Endocrinology - Patient Management Flashcards
what are the clinical signs of feline hyperthyroidism?
Polyphagia, weight loss, tachycardia, palpable enlarged thyroid gland
what medical treatment can be done for feline hyperthyroidism?
anti-thyroid drugs
how can diet treat feline hyperthyroidism?
iodine restricted diet
what surgery can be done to treat feline hyperthyroidism?
thyroidectomy
what other curative method of treatment can be done for feline hyperthyroidism?
radioactive iodine
what does medical management do in terms of giving drugs?
they bloxk synthesis of thyroid hormones, more T4 is produced if an adenoma continues to grow
what are examples of drugs that can treat feline hyperthyroidism?
methimazole or carbimazole
when will a cat with hyperthyroidism be euthyroid after being given medical management?
2-3 weeks
what are the common side effects of anti-thyroid drugs?
- Vomiting, anorexia, lethargy
- Usually minor and transient * 10-20% of cats
what are the rare side effects of anti-thyroid drugs?
- Persistent GI signs
- Bone marrow suppression
- Facial pruritis
- Hepatopathy
- Rare (1-5% of cats) but serious- stop treatment
what are the nursing considerations for feline hyperthyroidism?
- Careful handling
- Often fractious!
- Concurrent disease- cardiac disease, arthritis
- Gabapentin?
- Senior cat clinics- look out for clinical signs of hyperthyroidism as common
in older cats - Often T4 measurement included in senior cat bloods
what treatment monitoring can you do for feline hyperthyroidism?
- Treatment monitoring- often dose increases required over time
- Recurrence, concurrent disease (CKD particularly)
- Every 3-12 months
- Clinical signs
- Blood tests- T4, haem, biochem
- Urine and BP
what dietary management can be done for feline hyperthyroidism?
- iodine restricted
- must be only food they eat for rest of their life
- less effective than other options
what are the disadvantages of feline hyperthyroid diet management?
- Not suitable if severely hyperthyroid
- Not suitable if other dietary requirements- IBD, CKD
- Not suitable for euthyroid cats in household
what is canine hypothyroidism?
- Destruction of thyroid tissue
what are the clinical signs of canine hypothyroidism?
- Weight gain, lethargy, bradycardia, endocrine alopecia, myxoedema
coma
what are the nursing considerations for canine hypothyroidism?
- weight management clinics
- treatment monitoring
- T4 bloods 6-8weeks after starting treatment
- 6-12 months reviews
what is calcium necessary for?
- Muscle contraction and nerve conduction
where is calcium found?
- Mostly stored in bones (with phosphate)
- Found in three forms in blood:
- Ionised- free, biologically active
- Complexed- inactive
- Protein-bound- inactive
what are the hormones of calcium balance?
parathyroid hormone
calcitriol (vitamin D)
calcitonin
what is primary hyperthyroidism?
- One or more parathyroid glands become hyperfunctional and secrete
excess PTH - Usually due to solitary benign tumour
what are the neurological signs of primary hyperparaythyroidism?
weakness, lethargy, exercise intoleracne and trembling
What are the gastrointestinal signs of primary hyperparathyroidism?
reduced appetite, nausea, vomiting and constipation
what are the urinary signs of primary hyperparathyroidism?
PUPD, urolithiasis, UTI
what are the cardiovascular signs of primary hyperparathyroidism?
hypertension and arrythmias
how is primary hyperparathyroidism diagnosed?
- elevated calium often accidental
- blood gas or extenal lab testing
- measure PTH is elevated ionised calcium
how do you treat primary hyperparathyroidism?
surgery
- ultrasound guided glandular ablation by heat or ethanol injection
what is secondary hyperparathyroidism?
chronically low calium leads to eleveated parathyroid hormone leading to renal failure
what are the nutritional causes of secondary hyperparathyroidism?
- dogs and cats fed diet with little or no calium or deficicne tin vitamin D
- high PTH causes calium to be metabolised from bone
- home-made diets can cause this