Exam 1 - Gastrointestinal Pharmacology Flashcards
what is the ACVIM consensus statement on gastroprotectants?
consensus opinion on the rational administration of GI protectants to dogs and cats, with an emphasis on proton pump inhibitors (PPIs), histamine type-2 receptor antagonists (H2RAs), misoprostol, and sucralfate. These medications decrease gastric acidity or promote mucosal protective mechanisms, transforming the management of dyspepsia, peptic ulceration, and gastroesophageal reflux disease
judicious use of acid suppressants is warranted considering recent studies that have documented adverse effects of long-term supplementation of PPIs in people and animals
basically we over use PPI & should do better when considering what drugs are indicated & why
what is the mechanism of action of maropitant?
NK-1 receptor antagonist - acts in the CNS by prohibiting the binding of substance p
what is the mechanism of action of ondansetron?
serotonin antagonist - 5HT3
site of action at the CRTZ & peripheral vagal afferent nerves
what is the mechanism of action of famotidine?
H2 receptor antagonist - works at the H2 receptors in the parietal cells competitively inhibiting histamine to reduce gastric acid production
what is the mechanism of action of omeprazole?
proton pump inhibitor - inhibits the H+K+-ATPase pump of the parietal cells to decrease gastric acid production
what is the mechanism of action of misoprostol?
PGE1 analogue - prostaglandin analogue
provides mucosal defense through decreasing gastric acid production & increasing bicarbonate production
what is the standard of care for treating gastroduodenal ulceration?
proton pump inhibitor
T/F: acid suppressant drugs are not anti-emetics
true - not all vomiting dogs need them
what is the mechanism of sulcralfate?
gi mucosal protectant - reacts with HCl acid & forms a paste on damaged lesions of gi mucosa
when is sucralfate indicated?
there has to be damaged lesions in the gi tract for it to bind & actually work - if there is no damaged lesions, no point in giving it
