Exam 2 Flashcards
valence
repeated epitopes on the same pathogen
polyvalent
antigen/pathogen with many binding sites
—— epitopes trigger an immune response
immunogenic
affinity maturation occurs with Ig..
IgG
complement that binds to Fc of antibody, leading to classical pathway and MAC
C1q
70-80% of antibody in blood
IgG
5-10% of antibody in blood
IgM
first antibody made
IgM
10-20% of antibody in blood
IgA
70% of total antibody in body
sIgA
granzymes function
turn target cell’s proteins into DNA proteases
granulysin function
membrane-disrupting
works on intracellular bacteria
CD8 cells fight what kind of infections?
binding requires what?
bacterial intracellular infections
specific MHCI with specific antigen
recently-discovered antigen presenting molecule
CD1
functions like MHCI and presents glycolipids or lipoproteins
CD1
PAMP for CD1 is —–
lipid
proteosome/immunoproteasome function
processes antigens from a pathogen (usually a virus) for presentation on MHCI
antigens processed for —— presentation never touch the cytoplasm
MHCII
genus that can hide in the phagosome
Mycobacterium
CD8 binds to MHCI and produces —-, which incites an autocrine reaction
IL-2
CD4 T-cells bind to ——
MHCII
—- stimulates proliferation of CD4s before differentiation
IL-2
polarization to Th1 causes…
and requires… (4)
macrophage activation/cellular immunity
requires IL-2, IFN-y, IL-12, TGFB
polarization to Th2 causes…
and requires… (1)
humoral immunity
requires IL-4