Ex1 Kaboom Questions Flashcards

1
Q

Substitution of the 5 carbon atom of barbaturic acid with a branched chain results in

A

Greater hypnotic activity

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2
Q

Lactic acidosis with propofol infusion is associated with:

A

Defeats in the mitochondrial respiratory chain

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3
Q

What would be the appropriate IV induction dose of propofol for a 40 year old patient?

A

2mg/kg

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4
Q

What infusion dose of propofol is required to produce general anesthesia in pediatric patients?

A

200-300 mcg/kg/min

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5
Q

The termination of action of thiopental and methohexital is due to?

A

Redistribution

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6
Q

During induction, etomidate may cause a decrease in blood pressure due to a decrease in?

A

SVR

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7
Q

Which of the following are produced by the administration of ketamine?

A

An increase in cerebral oxygen concentration

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8
Q

Which of the following would be an acceptable IM induction dose of ketamine in a 50kg patient?

A

250mg

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9
Q

What is an appropriate IV induction dose of thiopental for a 30 kg 7 year old patient?

A

150 mg

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10
Q

IV thiopental and propofol both will?

A

Decrease cerebral blood flow

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11
Q

What is true about butorphanol?

A

Produce analgesia and antishivering effects

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12
Q

Which active metabolite of morphine causes analgesia and depression of ventilation?

A

Morphine 6 glucoronide

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13
Q

Which is false about opioid agonist tolerance?

A

Increased activity of protein kinase

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14
Q

The ability of a drug to bind with a receptor to form a stable complex is referred to as?

A

Affinity

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15
Q

The dose response curve produced by the binding of an opioid to an opioid receptor represents?

A

Efficacy

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16
Q

By what principal mechanism does morphine produce nausea?

A

Stimulation of chemoreceptors trigger zone (CTZ)

17
Q

Remifentanyl is metabolized by

A

Non-specific esterases

18
Q

Which opioid would not be recommended for use in a patient with a history of epilepsy?

A

Alfentanil

19
Q

Which agent reverses opioid-induced respiratory depression by acting on carotid chemoreceptors?

A

Doxapram

20
Q

Which of the following agents could result in severe withdrawal in opioid-dependent patient?

A

nalbuphine

21
Q

Drug of choice when rapid/complete awakening is desired?

A

Propofol

22
Q

Which has the quickest onset?
Lorazepam
Diazepam
Midazolam

A

Midazolam/Diazepam

30-60s

23
Q

Which has the longest duration of action?
Lorazepam
Diazepam
Midazolam

A

Diazepam

24
Q

Which has the smallest volume of distribution?
Lorazepam
Diazepam
Midazolam

A

Lorazepam

25
Q

Which has the highest potency?
Lorazepam
Diazepam
Midazolam

A

Lorazepam

26
Q

Which has the quickest E1/2t?
Lorazepam
Diazepam
Midazolam

A

midazolam