Evolution Flashcards
evolution 1
- All life forms are derived from previous life forms
- Genetic variation underlies evolutionary change
- Evolution yields anatomical and functional alterations over time
- changes in anatomy and function!
- Adaptation is specialization in response to particular environment
- Speciation is formation of distinct, reproductively isolated, life forms
Speciation
Speciation is formation of distinct, reproductively isolated, life forms
Reproductively isolated is how species are defined, life forms
Genetic variation
Random mutation produces genetic variation
Polymorphisms = sequence changes of different alleles
Gene pool = collection of all alleles for all genes in a population, ALL GENES IN POPULATION
Population = all individuals of a species in the same place at the same time, in same place at the same time*** not technically part of the same population of people who lived in NY 200 years ago**
Polymorphism
= sequence changes of different alleles, may have nothing to do with genes for different traits; even in parts of DNA can identify polymorphism in population some ppl have letters AAA in that spot, some have AAAT just part of variation you find in a population
Gene pool
Gene pool = collection of all alleles for all genes in a population, ALL GENES IN POPULATION
Definition of population
Population = all individuals of a species in the same place at the same time, in same place at the same time*** not technically part of the same population of people who lived in NY 200 years ago**
Genetic equilibrium
- means no evolution going on no change in allele frequency
- pretty rare and maybe impossible to be in genetic equilbirum forever, but true enough for periods of time that the model is worth using sometimes*
- so in order for a population to be in genetic equilbirum:
- Mating is random
- NO MUTATIONS, no net mutation
- Large population size
- NO migration in or out of population
- NO natural selection
Genetic equilibrium 2
Genetic equilibrium = no evolution = no change in allele frequency
Five conditions must be met for genetic equilibrium
Mating is random
Net rate of mutations is zero (i.e., A ← → a equal)
Large population size
No migration in or out of population
No natural selection
payoff for making these assumptions can use hardy weinberg assumptions/equations
Hardy-Weinberg equilbirum
key here p and q represent frequencies of alleles,
p dominant allele; q recessive allele will be decimals of less than 1
like .2 and .8= 1 which is 100% of alleles for that genetic locus in the population, we are assuming here in this version of Hardy Weinberg assuming only too alleles for this gene** we know out there there are some genes where there are more then 2 allleles, but Hardy-Weinberg assumes 2 for dominant and recessive
Hardy-W equ. 2
Hardy-Weinberg (HW) principle governs allele frequencies during genetic equilibrium
HW as applied to a two allele system (Bb):
p = allele frequency of dominant allele (B)
q = allele frequency of recessive allele (b)
p+ q= 1
Example: 75 BB, 125 Bb, 50 bb animals in population; p = 275/500, q = 225/500
Punnett square with allele frequencies dictates that square of equation is also true:
p2 + 2pq + q2 = 1 p2 = freq BB 2pq = freq Bb q2 = freq bb
Therefore, allele frequency is constant in each generation
Can calculate all frequencies from frequency of recessive phenotype (q2)
Hardy-Weinberg eq 3.
p2 + 2pq + q2 = 1
p2 = freq BB 2pq = freq Bb q2 = freq bb
Therefore, allele frequency is constant in each generation
Can calculate all frequencies from frequency of recessive phenotype (q2)
THE frequency of those genotypes and individuals in population, so first equation p+q=1 tells you abotu frequency of the alleles, this other equation tells you about hte frequency of different kinds of people or animals of genotypes you find in the population
for ex. this equation tells us if maybe individual homozgyous domiant, homo recessive, hetero of allele etc.. if you want to know frequency of homozygote individual is p2, homozgous recessive is the q2
if studying population homozgous recessive disease, if out of 100 ppl in population 1 person has the disease, telling you .01 is q2 which is by the easiest thign to measure in population; usually way in the easiest thing to tell, if see how many individuals in population have recessive phenotype and make it a decimal that is giving you q2, can also look at a populaton and see what portion of people have the domiannt genotype but not as helpful information do not know if homozgoute or heterozgyote, can be part of p2 group or 2pq cannot tell unless squence genomes, but if showing up with homogzgote recessive knwo genotype if know q2 can find q then find 2+p =1 then find p….
