Endometrial Hyperplasia/Carcinoma Flashcards
Endometrial hyperplasia and carcinoma often__
coexist.
The majority of the cases occur secondary to ___
chronic exposure of the endometrium to unopposed
estrogen.
cxfx
abnormal uterine bleeding or postmenopausal bleeding.
Adipose tissue has ___which converts ___to ___ and is responsible for increased risk of ___.
aromatase
androgens
estrogens
endometrial hyperplasia in obese women
obese women are less likely to experience:
menopausal symptoms
Endometrial hyperplasia is classified into 2 categories
Hyperplasia without atypia (benign): Atypical hyperplasia (endometrial intraepithelial neoplasm)
Hyperplasia without atypia (benign): proliferative endometrium with
____ glands
dilated and contorted
Atypical hyperplasia (endometrial intraepithelial neoplasm): epithelial crowding with increased ___ ratio and cells appearing ___ from normal endometrial cells
gland to stroma
distinct
Risk Factors
Obese, postmenopausal woman PCOS Tamoxifen therapy Early menarche Late menopause Lynch syndrome
Management ranges from
surveillance, progestin therapy, or hysterectomy.
The risk of progression to endometrial carcinoma
among patients with benign endometrial hyperplasia (without atypia)___%.
5
Atypical hyperplasia has a high risk of progression to ____and a potential for ____, making ___the treatment of choice.
endometrial carcinoma
existing invasive disease
hysterectomy
