CV - HT Flashcards
At what K level would you add low dose spironolactone?
< 4.5
Which antihypertensive is preferred in breastfeeding?
Enalapril
Pregnancy - HT treatment
- Labetalol
- MR nifedipine
- Methyldopa
When should you stop methyldopa for HT in pregnancy?
- Stop at least 2 days after birth
- Risk of post-natal depression
Symptoms of pre-eclampsia
- Severe headache
- Pain below ribs
- Vision
- Vomiting
- Sudden swelling of face, hands, feet
What do we give for chronic HT in pregnancy
- Aspirin 75-150mg OD
- Week 12 to birth
ACEi: CI
- Bilateral renal artery stenosis/ aortic stenosis
- Pregnancy
- AKI
ACEi: SE
- COUGH
- Renal/ hep
- Angiodema
- Hyperkalaemia
ACEi: interactions
- ARBs
- K
- Lithium
- NSAIDs - renal
- Alcohol
ARBs: SE
- Hyperkalaemia
- Hypotension
- Renal
less cough and angiodema
CCB: RL
- Highly inotropic effects =
- Reduced myocontractility + HR
- Avoid in HF
Which antihypertensive should we avoid in HF?
RL CCB
CCB: dihydro SE
- oedema
- headache
- flushing
- constipation
CCB: interactions
- Statins: sim + amlo
- Dabigatran + verapamil
- BB + verapamil
- Carbamazepine
- Grapefruit juice
- Macrolides
Does diltiazem need to be prescribed by brand?
Only for dilt MR tabs with strength over 60mg
Does nifedipine need to be prescribed by brand?
For MR yes - no matter what strength
TLD: duration
act: 1-2 hrs
last: 12-24 hrs
TLD: CI
Hypokalaemia - risk of cardiac arrythmias
Which TLD has risk of non melanoma skin cancer with long term use?
Hydrochlorothiazide
TLD: SE
- Gout
- Hyperglycaemia
- HypoK, Na
- HyperCa
- Postural hypotension
TLD: interactions
- Lithium
- Digoxin
- NSAIDs
Loop: onset
1hr, diuresis complete within 6hrs
Can give BD if needed w/o interupting sleep
Loop: SE
- Gout
- Hyperglycaemia
- HypoK, Na, Ca
- Postural hypotension
- Oto
How to remember the electrolyte difference between TLD and loop
Only difference is Ca
TLD = high
Loop = low
Loop: interactions
- Lithium
- Digoxin
- NSAID
- AG - oto
