartilage abutting the diaphysis (shaft) of the bone organizes into a pattern that allows fast, efficient growth
iv. Cells of the epiphyseal plate closest to the diaphysis form 3 functionally different zones
1. Growth
2. Transformation
3. Osteogenic
Growth in LENGTH of Long Bones
i. Appositional Growth – Bone is added by osteoblasts at the periosteal surface and resorbed by osteoclasts at the endosteal surface
ii. Allows for thicker, stronger bones without becoming too heavy.
1. How we remodel from fetal bone shape to adult bone shape.
Growth in WIDTH of Long Bones
i. Epiphyseal plate activity is stimulated by Growth Hormone
Hormones/Nutrients in Reg of Bone Growth/Maintenance
i. Testosterones and Estrogens
1. Initially promote adolescent growth spurts
2. Cause masculinization and feminization of specific parts of the skeleton
3. Later induce epiphyseal plate closure, ending longitudinal bone growth
Puberty Bone Growth and Maintenance
Gigantism
Bone Growth and Maintenance
Too much Growth Hormone
Pituitary Dwarfism
Bone Growth and Maintenance
Too Little Growth Hormone
a. When adjacent osteoblasts and osteoclasts deposit and resborb bone at periosteal and endosteal surfaces, respectively
1. Osteoblasts
a. Deposit bone at periosteal and endosteal surfaces
2. Osteoclasts
a. Resorb bone at periosteal and endosteal surfaces
Bone remodeling
i. Occurs where bone is injured or added or where added strength is needed
ii. Sites of new matrix deposition (By osteoblasts) are revealed by the
Bone Deposition
un-mineralized band of bone matrix
abrupt transition zone between the osteoid seam and the older mineralized bone
Osteoid seam
Calcification front
One week to calcify
osteoid
- Diet rich in
a. Protein
b. Vitamins
i. A
ii. C
iii. D
iv. K2
c. Calcium
d. Phosphorus
e. Magnesium
f. Manganese - Poor nutrition = weak bones and poor fracture healing
- Alkaline phosphatase is essential for the mineralization of bone
- Also mechanical stimulation (gravity loading)
Dietary Requirements for Calcification
i. Accomplished by osteoclasts
1. Essentially mobile phagocytes
ii. Resorption bays - grooves formed by osteoclasts as they break down bone matrix
iii. Resorption involves osteoclasts secretion of
1. Lysosomal enzymes that hydrolyze the organic matrix
2. Acids that convert calcium salts into soluble forms
iv. Dissolved matrix is transcytosed (“across the cell”) acorss the osteoclasts’s cell where it is secreted into the interstitial fluid and then into the blood
v. Osteoclasts then undergo apoptosis
1. Cell death
How does bone resorption work?
a. Body will add/remove as needed
i. Transmission of nerve impulses
ii. Muscle contraction
iii. Blood coagulation (clotting)
iv. Secretion by glands and nerve cells (neurotransmitters)
v. Cell division (mitosis/meiosis)
b. Homeostatic Mechanisms
i. Rising Blood calcium levels trigger the thyroid to release calcitonin
1. Stimulates calcium salt deposit in bone
ii. Falling Blood Ca levels triggers the parathyroid gland to release PTH
1. Signals osteoclasts to degrade bone matrix and relase Ca into the blood
Hormonal Mechanism/Control Loop to maintain Calcium homeostasis in the body
a. “a bone grows or remodels in response to the forces or demands placed upon it”
b. Few observations supporting this include
i. Long bone compact bone is thickest midway along the shaft
1. Where bending stress is greatest
ii. Curved bones are thickest where they are most likely to buckle
iii. Handedness (R or L) results in bones being larger in the dominant upper extremity
iv. Bony projections are largest where heavy, active muscles attach
c. Clinically used to maximize the healing of fractures.
Wolff’s law
- Bones retain their normal position
- Bone ends are out of normal alignment
- Bone is broken all the way through
- Bone is not broken all of the way through
i. Non-displaced Fracture
ii. Displaced Fracture
iii. Complete Fracture
iv. Incomplete Fracture
- The tracture I parallel to the long axis of the bone
2. Found often in prison escapees
Linear fracture
- Think perpendicular
2. The fracture is perpendicular to the long axis of the bone
Transverse
i. Comminuted
ii. Compression
iii. Spiral
Epiphysea
iv. Depressed
v. Greenstick
Common Types of Fractures
i. Comminuted
1. Bone fragments into three or more pieces
2. Common in the elderly
i. Comminuted
1. Bone fragments into three or more pieces
2. Common in the elderly
ii. Compression
1. Bone is crushed
2. Common in porous bones (of spine)
ii. Compression
1. Bone is crushed
2. Common in porous bones (of spine)
iii. Spiral
1. Ragged break when bone is excessively twisted
2. Common sports injury
a. Soccer players who already have a knee brace
iii. Spiral
1. Ragged break when bone is excessively twisted
2. Common sports injury
a. Soccer players who already have a knee brace
iv. Epiphyseal
1. Epiphysis separates from diaphysis along epiphyseal line
2. Occurs where cartilage cells are dying
iv. Epiphyseal
1. Epiphysis separates from diaphysis along epiphyseal line
2. Occurs where cartilage cells are dying
v. Depressed
1. Broken bone portion pressured inward
2. Typical skull fracture
v. Depressed
1. Broken bone portion pressured inward
2. Typical skull fracture
vi. Greenstick
1. Incomplete fracture where one side of the bone breaks and the other side bends
2. Common in children
a. Bones are more flexible
vi. Greenstick
1. Incomplete fracture where one side of the bone breaks and the other side bends
2. Common in children
a. Bones are more flexible
- Hematoma (blood pool formation)
- Fibrocartilaginous callus forms
- Bony Callus forms
- Bone remodeling
Healing a Bone Fracture
The steps
a. Torn blood vessels hemorrhage
b. Mass of clotted blood (the hematoma) forms at the fracture site
c. Site becomes swollen, painful, and inflamed
i. Due to highly innervated and highly vascularized periosteum
Healing a Bone Fracture
The steps
Hematoma