Enterohemorrpagic Escheristia coli

Question 1

transmission route

Answer 1

comsumption of products from animals colonized with EHEC (eg E coli O157:H7)
also from hamburger, unpasteurized juice and fresh vegetables

Question 2

diseases it cause

Answer 2

bloody diarrhea and hemolytic uremic syndrome

Question 3

what toxin does it have

Answer 3

shiga toxin

Question 4

pathogenesis

Answer 4

1. ingestion of Shiga toxin-producing E coli
2. Shiga toxin cause mucosal injury of intestinal cells, which results in bloody diarrhea and abdominal pain
3. toxin translocate from gut to circulation, then to kidney
4. at kidney, microvasculature–> thrombocytopenia (low blood platelet, hemolysis, renal failure, hemolysis)–>HUS

Question 5

treatment

Answer 5

supportive (severe diarrhea +/- blood transfusion)