Epilepsy Flashcards

1
Q

Epilepsy

Name 4 types of generalised seizures.

A
  • tonic-clonic
  • myoclonic
  • absence
  • tonic, clonic, atonic seizures
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2
Q

Epilepsy

Name 3 types of focal seizures.

A
  • aura
  • motor
  • loss of awareness or responsiveness
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3
Q

Epilepsy

What is a generalised seizure?

A

simultaneous involvement of both hemispheres
- consciousness is always lost

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4
Q

Epilepsy

What is a focal seizure?

A

electrical discharge restricted to a limited part of the cortex of one cerebral hemisphere
- consciousness may be lost of maintained

further characterisable features
- aura
- motor
- change in awareness/consciousness

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5
Q

Epilepsy

Focal seizures with electrical activity confined to one part of the brain may spread after a few seconds, due to failure of inhibitory mechanisms, to involve the whole of both hemispheres, causing a ____

A

bilateral tonic–clonicseizure

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6
Q

Epilepsy

What is seen in an EEG every time a pt has an absence seizure?

A

3Hz spike-and-wave EEG activity

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7
Q

Epilepsy

How does an absence seizure appear to an observer?

A

loss of awareness and a vacant expression for less than 10 seconds before returning abruptly to normal and continuing as though nothing had happened

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8
Q

Epilepsy

What are the 3 phases of a Generalized tonic–clonic seizures.

Describe each stage

A

prodrome
- aura may or may not be present due to speed of onset of seizure
tonic clonic
- body stiffens
- synchronous jerking of the limbs
- eyes open / tongue bitten / incontinence
post-ictal phase
- flaccid body
- consciousness returns
- confusion/drowsiness and headache often present after

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9
Q

Epilepsy

____ seizures or ‘jerks’ take the form of momentary brief contractions of a muscle or muscle groups: for example, causing a sudden involuntary twitch of a finger or hand. They are common in primary generalized epilepsies.

A

myoclonic

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10
Q

Epilepsy

____ seizures consist of stiffening of the body, not followed by jerking.

A

Tonic

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11
Q

Epilepsy

____ seizures involve a sudden collapse with loss of muscle tone and consciousness.

A

Atonic

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12
Q

Epilepsy

What type of seizure does this describe?
These originate within the motor cortex. Jerking typically begins on one side of the mouth or in one hand, sometimes spreading to involve the entire side. This visible spread of activity is called the Jacksonian march of a seizure. Local temporary paralysis of the limbs affected sometimes follows: Todd’s paralysis.

A

focal motor seizures

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13
Q

Epilepsy

What type of seizure does this describe?

These usually arise from the temporal lobe (60%) or the frontal lobe. There is often a preceding aura followed by a period of complete or partial loss of awareness of surroundings, lasting for 1–2 minutes on average (as opposed to 10seconds in absence seizures), which the patient generally does not remember subsequently. This stage is accompanied by speech arrest and often by automatisms : semi-purposeful stereotyped motions such as lip smacking or dystonic limb posturing, or more complex motor behaviours such as walking in a circle or undressing. The attacks may be followed by a short period of post-ictal confusion or may develop into a bilateral tonic–clonic seizure.

A

Focal seizures with altered awareness or responsiveness

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14
Q

Epilepsy

The range of causes of epilepsy is different at different ages and in different countries.
* Children and teenagers : ____
* Younger adults : ____
* Older ages (>60years) : ____

A
  • Children and teenagers : genetic, perinatal and congenital disorders predominate.
  • Younger adults : trauma, drugs and alcohol are common.
  • Older ages (>60years) : vascular disease and mass lesions such as neoplasms are important.
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15
Q

Epilepsy

Name 3 types of primary generalized epilepsies

A
  • childhood absence epilepsy
  • juvenile myoclonic epilepsy
  • monogenic disorders
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16
Q

Epilepsy

What examples of infections may cause a seizure?

A
  • encephalitis
  • cerebral abscess
  • tuberculomas
  • chronic meningitis
17
Q

Epilepsy

What metabolic abnormalities could cause a
seizure?

