Ex1 Kaboom Questions Flashcards
Substitution of the 5 carbon atom of barbaturic acid with a branched chain results in
Greater hypnotic activity
Lactic acidosis with propofol infusion is associated with:
Defeats in the mitochondrial respiratory chain
What would be the appropriate IV induction dose of propofol for a 40 year old patient?
2mg/kg
What infusion dose of propofol is required to produce general anesthesia in pediatric patients?
200-300 mcg/kg/min
The termination of action of thiopental and methohexital is due to?
Redistribution
During induction, etomidate may cause a decrease in blood pressure due to a decrease in?
SVR
Which of the following are produced by the administration of ketamine?
An increase in cerebral oxygen concentration
Which of the following would be an acceptable IM induction dose of ketamine in a 50kg patient?
250mg
What is an appropriate IV induction dose of thiopental for a 30 kg 7 year old patient?
150 mg
IV thiopental and propofol both will?
Decrease cerebral blood flow
What is true about butorphanol?
Produce analgesia and antishivering effects
Which active metabolite of morphine causes analgesia and depression of ventilation?
Morphine 6 glucoronide
Which is false about opioid agonist tolerance?
Increased activity of protein kinase
The ability of a drug to bind with a receptor to form a stable complex is referred to as?
Affinity
The dose response curve produced by the binding of an opioid to an opioid receptor represents?
Efficacy
By what principal mechanism does morphine produce nausea?
Stimulation of chemoreceptors trigger zone (CTZ)
Remifentanyl is metabolized by
Non-specific esterases
Which opioid would not be recommended for use in a patient with a history of epilepsy?
Alfentanil
Which agent reverses opioid-induced respiratory depression by acting on carotid chemoreceptors?
Doxapram
Which of the following agents could result in severe withdrawal in opioid-dependent patient?
nalbuphine
Drug of choice when rapid/complete awakening is desired?
Propofol
Which has the quickest onset?
Lorazepam
Diazepam
Midazolam
Midazolam/Diazepam
30-60s
Which has the longest duration of action?
Lorazepam
Diazepam
Midazolam
Diazepam
Which has the smallest volume of distribution?
Lorazepam
Diazepam
Midazolam
Lorazepam
Which has the highest potency?
Lorazepam
Diazepam
Midazolam
Lorazepam
Which has the quickest E1/2t?
Lorazepam
Diazepam
Midazolam
midazolam
