Every MOA Flashcards
Heparin
inactivates factors Xa and ii resulting in inhibition of thrombin preventing clotting factors.
Warfarin
Inhibits synthesis of Vit K dependent clotting factors
GTN spray
Binds to nitrate receptors in vascular smooth muscles - vaso/venodilation of arteries, increasing oxygen to myocardium.
Aspirin
Inhibits COX1 which inhibits platelet aggregation and vasoconstriction
Digoxin
Inhibits the Na+ and K+ pump which increases intracellular sodium, increasing calcium to the heart
Enalapril
Blocks the enzyme required for converting angiotensin 1 to 2, resulting in decreased vascular tone
Beta blockers - Metopoprolol, Propranolol
Bind to B receptors in the autonomic NS, preventing adrenaline and noradrenaline stimulating receptors
Furosemide
Inhibits the reabsorption of sodium chloride and other electrolytes in renal tubules
Simvastatin
Inhibits synthesis of cholesterol in the liver
Metformin
Increases glucose re-uptake and utilisation in the skeletal muscles and reduces re-uptake in the liver
Empagflozin
Acts on sodium glucose co-transporters in the renal tubules to inhibit reabsorption of glucose
Stimulant laxatives- biscadyl and Docusate sodium
irritate the bowel to increase gut motility and decrease water absorption
Bulk forming laxative - psyllium husk
absorbs water in intestines
Osmotic laxatives - lactulose
Draws water into the lumens and intestines, increases stool volumes and triggering motility
Stool softener - Docusate sodium
Lowers the surface tension at the oil-water mix of faeces, so water and lipids can get into stool