Endometrial Cancer

Question 1

Endometrial cancer is a

Answer 1

Hyper Estrogenic state
Excessive Estrogen and excessively ovulation

Question 2

Risk factors of endometrial cancer

Answer 2

Family history
Hypertension
Obesity
Atypical uterine bleed
Unopposed oestrogen in pcos
Nulliparity
Tamoxifen theraphy

Question 3

Why is tamoxifen therapy is considered as a risk factor for endometrial cancer

Answer 3

Selective Estrogen receptor modulator
Antagonist effect on the Breast
Agonist effect on the endometrium

Question 4

Estrogen alone leads to

Answer 4

Endometrial cancer

Question 5

Estrogen and progesterone leads to

Answer 5

Breast cancer

Question 6

Corpus cancer syndrome

Answer 6

Increased chance of cancer in the obese
Diabetic
Hypertension patients

Question 7

Which is better tamoxifen or raloxifen

Answer 7

Raloxifen as there are no side effects like endometrial cancer and Genitourinary symptoms

Question 8

What is the familial inheritance involved in the endometrial cancer

Answer 8

Lynch syndrome2
60-70 percent increased

Brca 1 and BRCa 2

Cowdensyndrome pten gene

Lynch»»>cowden

Question 9

Genes involved in the lynch syndrome

Answer 9

Mlh1
Msh2

Question 10

Most common cancer involved in the lynch syndrome is

Answer 10

Colorectal cancer then
Endometrial cancer 2 commo

Question 11

Protection against endometrial cancer

Answer 11

Physical exercise
Smoking
Multiparity
Pregnancy
Ocps
Breast feeding

Question 12

Classification of endometrial cancer

Answer 12

Types
Histopathogical
Grade

Question 13

Gatekeeper of endometrial cancer

Answer 13

Cowden

Question 14

What are the histological varieties of endometrial cancer a

Answer 14

Adenocarcinoma most common
Clear cell variety
Serous variety
Papillary serous variety

Question 15

Grades

Answer 15

1. Well
   2 moderate
   3 poor differentiated

Question 16

Most malignant histological variety is

Answer 16

Clear cell type >serous papillary

Question 17

Explain type 1 tumour

Answer 17

Adenocarcinoma grade1 and grade 2

Increased Estrogen
Pten Kara’s gene mutations
Good prognosis
Obese female and endometrial hyperplasia
Seen in comparatively 50-70

Question 18

Type 2 endometrial cancer

Answer 18

Adenocarcinoma grade 3
Clear cell carcinoma and papillary serous tumours

Not related to Estrogen
Not associated with the genes
Thin females
P53 mutation
Bad
65-70 yrs

Question 19

Type1 associated with

Answer 19

Cowden
Lynch
Hnpcc

Question 20

Most common age

Answer 20

60 yrs

Question 21

Most comm symptoms for endometrial cancer

Answer 21

Is irregu bleeding >post menopausal bleeding

Question 22

Indications of endometrial biopsy

Answer 22

Post menopausal bleeding with thickness>4mm
Aub patient with >45 yrs
Reproductive age with thickness >12mm

Question 23

Indications for fractional currentage after endometrial biopsy

Answer 23

Inadequate sample
Hyperplasia with atypia
Normal but patient continues to bleed
Cervical stenosis

Question 24

Other investigations in the endometrial cancer

Answer 24

Pap smear post coital bleeding

Ct lymph nodes metastasis

MRI done to know whether the lower uterine segment , myometrium cervix is involved

Question 25

Most common route of spreading

Answer 25

Direct spread

Question 26

Most common hematogenous spread is

Answer 26

Lungs

Question 27

How to differentiate serous variety from ovarian cancer

Answer 27

Ca125 levels raised
Peritoneal spread is there