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Epilepsy Qs Flashcards

1
Q

Cat 1

A

C PPP

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2
Q

2

A

CC
LO
RZ
SV T
Perampanel

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3
Q

Cat 3

A

BL
LE
GP
TV

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4
Q

How soon can suicidal behaviour occur with AED use?

A

1 week
report don’t stop

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5
Q

AHS

A
  • 8 weeks
  • Stop and report
  • Rash, fever, lymphadenopathy

Cat 1 and lamotrigine

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6
Q

Focal treatment

A
  1. LL
  2. COZ
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7
Q

Tonic clonic

A
  1. SV
  2. LL
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8
Q

Absence

A
  1. E
  2. SV
  3. LL
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9
Q

Myoclonic

A
  1. SV
  2. Leve
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10
Q

Atonic/tonic

A
  1. SV
  2. lamo
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11
Q

SE 1st line

A

COMMUNITY: Buccal midazolam/
PR diazepam
HOSPITAL: IV lorazepam

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12
Q

Topiramate: foetus

A

Cleft palate
Monitor foetal growth

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13
Q

What drugs are present in high amounts in breastmilk?

A

ZELP

primidone

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14
Q

What are febrile convulsions?

A
  • Seizures/ fits as a result of a fever/hyperthermia
  • Typically in ages 6 months to 3 years old
  • Lasts under 5 minutes (may take child 10-15 minutes to wake up after seizure)
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15
Q

Do febrile convulsions occurs due to hypo or hyperthermia?

A

Hyperthermia e.g. fever

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16
Q

What do you do if febrile convulsion lasts for more than 5 minutes or that there is no recovery in between febrile convulsions?

A

Treat as SE

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17
Q

Dravet’s syndrome treatment

Often confused as febrile convulsions occurs due to hyperthermia too

A
  1. SV
  2. Sodium valproate +
    Clobazam + Stiripentol
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18
Q

Lennox-Gastault syndrome treatment

A
  1. SV
  2. Lamotrigine mono or +
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19
Q

Drugs that reduce seizure threshoold

A

Quinolone
Mefloquine
SSRIs
Antipsychotics
TCA/related antidepressants

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20
Q

SV: CI

A
  • Acute porphyrias
  • Personal/ family history of severe hepatic dysfunction
21
Q

SV: monitor

A
  1. LFTs: before, every 6m
  2. FBC - vit D, Na
  3. Weight - BMI
22
Q

SV: SE

Remember VALPROATE

A

Vomiting
Alopecia
Liver tox
Pancreatitis
Retains fat (weight increase)
Oedema
Appetite increase
Tremor
Enzyme inhibitor

24
Q

SV: Interactions

A
  • Warfarin = increases anticoagulant effect
  • Lamotrigine = increase toxicity
  • Erythro/ cimetidine = increased SV
  • Inducers = decreased SV
25
Phenytoin sodium = phenytoin base
100mg = 92mg
26
Phenytoin: CI
- Acute porphyrias - Sino-atrial and heart block if given IV
27
Phenytoin: Range
10-20 mg/L OR 40-80 micromol/L
28
Phenytoin: Monitor
1. Cp 2. LFT 3. FBC (folate, vit D) 4. ECG + BP (IV)
29
Phenytoin: decreased protein binding
- Elderly/ children - Pregnancy - Liver failure
30
Phenytion: Toxicity
Slurred speech Nystagmus Ataxia Confusion Hyperglycaemia Diplopia
31
Phenytoin: SE
Paraesthesia Hirsutism Enlarged gums (GH) Neurotox = dizzy, ataxia Yellow Teratogenic Origin - HLAB allele Ideation - suicidal behaviours Nystagmus
32
Phenytoin decreases concentration of:
- CP - HRT - Wafarin - CS - Levo/lio
33
Carbamazepine: other indications
- AAW - Diabetic neuropathy - Trigeminal neuralgia - Bipolar
34
Carbamazepine: Monitoring
1. Cp 2. FBC 2. LFT 3. Renal
35
Carbamazepine: CI
Acute porphyrias * Hx of bone marrow depression
36
Carbamazepine: Range
4-12 mg/L OR 20-50 micromol/L
37
Carbamazepine: Toxicity | Remember IHANDBAG
IHANDBAG Incoordination Hyponatraemia Ataxia Nystagmus Drowsiness Blurred vision and diplopia (double vision) Arrhythmias GI disturbances
38
Carbamazepine: SE | Remember BASH
Blood disorder AHS Skin - HLAB allele Hepatic disorder
39
Carbamazepine + orlistat
Increased convulsions
40
Levetiracetam: SE
* Cold-like symptoms (e.g.nasopharyngitis, dizziness, drowsiness) * Anxiety and depression (low mood)
41
Lamotrigine: CI
* Parkinson's (may be exacerbated) * Myoclonic seizures (may be exacerbated)
42
Lamotrigine: Main SE
- SJS - Blood disorders
43
Phenobarbital: CI
* Acute P * History of drug/alcohol abuse * Resp dep
44
Ethosuximide: Main SE
Blood disorder
45
Topiramate: main SE
- Monitor foetal growth: cleft palate - Vision - Kidney stones (need adequate hydration to avoid)
46
Topiramate: Indication other
* Migraine proph
47
Vigabatrin; SE
Visual field effect
48
Zonisamide: SE
- weight loss - speech disorder
49

Qs (27 decks)

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