enzyme inhibition w/german (9/15)

Question 1

competitive inhibition

Answer 1

-directly compete with substrate at the the same binding site.

Km moves right, no change to Vmax

Question 2

uncompetitive inhibition

Answer 2

inhibitor binds the ES complex but not the enzyme alone.
inhibitor binds at a separate binding site rendering enzyme nonfunctional.

Reduces the concentration of functional enzyme

lowers Vmax, moves Km left

Question 3

noncompetitive inhibition

Answer 3

inhibitor binds the enzyme or ES complex
slows or stops enzymatic process, substrate binding not affected

Reduces Vmax, no change in Km

Question 4

mixed inhibition

Answer 4

• inhibitor binds enzyme alone or ES complex.
• affects substrate binding and enzyme function.

reduces Vmax, Km moves right