epilepsy + seizures Flashcards

1
Q

which conditions have an assoc with epilepsy

A

cerebral palsy // tuberous sclerosis // mitochondrial disease

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2
Q

where do focal vs generalised seizures occur

A

focal = localised part of the brain, 1 sided // generalised = all parts of brain imparied, both sides

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3
Q

RF for developing epilepsy

A

brith and development, past seizures, head injury, FH

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4
Q

stages of a seizure

A

aura (maybe) –> seizure –> post-ictal

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5
Q

what are focal aware (simple) seizures

A

focal seizures affecting one side of the brain –> symptoms correlate with area of brain –> awareness usually not impaired

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6
Q

frontal lobe focal seizure symptoms

A

motor movement // jacksonian march - clonic movements start distally and move proximally

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7
Q

parietal lobe focal seizure symptoms

A

sensory signs

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8
Q

occipital lobe focal seizure symptoms

A

visual flashes, hallucinations

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9
Q

what are focal impaired awareness (complex) seizures + symptoms

A

aura (rising epigastric feeling) // LOC // repetiitve movement usually lip smacking, grabbing // last 1 min // post-ictal confusion

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10
Q

where do focal impaired awareness seizures usually occur in brain

A

temporal lobe

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11
Q

symptoms absence seizures

A

abrupt LOC and patient stares into space // tone preserved // no post-ictal confusion // lasts 10 secs

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12
Q

who usually gets absence seizures

A

girls aged 3-10

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13
Q

EEG absence seizure

A

3Hz bilateral wave pattern

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14
Q

symptoms myoclonic seizures

A

brief muscle contractions in small groups of muscles –> a single jerk

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15
Q

what are symptoms of juvenile myoclonic eplipesy + what age

A

12-18 // brief myoclonic jerks // happens in morning or when sleep deprived // daytime abscence

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16
Q

what does juvenile myoclonic epilepsy usually develop too

A

tonic-clonic

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17
Q

symptoms tonic seizure

A

brief LOX –>fall –> extended neck and back, stiff body

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18
Q

symptoms clonic seizure

A

repeated myoclonic movements // parts of body shake and jerk frequently

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19
Q

phases tonic clonic seizures

A

tonic: LOC, fall, tongue biting, incontinence // clonic: start to jerk around, eyes roll back // post-ictal confusion + headache

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20
Q

what are secondary seizures

A

when previous focal seizures spread to bilateral general seizures

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21
Q

general symptoms post-ictally

A

headache, drowsy, confused for around 15 minutes

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22
Q

invx seizures

A

ECG!! // MRI // EEG

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23
Q

mx tonic-clonic seizures

A

1 = sodium valproate // 2 = lamotrigene or levetiracetam

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24
Q

mx absence seizures

A

1 = ethosuximide // 2 = sodium valpraote, lamotrigene or levetiracetam

25
mx myoclonic seizures
1 = sodium valproate // 2 = levetiracitam
26
mx tonic seizures
1 = sodium valproate // 2 - lamotrigine
27
mx focl seizures
1 = lamotrigene, levetiracetam // 2 = carbamazepine
28
SE sodium valproate
teratogenic // P450 inhibitor // alopecia
29
carbamezepine SE
p450 inducer // dizzy, drowsy // ataxic // SIADH // visual disturbance
30
SE phenytoin
p450 inducer // ataxia // coarse facial features // peripheral neuropathy // gingival hyperplasia
31
mechanism + SE lamotrigiene
Na channel blocker // stevens johnson
32
what age do febrile convulsions occur at
6 months - 5 years
33
simple febrile convulsion symptoms
general (tonic clonic) // < 15 mins // no recurrence
34
complex febrile convulsion symptoms
15-30 mins // focal seizure // may have repeat seizures
35
immediate mx febrile seizure
phone ambulance if more than 5 mins // anti pyretics do not reduce change
36
mx recurrent febrile convulsion
rectal diazepam or buccal midazolam
37
what is status eplipticus
seizure >5 mins OR >2 seizures within 5 mins
38
1st, 2nd, 3rd line mx status elipticus
1 = IV benzo eg lorazepam // 2 = add on phenytoin or phenobarbitol // 3 = general anaesthesia
39
when can benzos be repeated in status elipticus
after 10-20 mins, only once
40
inital mx status elipticus in community
rectal diazepam or buccal midazolam
41
adult dose rectal diazepam status elipitucs
10-20mg (max 30)
42
adult dose buccal midazolam status elipitucs
10mg
43
what should all women with epilepsy take prior to pregnancy
5mg folic acid
44
risk to baby with sodium valproate
neural tube defect
45
risk to baby with phenytoin
cleft palate
46
if a pregnant women is taking phenytion what should be given in last month of pregnancy
vit K
47
safest AED pregnancy
monotherapy lamotrigine
48
is breast feeding safe on AEDs
yes - except barbiturates
49
which contraception is adviced for women on AED
copper coil or depo injfection
50
what contraception is UKMEC3 taking AEDs
COCP + POP (not for lamotrigene)
51
symptoms pseudoseizure
gradual onset // pelvic thrusting // FH epilepsy // female // crying after // only in public
52
what blood test can differentiate pseudoseizure from epilepsy
true eplipesy = raised prolcatin
53
DVLA ban following a one off seizure
6 months and reassess
54
DVLA ban following seizure when awake/ established epilepsy
seizure free for 12 months
55
DVLA ban following seizure when asleep
can drive if no awake attack for 3 years
56
DVLA ban following withdrawal AED
6 months after last dose
57
DVLA buses and lorries 1 off seizure
5 years
58
when can AEDs be considered to be stopped
seizure free 2 years, wean off over 2-3 months