Every MOA Flashcards

1
Q

Heparin

A

inactivates factors Xa and ii resulting in inhibition of thrombin preventing clotting factors.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Warfarin

A

Inhibits synthesis of Vit K dependent clotting factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

GTN spray

A

Binds to nitrate receptors in vascular smooth muscles - vaso/venodilation of arteries, increasing oxygen to myocardium.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Aspirin

A

Inhibits COX1 which inhibits platelet aggregation and vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Digoxin

A

Inhibits the Na+ and K+ pump which increases intracellular sodium, increasing calcium to the heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Enalapril

A

Blocks the enzyme required for converting angiotensin 1 to 2, resulting in decreased vascular tone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Beta blockers - Metopoprolol, Propranolol

A

Bind to B receptors in the autonomic NS, preventing adrenaline and noradrenaline stimulating receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Furosemide

A

Inhibits the reabsorption of sodium chloride and other electrolytes in renal tubules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Simvastatin

A

Inhibits synthesis of cholesterol in the liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Metformin

A

Increases glucose re-uptake and utilisation in the skeletal muscles and reduces re-uptake in the liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Empagflozin

A

Acts on sodium glucose co-transporters in the renal tubules to inhibit reabsorption of glucose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Stimulant laxatives- biscadyl and Docusate sodium

A

irritate the bowel to increase gut motility and decrease water absorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Bulk forming laxative - psyllium husk

A

absorbs water in intestines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Osmotic laxatives - lactulose

A

Draws water into the lumens and intestines, increases stool volumes and triggering motility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Stool softener - Docusate sodium

A

Lowers the surface tension at the oil-water mix of faeces, so water and lipids can get into stool

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Omperprazole

A

Binds irreversibility to the gastric proton pump in parietal cells to prevent the release of gastric acid

17
Q

Ondansetron

A

Binds to 5HT receptors in CTZ, GI tract, vomiting reflex centre to inhibit the vomiting reflex

18
Q

Metoclopramide

A

Blocks D2 receptors in CTZ and vomiting centre reducing vomiting reflex

19
Q

Cyclizine

A

Blocks H2 receptors and has anticholinergic effects

20
Q

Short and long acting beta 2 agonists (Salbutamol and Salmeterol)

A

Stimulates Beta 2 receptors in bronchial smooth muscles causing bronchodilator

21
Q

Anticholinergics e.g ipratropium tiotropium

A

muscarinic agonist, blocks parasympathetic stimulation in vagus nerve resulting in bronchodilaton and relaxation

22
Q

Inhaled corticosteriods e.g fluticasone

A

Mimics the action of natural glucosteroids, the stress hormone released from the adrenal gland

23
Q

Amoxicillin

A

interferes with the bacterial cell wall structure, inhibits cell well synthesis causing lysis and cell death (bactericidal)

24
Q

Ibuprofen

A

Non-Selective reversible inhibitor of COX1 and 2 enzymes

25
Paracetamol
Has local and central action Local inhibits COX Central inhibits prostaglandin synthesis
26
Morphine
Activation of descending inhibitory pathway from CNS, inhibition of nociceptive afferent neutrons
27
Tramadol
Stimulates the MU receptors
28
Loperamide
Binds to the opiate receptors in the gut wall, reducing propulsive peristalsis