Endocrinology Flashcards

1
Q

diagnostic criteria for metabolic syndrome

A

Any 3 or the following:

  1. Abdominal obesity:
    waist>40inches (male)
    waist>35 (female)
  2. TG>150 mg/dL
  3. HDL130/85 mmHg
  4. FSG> 100mg/dL (or 2hr post oral glucose>140mg/dL)

associated with stroke, other CV complications

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2
Q

diagnostic criteria for DM2

A

FSG>126
Random serum glucose 200
OGTT>200
HbA1C>6.5%

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3
Q

Metformin

A

decreases hepatic gluconeogenesis
no weight gain
no hypoglycemia

adverse effects:
GI disturbances
decreased B12 absorption
lactic acidosis (metabolized by kidney, and builds up with inadequate kidney function, heart failure etc would increase the changes of this happening)

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4
Q

how much do DM meds drop the A1C reading?

A

1-2% on average, per drug
more obvious effect if it starts higher

this might be a reason to start multiple drugs (one at a time)

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5
Q

sulfonylureas

glimepiride
glipizide
glyburide

A

stimulate insulin release from beta cells by activating potassium-ATP channel

caveat- requires functional pancreas, and puts patient at risk of hypoglycemia

use with caution in patients who have hepatic or renal insufficiency, can cause some weight gain

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6
Q

thiazolidinediones (TZD)
rosiglitazone
pioglitazone

A

decrease hepatic gluconeogenesis, increase insulin sensitivity

adverse effects: weight gain, fluid retention
pulmonary edema
CHF exacerbation
peripheral edema

use with caution in patients who have liver dysfunction

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7
Q

DPP-4 inhibitors

sitagliptin
saxagliptin
linagliptin
alogliptin

A

These drugs inhibit enzyme DPP-4.
The DPP-4 enzyme metabolizes GLP-1 (glucagon like peptide 1)

Endogenous GLP-1 decreases glucagon secretion, increases insulin secretion, and also delays gastric emptying

Not super effective (0.5% decrease in A1C), but advantage is that they don’t cause a lot of side effects, no hypoglycemia, no weightgain, and not many contraindications

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8
Q

GLP1 receptor agonists (incretin mimetics)

exenetide
liragletide
dulaglitide

A

Decrease glucagon secretion
Increase glucose- dependent insulin secretion
Delay gastric emptying

Exenatide- analog of exendin (Gila monster saliva), with similar effects to GLP-1

Liraglutide and dulaglutide are similar in effect, if not stronger, and are synthetic analogs of human GLP1

These are active peptides and must be injected

Adverse effect: nausea (slowed gastric effect), weightloss

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9
Q

SGLT-2 inhibitors

dapagliflozin
canagliflozin
empagliflozin

A

SGLT-2 transporters are found in the kidney, and they help with glucose reabsorption in the tubules.

These medications augment the inhibition of SGLT 2 receptors so that more glucose gets lost in the urine instead of being reabsorbed

similar effect to metformin
caveat- relies on functional kidneys

recurrent urinary tract infections and major mycotic infections

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10
Q

alpha- glucosidase inhibitor

acarbose

A

alpha-glucosidase enzyme is in the brush border of the intestines and breaks down complex carbohydrates into glucose so they can be absorbed

adverse effects:

  • diarrhea
  • flatulence
  • abcominal cramping

acarbose- reactive hypoglycemia following gastric bypass surgery

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11
Q

Pramlintide

Amylin analog

A

Amylin hormone is released with insulin in response to food, and this is unique because it is the only non-insulin drug approved for type 1

injected TID

not popular

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12
Q

Meglitinides

nateglinide
rapaglinide

A

similar effect as sulfonylureas, but with shorter active time

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13
Q

lactic acidosis is a rare but worrisome side effect

A

metformin

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14
Q

most common side effect is hypoglycemia

A

sulfonylureas, meglitinides

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15
Q

oldest and cheapest of the oral agents

A

metformin, sulfonylureas (40years)

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16
Q

often used in combination with any of the other oral agents, first-line for 2DM

A

metformin

17
Q

also helps lower TG and LDL cholesterol

A

metformin

18
Q

not safe in settings of CHF

A

TZDs

19
Q

should not be used in patients with elevated serum creatinine, or renal dysfunction

A

metformin, SGLT2 inhibitors

20
Q

should not be used in patients with IBD

A

alpha- glucosideas inhibitors, GLP1 agonists, metformin

21
Q

hepatic serum transaminase levels should be carefully monitored when using these agents

A

metformin, TZDs

22
Q

not associated with weight gain, often used in overweight diabetic patients

A

metformin, DPP-2 inhibitors, GLP1 agonists, SGLT 2

23
Q

metabolized by liver, acceptable choice in patients with mild to moderate renal disease

A

TZDs, DPP4 inhibitors

24
Q

Hyperthyroid and palpation of single thyriod nodule

A

toxic thyroid adenoma

25
Q

hyperthyroid and palpation of multiple thyroid nodules

A

multinodular goiter

26
Q

hyperthyroid and recent study using IV contrast (iodine) in someone who was previously didn’t have enough iodine

A

Jod-Basedown phenomenon

27
Q

hyperthyroid and recent eye changes including proprosis, edema, injection

A

Graves disease

28
Q

History of thyroidectomy or radioablation of thyroid with hyperthyroid

A

excess thyroid hormone replacement