Enterobacteriacae Flashcards
What is the major cell wall antigen in Enterobacteriacae
LPS - lipopolysaccharide
What are the three major components in the LPS?
Outer somatic polysaccharide, Core polysaccharide, and Lipid A
What is the common antigen that all Enterobacteriacae possess?
Core polysaccharide (in LPS)
What part of LPS is important for epidemiologic classification of strains within a species?
O polysaccharide
What is the function of Lipid A?
Endotoxin - virulence factor
The serologic classification of Enterobacteriacae are based on what three major antigens?
Somatic O polyssaccharides, K (capsule) antigens, and H (flagellar) antigens
What diseases (two main ones) does E.coli O:157 H:7 cause?
Hemorrhagic colitis and hemolytic uremic syndrome (HUS)
What are the two toxins that ETEC possesses that cause watery diarrhea?
STa and LT-I (heat stable toxin and heat labile toxin)
What is the pathogenesis of EPEC?
Attachment/Effacentment (A/E) – Attachment to intestinal epi cells and destruction of microvilli
EPEC causes what symptoms and primary affects what age of people?
Watery diarrhea; infants
What is the cluster of genes called that causes virulence in EPEC and STEC?
locus of enterocyte effacement (LEE)
What ECOL? Most infections are attributed to the consumption of undercooked ground beef or other meat products, water, unpasteurized milk or fruit juices (e.g., cider made from apples contaminated with feces from cattle), uncooked vegetables such as spinach, and fruits.
STEC
VTEC and EHEC are subgroups of what type of ECOL
STEC
The diagnosis of STEC is made based on the production of what two toxins?
Stx1 and Stx2
What type of ECOL can cause hemorrhagic colitis and hemolytic uremic syndrome?
STEC