Frequency in HWE
if they say 20 individuals out of 100 have homoz. recessive genotype or homozgous recessive then 20 out of 100 would be genotype too, then the frequency would be 20/100 but make it a decimal so .2
same if population has 200 ppl, 40/200 would also be hte same as 20/100 also .2 in this case for the frequency in this case*
so may have to set up that fraction in order to get the frequency and then onc eyou have the frequency that decimal can use hardyweinberg equation
Evolution if violate any of the 5 things….
if violate any of 5 things mentioned population is evolvign! so if net rate of mutaiton is greater than zero, or population size is really small get what is calld genetic drift or migration in or out also called gene flow can change new people coming in means no combination of alleles coming in
Genetic equilibrium ≠ evolution
During evolution, allele frequencies are changing
If any one of five conditions is occurring in a population, evolution is occurring:
Net rate of mutation > 0
Natural selection
Mating is nonrandom (sexual selection)
Small population size (facilitates genetic drift)
Migration in and out of population (gene flow)
natural selection
Natural selection is the major driving force for evolution
Acts on PRE-EXISTING genetic variation in population
Selection increases frequency of helpful traits, decreases negative traits
Selects for individuals, not the group as a whole
Group selection (idea that evolution can sometimes select for group) is controversial
natural selection 2
watch out on mcat- say being treated with a certain antibiotic, the antiobiotic kills 99% of the bacteria causing your infection but 1% of that bacteria by random lucky chance has some mutaiton allows you to resist antibiotic being treated with so the presence of that antibiotic is then creating a selection pressure favoring bacteria that have resistance gene and can thrive even in the presence of that antibiotic so then the resistance bacteria will proliferate and become the dominant form of bacteria in your system overtime** MCAT will definitely test that concept but the way you would describe what is happening selection pressure in favor of resistant bacteria cells, or can say cells able to grow in the presence of antibitoic were favored, thrived able to pass down genes
what would be the wrong answer choice would be to say when antibiotic was intrdocued that CAUSSED some genes to mutate that caused mutations NOO just favors mutaitons that some lucky little cells happen to have because of sponatenous mutaiton*** doesn’t cause it it favors***
Fitness
The more an organism or individual passes on its genes the more fit it is! so the way this has been tested on the MCAT which of the following individuals i teh most fit, 18 year old track star or 85 grandma with arthritiss, in this context the grandmother is more fit than the kid because she has passed on her gene more***
test difference btw evolutionary fitness and atheltic fitness under other circumstances*
Fitness 2
Reproduction generally yields more offspring than can be supported by environment
Fitness reflects ability of an individual to survive and reproduce
Two components of fitness: mortality and fecundity
Mortality = death
Fecundity = # of offspring
Fitness is specific to a particular environment
Drought resistant plants are more fit in desert, but not in rainforest
If organism has higher fitness than peers, frequency of its alleles will increase
Fecundity
Fecundity = # of offspring
Inclusive fitness
A gene maximizes its chance of survival by promoting the survival and reproduction of similar and closely- related individuals
Related to the concept of kin selection
Used to reconcile cooperation between organisms with the idea that genes “selfishly” promote their own survival
Example: animals sacrificing themselves so that a group of relatives survive. Ultimately, this will cause more copies of their genes to exist
Inclusive fitness 2
From darwin’s point of view, want to pass on our genes! But it is allso true when our siblings or cousins have kids we want this, the idea of inclusive fitness takes that into account sometimes we will make sacrifices for other members of our family from darwin point of view can explain that by saying when our relatives reproduce genes that we share with them are getting passed down so can make sense of it even from within this very genetically focused perspective
Nonrandom mating
In environment, mating is generally nonrandom = sexual selection
Some phenotypes are preferred mates
Individuals may prefer phenotype similar to their own → positive assortative mating
Individuals may prefer phenotype dissimilar to their own → negative assortative mating (opposites attract)
Preferred mates have higher fecundity (average # offspring) more genetically productive kind of mating*
genetic drifit
change in allele frequencies that are not just random, when populations are small tend to be changes in allele frequency because of genetic drift
2 examples: bottleneck effect and founder effect