ENT Pathology 2 Flashcards
4 sx associated w/herpetic stomatitis (cold sore)
- lymphadenopathy
- fever
- anorexia
- irritability
Recurrent herpetic stomatitis (in contrast to acute herpetic gingivostomatitis) occurs at the __________________.
site of primary inoculation or in adjacent mucosa associated with the same ganglion
Dx? Why?
laryngeal carcinoma
extends from the larynx to epiglottis (some errosion)
laryngeal carcinoma sx
- cough
- hoarseness
- dysphagia
(advanced lesions can ulcerate –> hemoptysis)
laryngeal carcinoma: progression of cellular change
epithelial hyperplasia –> epithelial dysplasia
Dx? Why?
- laryngeal carcinoma
- R vocal cord mass invading hyoid bone
(best prognosis if it remains intrinsic i.e. not invading outside larynx)
Dx? Why?
- laryngeal carcinoma (squamous cell)
- metaplastic squamous epithelium (left), squamous cell carcinoma w/ulceration (right)
- keratin pearls
Dx? Why?
- laryngeal papilloma
- projections of benign squamous epithelium covering fibrovasculra core
prognosis (adults & children)
solitary in adults
recurrence in children after resection
causative organism
Human papilloma 6 & 7
(non-cancerous)
Dx? Why?
- cholesteatoma
- cholesterol clefts, fibrinous center, debris and RBCs
carcinoma of the larynx is typically which type of CA?
squamous cell
(smokers, drinkers, males)
oropharyngeal CA is most often caused by what?
(50%)
HPV
95% or head & neck cancer is caused by which type of cancer?
squamous cell
squamous cell carcinoma is commonly caused by mutation of which tumor suppressors? Amplification of which genes?
- p16 & p53
- Cyclin D1
Dx? Why?
- leukoplakia
- cellular dysplasia (nuclear & cellular pleomorphisms), mitotic figures
