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Pharm Fall 2019 > Ex1 Propofol Slides > Flashcards

Ex1 Propofol Slides Flashcards

1
Q

Unconsciousness occurs after

A

30s

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2
Q

Pain on injection d/t

A

Small veins, metabisulfite

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3
Q

Advantage of propofol

A

Awakening after bolus injection is more rapid and complete than with any other induction agent

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4
Q

MOA propofol

A

Decreased rate of dissociation of GABA from receptor
Increased duration of GABA mediated chloride conductance
Neuronal hyperpolarization
Inhibits ACh in hippocampus/frontal cortex
NMDA inhibition

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5
Q

Induction dose

A

1.5-2.5 mg/kg IV

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6
Q

Pediatric induction dose

A

2-3 mg/kg IV

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7
Q

Why do children require larger doses?

A

Larger central distribution

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8
Q

Why do elderly require lower doses?

A

Smaller central distribution, Low clearance

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9
Q

Awakening from propofol occurs due to?

A

Redistribution of drug out of the brain (VRG) to the muscle and fat

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10
Q

Brain concentration of propofol peaks at?

A

1 minute

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11
Q

Awakening at plasma concentration of?

A

1-1.5 mcg/ml

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12
Q

Maintenance dosage

A

100-300 mcg/kg/min

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13
Q

Pediatric maintenance dosage

A

60-250 mcg/kg/min

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14
Q

Downside of propofol?

A

No analgesic properties

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15
Q

Compared to volatile agents, how is recovery time?

A

Modest decrease in recovery time

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16
Q

MAC dose

A

25-100 mcg/kg/min

17
Q

Benefit of propofol use

A

Low incidence of PONV

18
Q

Effects on CNS

A

Decreased CMRO2, CBF, ICP
Cerebral auto regulation unaffected
Amnesia similar to midazolam at similar dose

19
Q

CV effects

A

Decreased SBP, CO, SVR (>STP)
*destroys sympathetic tone
Decreased preload/myocardial contractility

20
Q

Propofol is avoided in which types of cases?

A

EP lab - suppression of SVT

21
Q

Respiratory effects

A

Dose dependent depression of ventilation
Decreased VT, RR
Bronchodilation
Decreased vent response to CO2 & hypoxemia

22
Q

_____% of patients become apneic

A

30

Pharm Fall 2019 (33 decks)

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