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CNS Qs Flashcards

1
Q

Pregabalin dose for neuropathic pain/ GAD

A

initially 150mg OD, MAX 600mg in 2-3 divided doses

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2
Q

Which antipsychotic is most likely to cause weight gain

A

Think 2nd gen cause metabolic syndromes
Clozapine and olanzapine

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3
Q

What metabolic side effects do 2nd gen antipsychotics have?

A
  • weight gain
  • raised BP
  • rasied BG
  • raised cholesterol
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4
Q

Gabapentin and opioids

A

Increased resp dep

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5
Q

deteriorated renal function, opioid in syringe driver

A

alfentanyl

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6
Q

What are the monitoring requirements for the use of methadone?

A

ECG monitoring recommended in those with INCREASED QT-PROLONGATION RISK FACTORS or >100mg DAILY

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7
Q

What schedule is methadone

A

2

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8
Q

Methadone SE

A
  • Mood changes
  • Exacerbation of asthma
  • Tiredness
  • Hyperprolactinaemia
  • QT interval prolongation
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9
Q

Which SSRIs are most associated with QT interval prolongation?

A
  • Citalopram, Escitalopram
  • Fluoxetine and sertraline = some evidence
  • Paroxetine and venlafaxine – not typically associated
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10
Q

Which antidepressants is the most likely cause of the patient’s abnormal menstrual cycle?

A

Fluoxetine

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11
Q

Symptoms of subarachnoid haemorrhage

A
  • thunderclap headache
  • stiff neck
  • blurred vision
  • nausea

Treated with nimodipine

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12
Q

what ingredient excipient in tegretol oral solution may be responsible for a patient experiencing bloating and gastro-intestinal side effects?

A

sorbitol

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13
Q

ACEi/ ARBs and surgery

A
  • severe hypotension after induction of anaesthesia
  • these drugs may need to be discontinued 24 hours before surgery
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14
Q

Which blood test must be normal before starting pt on clozapine?

A

Leucocyte and differential blood counts

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15
Q

Which drug can be detected using roadside screening device

A

Cannabis
Ketamine
Methadone
Morphine
Opiates

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16
Q

Levetiracetam + NSAIDs =

A

OK no significant interaction and do not affect seizure control

1.

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17
Q

SSRI toxicity

A

N+V, agitation, tremor, nystagmus, sinus tachy

18
Q

TCA toxicity

A

dry mouth, seizures, coma, arrythmias

19
Q

Fentanyl toxicity

A

resp dep, euphoria, reduced consciousness

20
Q

Aspirin toxicity

A

tinnitus, hyperventilagion, deafness

21
Q

SS symptoms

A

Confusion
Dizziness
Tachycardia
Tremor

22
Q

MIDRID

A

Paracetamol + isometheptene = acute attacks in migraines MIDRID

23
Q

Aripiprazole MHRA update

A

Increased risk of impulse control disorders

24
Q

TCA washout period

A

at least 1-2 weeks
3 weeks if its clomi/ imi

25
Q

SSRI washout period

A

Fluoxetine = 5 weeks
Sertraline = 2 weeks

26
Q

How long does Madopar capsules/tablets last once dispensed into another container before it expires? →

A

2 weeks

27
Q

Which drug is preferred in renal impairment? Codeine, Oxycodone or morphine

A

Oxycodone - similar properties to morphine, but preferred in renal impairment

28
Q

Clozapine and smoking

A

induces metabolism = significant increase in levels when smoking.

29
Q

Clozapine and stopping smoking

A

increased levels of clozapine

30
Q

Autonomic neuropathy symptoms

A
  • Excessive facial sweating
  • Postural hypotension
31
Q

Donepezil common SE

A

Aggression
No renal restrictions

32
Q

Which drug is effective for a pregnant woman with bipolar and epilepsy?

A

Lamotrigine

33
Q

Antipsychotic with the lowest risk of sexual dysfunction

A

Aripiprazole

34
Q

Treatment for overdose of diazepam

A

Flumanezil

35
Q

Which Parkison’d medication causes hepatotoxicity

A

Tolcapone

36
Q

Which antiemetic can cause oculogyric crisis?

involuntary upward deviation of both eyes

A

Metoclopramide
- Acute dystonic reaction

37
Q

What is the best method to switch from fluoxetine to paroxetine?

A

Stop fluoxetine; wait 4-7 days before starting paroxetine.

38
Q

Duloxetine + aspirin

A

Increased risk of bleeding

39
Q

Pt on lithium with dry skin and brittle nails - what should we monitor?

A
  • Hypothyroidism symptoms
  • Long term use = thyroid disorder
  • Monitor thyroid function
40
Q
A

Qs (27 decks)

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