EXAM 2 Flashcards
what are the 3 regulations that come with studying humans?
safety, efficacy, and ethics
what are the 2 cost that comes with studying humans?
participation and techniques
True or false: is it human nature to lie?
true
what are the 3 protected populations in regards to human research?
prisoners, children, and pregnant women
what is cell culture?
removing cells from their natural environment and growing them in artificial but more favorable one
what are the advantages of cell culture?
extreme level of environmental control, able to pick cell type, high throughput, ethical consideration
what are the disadvantages of cell culture?
cells in isolation, artificial environment, generational concerns
what is slice culture?
extraction and growth of portions of intact brain regions
what does ELISA stand for?
enzyme linked immunosorbent assay
what is ELISA?
plate based assay technique designed for detecting & qualifying soluble substances such as peptides, proteins, antibodies, and hormones
what is immunohistochemistry?
laboratory method that uses antibodies to check for certain antigens (markers) in a sample of tissue
what is an electron microscopy?
scanning electron microscope that produces 3D images
what is the function of confocal microscopy ?
produce a point source of light and reject out of focus light
what is the goal when selecting animals for research ?
to learn something about human condition, disease, or behavior
what are some considerations when selecting animals for research?
their normal behavior and a species limitations; species are good at certain things
what is operant conditioning?
an association learning process through which the strength of a behavior os modified by a reinforcement or a punishment
what are some types of reinforcers used by animals who conducting research?
food, drugs, and brain stimulation
what are mazes in animal research intended to study?
memory
what are two types of mazes used in animal research?
radial maze (8 arms) and t maze
True or False: rats prefer the dark
true
true or false: rats are visual driven
false - they are scent driven
what is stereotaxic surgery ?
minimally invasive surgical intervention used to locate small targets inside body and perform some action
what is a lesion?
region in an organ or tissue that has suffered damage either through injury or disease
what does DBS stand for
deep brain stimulation
chronic pain, Parkinson’s disease, epilepsy, OCD, depression, essential tremor: all can be treated with what?
DBS - deep brain stimulation
what is Parkinson’s disease?
brain disorder that causes unintended or uncontrollable movement; shaking, stiffness, and difficulty w balance and coordination
what is epilepsy?
CNS disorders in which brain activity becomes abnormal, causing seizure or periods of unusual behaviors, sensations or loss of awareness
how do we use neuroimaging?
to identify pathology and identify area in brain that shows activity during tasks
what is pathology?
study of the causes and effects of disease or injury; branch of medicine that deals in laboratory
what is cerebral angiography?
an injection of dye that differ in x-ray absorbance into blood vessel into vertebral artery
what does cerebral angiographies show?
cerebral vasculature and abnormalities
what does CT stand for
computed tomography
what is a CT
a diagnostic imagining procedure that uses combination of x-rays and computer technology to produce images on inside the body
how does a PET scan work
injection of radioactive sugar into carotid artery, measure of activity inside the brain, at rest vs doing an activity
how does an MRI work
uses magnetic field and computer generates radio waves to create detailed images on organs and tissue inside the body
what is the WAIS and what does it measure?
it measure intelligence and it works by placing card where you think it should go, you’ll be told yes or no and rules change
what is the token test and what does it measure
the token test measures language and you are instructed to touch specific shapes in a row; they’re different shapes, sizes, and colors
what are antibodies
proteins produced by white blood cells to destroy invading microorganism
what is Huntingtons disease?
rare, inherited disease that causes the progressive breakdown (degeneration) of nerve cells in the brain
what are skeletal muscles
muscles attached to the bone at each end, helping move the bone
what are tendons
a cord of strong flexible tissue, they connect your muscles to bones
what are joints
short band of tough flexible fibrous tissue that connects two bones, cartilages or holds joint
contraction of flexors that are TOWARDS are called?
flexion
contraction of extensors that are AWAY are called?
extensions
what is the function of alpha motor neurons?
to generate tensions by contracting
what are extramural muscle fibers?
standard skeletal muscle fibers that are innervated by alpha motor neurons
what are muscle spindles?
stretch receptors
what are intramural muscle fibers
muscle fibers in the skeletal muscle that detect changes in the length of the muscle
what is proprioception
a sensory receptor which receives stimuli from within the body, in other words the body’s ability to sense movement, action, location
what is the function of gamma motor neurons
regulate the gain of stretch reflex by adjusting the level of tension
how many muscle fibers are there and what are they?
3 types; SO, FO, FG
what is the function of myofibril
function to perform muscle contraction
what are actin and myosin
proteins found in muscle tissue that control voluntary muscular movements
what is a neuromuscular junction
synaptic connection between the terminal end of a motor nerve and muscle
what is acetylcholine
chemical messenger or neurotransmitter that plays vital role in muscle control
what are Golgi tendon organs
tree like structures in the tendons that encode stretch of muscles via firing rate
what is one way reflexes help?
reflexes help center of gravity
If there is no resistance when brain sends out command to move, what happens?
the intra and extrafusal are activated
what are the three cortical structures?
primary motor cortex, supplementary motor area, and premotor cortex