Exam 1: Body Fluid Compartments Flashcards
What 6 things are soluble in water?
- Ions (electrolytes)
- Proteins (some)
- Carbs - charged compounds such as glucose
- Gases - CO2 is water soluble while Nitrous is not
- Buffers - help keep pH in a defined range
- Drugs (some)
What is the difference between hydrophilic and hydrophobic?
-Philic = water loving; usually charged
Ex: Na+, K+, Cl
-Phobic = water hating; uncharged
Ex: Fats
What 4 things are insoluble in water?
- Cholesterol
- Steroid hormones
- Lipids
- Drugs (others) - require carriers/carrier proteins to get around CV system
What is the water inside of cells called?
ICF - intracellular fluid
What is the fluid outside of cells called?
ECF - extracellular fluid
What fluids combine to create the ECF?
Interstitial fluid and plasma
Which compartment holds more water? ICF or ECF.
ICF
How much of the overall body content does water take up?
60% of the body mass
If a patient weighs 100kg how much of the body is water?
60 kg
What fractions can you split ICF and ECF into?
ICF is 2/3 of the body while ECF is 1/3 of the body weight
How much of the ECF is made up of plasma?
1/4 - 1/5
When you lose fluid or blood, where does fluid shift from to help compensate?
Fluid will shift from the interstitial fluid to the plasma to help make up for any loss
Which two barriers split up the ICF and ECF?
The capillary membrane splits up the interstitial fluid from the plasma and the cell membrane separates the ICF from the ECF
Is the capillary membrane permeable?
The capillary membrane is fairly permeable and more porous than the cell membrane. It allows small charged ions between the plasma and interstitial fluid; the wall is tight enough to prevent leaking from the CV system
Generally, capillary membranes are fairly permeable. Name an exception to where these capillaries would want to be tight.
Brain capillaries would benefit from being tight to prevent proteins from leaking
