Ex 1 Etomidate Slides

Question 1

Etomidate induction dose

Answer 1

0.2-0.4 mg/kg IV bolus

Question 2

Etomidate is advantageous in what type of patient?

Answer 2

Unstable CV status

Question 3

Utilization of etomidate is limited by

Answer 3

HPA axis depression

Does not produce analgesia

Question 4

CNS effects

Answer 4

Cerebral vasoconstriction
Decreased CBF, CMRO2, ICP, IOP
May cause myoclonus/hiccups

Question 5

CV effects

Answer 5

No effect on SNS/baroreceptors
Minimal changes in HR/SVR/CO/CI/SV
Myocardial O2 req/myocardial blood flow is halved
Platelet inhibition (increased bleeding time)

Question 6

Effects on respiratory system

Answer 6

Mild respiratory depression
No histamine release
May be appropriate choice when spontaneous ventilation is desired

Question 7

Patients that should not receive etomidate

Answer 7

Septic, shock, trauma patients, Addisonian Crisis/acute adrenal failure

Question 8

Reason for decreased HPA depression

Answer 8

Inhibition of 11Beta-Hydroxylase

Question 9

Adverse effects of etomidate

Answer 9

N/V - 35%
Pain on injection
Phlebitis
Hemolysis from propylene glycol (resulting in toxicity/hyperosmolality)

Question 10

CNS effects of etomidate include: (select 2)
Myoclonus
Analgesia
Cerebral vasodilation
Decreased ICP

Answer 10

Myoclonus & decreased ICP