A
  • hypocalcaemia, hypoglycaemia, hyponatraemia
  • acute hypoxia
  • uraemia, hepatic encephalopathy
  • porphyria
18
Q

Epilepsy

What kind of drugs may caused a seizure?

A
  • psychiatric drugs
  • cocaine
19
Q

Epilepsy

What investigations are carried out following an episode of loss of consciousness?

A

Blood tests (serum calcium)
ECG

20
Q

Epilepsy

How to take a history of a seizure:

A

Witness account is crucial.
* What happened:
– Before: aura versus pre-syncopal prodrome
– During: convulsion, automatisms versus brief syncopal blackout and pallor
– After: post-ictal confusion and headache versus rapid
recovery in syncope
* Circumstances:
– Seizure triggers? Sleep deprivation, alcohol binge or drugs
– Syncope triggers? Pain, heat, prolonged standing

* Epilepsy risk factors?
– Childhood febrile convulsions
– Significant head injury
– Meningitis or encephalitis
– Family history of epilepsy

* Previous unrecognized seizures?
– Myoclonic jerks
– Absences
– Auras (focal seizures)

* Alcohol excess?
* Medication lowering seizure threshold?
* Hold a driving licence?

21
Q

Epilepsy

What counts as a prolonged seizure?

A

> 5mins

22
Q

Epilepsy

How do we terminate a seizure in an emergency?

A

rectal diazepam, intravenous lorazepam or buccal midazolam

23
Q

Epilepsy

How do we manage the post-ictal phase (after emergency management)?

A

Oxygen should be given and the airway monitored

24
Q

Epilepsy

What do we call this:
a medical emergency where there are continuous seizures for 30 minutes or longer

A

status epilepticus

25
Q

Epilepsy

How do we manage status epilepticus in an early status (<30mins)?

A
  • O2
  • monitor ECG + bp
  • routine bloods
  • lorazepam i.v. 4mg bolus
26
Q

Epilepsy

What are some first-line treatments for generalised tonic-clonic seizures?

3

A

Sodium valproate
Levetiracetam
Lamotrigine

27
Q

Epilepsy

What are some first-line treatments for focal seizures withough secondary generalisation?

A

Carbamazepine
Lamotrigine
Levetiracetam

28
Q

Epilepsy

What are some first-line treatments for myoclonic seizures?

A

Sodium valproate
Levetiracetam
Topiramate

29
Q

Epilepsy

What medication might make a myoclonic seizure worse?

A

Carbamazepine

30
Q

Epilepsy

What are some generalise principles to AED prescribing?

A
  • start at low dose and titrate up slowly
  • aim for mono-therapy
31
Q

Epilepsy

What are some common SE of AEDs?

A

unsteadiness
nystagmus
drowsiness
skin rashes

32
Q

Epilepsy

Baseline blood investigations include:

A
  • FBC
  • U&Es
  • LFTs
  • Calcium profile
  • Glucose level – assessing for any acute infective or biochemical causes of seizures.
33
Q

Epilepsy

Status epilepticus:

If no IV access has been established, then immediate treatment is ____.

A

rectal diazepam

34
Q

Epilepsy

Status epilepticus:

If IV access has been established, then immediate treatment is ____.

A

IV lorazepam

35
Q

Epilepsy

Status epilepticus

If seizures remain ongoing despite the administration of two doses of lorazepam, then the algorithm progresses to more specialised drugs such as ____ .

A

phenytoin, phenobarbital or levetiracetam

36
Q

Epilepsy

What is SUDEP?

A

sudden unexplained death in epilepsy

It is rare, but pt need to be councelled about it.

37
Q

Epilepsy

What medication is considered first-line for women of child-bearing age of all seizure types?

Why?

A

Lamotrigine

  • it is the least teratogenic of the commonly-used anti-epileptic drugs
38
Q

Epilepsy

What are some common triggers for seizures?

A
  • alcohol
  • drugs
  • sleep deprivation
  • non-compliance with medication
  • stress