Exam 1: Chapter 4: Physiological Development and Epigenetics Flashcards

1
Q

Hooded seals

A
  • mothers give birth on sheet of ice
  • nurse for 3 days
  • remain on ice, must look for own food
  • ability to dive is really important
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2
Q

Hooded seals (oxygen)

A
  • ability to store O2 is important for diving
  • oxygen is stored in tissues of the animal
  • oxygen is stored in the lungs
  • oxygen is stored in blood attatched to hemoglobin
  • oxygen attatched to myoglobin is used to swim
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3
Q

Underdeveloped muscles in hooded seals causes:

A

less myoglobin to be present, allowing for less oxygen storage which results in shorter dive times

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4
Q

How long do young hooded seals dive compared to adults?

A

young: 2 to 5 mins each time, 14 short dives/hr
adult: 5 to 25 mins each time, 4 dives/her

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5
Q

How are young hood seal dives different from adults?

A

dive shallowed distances with limited hunting success

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6
Q

Young hooded seals must succeed to…

A

become a reproductive adult

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7
Q

Young hood seals spend how much of their time underwater feeding?

A

90%

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8
Q

How does the physiology of immature animals differ from that of an adult?

A
  • tissues and organs develop at different rates
  • brain isn’t mature until about 7 years
  • general body tissues are about half that
  • mammals tend to push things off until after birth
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9
Q

How does lab rat physiology different from other mammals?

A

reproductive organs mature before the brain to ensure reproduction takes place (adaptation)

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10
Q

How much energy does the brain use?

A

In adults, the brain is 20% of the metabolic rate, even through it takes up about 2% of body mass.
At the age of 4-5, 50% of a childs metabolism goes to brain development (half the food they eat); starvation at this age has greater effects on the brain.

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11
Q

What is needed in children for proper brain development?

A

adequate food and nutrition

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12
Q

How do males and females different in development?

A

males and females mature reproductively at different rates

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13
Q

homeothermy

A

having a relatively uniform body temperature maintained nearly independent of the environmental temperature; develops as animals age, depend on the warmth of the mother before they can thermoregulate

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14
Q

Thermoregulation in mice:

A

not able to do so until about 3 weeks; over 3 week nesting time, they become adults, generate heat, grow fur, and resist heat loss

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15
Q

what happens to enzymes during tissue development

A

enzymes are upregulated; can have an effect on cell metabolism

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16
Q

Early fetal rats can’t synthesize _________ due to _______.

A

liver glycogen; lack of glycogen synthase

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17
Q

Production of glycogen synthase in rats begins…

A

5 days after birth; newborn rats can then synthesize liver glycogen

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18
Q

3 waves of gene expression

A

right before birth, at birth, after birth

each wave is upregulated differently

19
Q

how are mRNAs regulated during development?

A

sequentially

some are coded for enzymes shown previously

20
Q

different sets of genes are transcribed…..

A

at different times during development

21
Q

Phenotype plasticity:

A

an animals phenotype is changeable; common in development

22
Q

Different environments can cause

A

phenotype plasticity

23
Q

How has menarche changed?

A

occurs earlier now than in the past; changed due to improved nutrition, public health, and medical care

24
Q

Give an exam of how height can be show phenotypic plasticity

A

British factory children and those in a medieval village were shorter than recent children; harsh living conditions and improper nutrition are thought to be responsible

25
epigenetics
changes to gene expression with no changes to the DNA sequence; passed down through generations
26
how are epigenetic marks created?
by environmental events, attached to the DNA
27
epigenetic can cause changes to...
gene expression; can be positive or negative
28
CH3 epigenetic markers
methylate cytosines; DNA can't be opened for transcription and replication
29
how can methylation be passed on?
through mitosis; the methylation is replicated when the DNA is replicated during mitosis
30
When epigenetic changes occur during embryonic development, it will be passed on....
to all cells of the organism | can then be passed to offspring
31
example of negative epigenetic changes
changes caused by smoking and second hand smoke
32
two types of epigenetic marks
DNA methylation and covalent modification of histone proteins
33
what does cytosine methylation in DNA cause?
acts to silence gene expression
34
methyltransferase
helps to retain the marks to the new generation during replication of DNA
35
what can modify histone proteins?
methylation, acetylation, phosphorylation, and others
36
methylome
all the methylated DNA locations
37
epigenetic inheritance can be
individual or transgenerational
38
during development when cells migrate to their target they begin to....
differentiate
39
with terminal differentiation
cells gene expression is altered; each expressed a subset of their genes specific to their function
40
malnutrition affect on methylation
causes reduced methylation; | example- malnutrition in the netherlands during WW2
41
Effects of suffering malnutrition in early life
higher levels of gene expression as adults | shown to result in cardiovascular and metabolic disease later in life
42
example of lifelong effects of early-life stress
studies have shown high rates of obesity and coronary artery disease
43
intermediate in the methylation process
folic acid; lack of folic acid cases decreased sites of methylation
44
methylation of oncogenes
results in less chance of cancer; without that cancer could result