Endocrine System and Reproductive histology Flashcards

1
Q

Hypothalamus

A

Main autonomic control center for the body, homeostasis
Regulates temp, food intake, water, sleep, behavior, endocrine
9 hormones
5 releasing hormones for anterior pituitary
2 inhibiting hormones for anterior pituitary
2 shipped and released by anterior pituitary

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2
Q

Pituitary gland

A

Hypophysis
Attached to hypothalamus via infundibulum
Sit on sella tunica of sphenoid bone or hypophyseal fossa
2 functional components
Anterior lobe: pars distalis, pars intermedia, pars tuberalis
Posterior lobe: pars NERVOSA and infundibulum

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3
Q

Pars distalis

A

Cords of epithelial cells interspersed with fenestrated capillaries

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4
Q

Pars intermedia

A

Basophilic cells produce MSH, melanocytes stimulating hormone
Surrounds a series of collided filled follicles that are residual lumen from Rathkes pouch

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5
Q

Pars tuberalis

A

Forms collar around infundibulum and has cells with basophils gonadotropic cells

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6
Q

Pars NERVOSA

A

Neurosecretory axons and their endings
Transport hormones from hypothalamus to posterior pituitary
HYPOTHALAMO-HYPOPHSYEAL TRACT
Fibroblasts, mast cells, and pituicytes (glial cell like astrocytes most abundant)
Hormones: OXYTOCIN AND ANTIDIURETIC HORMONE (vasopressin)
Hormones are stored in vesicles in dilated portions of axons near terminals HERRING BODIES, neurosecretory bodies
Herring bodies end in terminal buttons

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7
Q

Infundibulum

A

Bundle of axon from the hypothalamus

Contains neuroses retort axons forming the HYPOTHALAMO-HYPOPHSYEAL TRACT

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8
Q

Anterior pituitary hormones

A

Work in a negative feedback loop with the hypothalamus via the hypothalamo hypophyseal portal system
1. Chromophils- 50% of pars distalis hormones stored in cytoplasmic granules
A. Basophils 10%
B. Aciophils 40%
2. Chromophobes - 50% almost no granules so they are undifferentiated reserve cells

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9
Q

Hypothalamus hormones transport

A

Neurosectretory neurons send hormones
Travel into the hypophyseal portal system at primary plexus of the hypophyseal portal system (fenestrated capillaries)
Travel via the hypophyseal portal veins into the secondary plexus of the hypophyseal portal system
Bringing the hormones to the cells of the pars distalis

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10
Q

Anterior pituitary chromophil

A

HGH- somatotropes, acidophil
TSH- thyrotropes, basophils
FSH- gonadotropes, basophils
LH- gonadotropes, basophils
Prolactin PRL- lactotropes, acidophil
Adrenocortictrophic hormone ACTH- corticotropes, basophils
Melanocytes stimulating MSH- corticotropes, basophils

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11
Q

Anterior pituitary hormone function

A

HGH- IGF insulin like growth factor, growth
TSH- secretion of thyroid hormones
FSH- iniates oocyte development and ovarian secretion of estrogen. In males testes produce sperm
LH- stimulates estrogen, progesterone, ovulation, formation of corpus luteum. In males stimulates testosterone production
PRL- promotes milk
ACTH- gluccorticoids secretion
MSH- Unknown role but darkens skin

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12
Q

Posterior pituitary hormone function

A

Oxytocin OT- released in response to uterine distention, stimulates smooth muscles of uterus and mammary glands
ADH or vasopressin- released in response to high blood pressure, dehydration, loss of blood….conserves body water and decrease urine

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13
Q

Pineal gland

A
Hormone is melatonin, in Diencephalon 
Responsible for sleep cycle
2 cells
Pinealocytes or parenchymal cells - 95%
Interstitial cells- 5%

Characteristic presence of corpora arenacea or brain sand

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14
Q

Adrenal glands

A

Capsule around the gland
1. Cortex- large peripheral area 80% of gland, steroids

  1. Medulla- smaller area centrally located, catecholamine cells
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15
Q

Adrenal cortex

A

Zona glomerulosa- mineralcorticoids =aldosterone
Zona fasiculata- steroids, cortisol =glucocorticoid
Zona reticularis- androgens= gonadocorticoids

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16
Q

Adrenal medulla

A

Highly vascularized
Chromaffin cells
Epinephrine and norepinephrine = catecholamines
Small amount of dopamine
Receives preganglionic sympathetic axons straight to chromatic cells
-synapse directly on cells (different from every other)

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17
Q

Adrenal gland hormone function

A

Aldosterone- regulates water and ions for low blood pressure situations
Cortisol- regulates metabolism, suppresses immune, resistance to stress
Androgen- DHEA, early pubic growth
Catecholamines- intensify sympathetic response

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18
Q

Pancreas

A

Islets of langerhans
Beta cells- insulin
Alpha cells- glucagon
delta cells - somatostatin, or Growth hormone inhibiting hormone

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19
Q

Thyroid gland

A

Thyroid follicles surrounded by follicular cells (produce thyroglobulin or TGB)
T4- thyroxine
T3- Tri iodothyronine
Important in growth, cell differentiation, and metabolic rate
So increase oxygen consumption if metabolic increases
Make thyroglobulin as inactive form in the follicles
Parafollicular- C cells are large pale staining that produce calcitonin
CALCITONIN- decreases circulating calcium, increase osteoblasts

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20
Q

Parathyroid gland

A

2 cell types
Chief cells or principal cells- produce parathyroid hormone, small round cells central nucleus, larger amount
Oxyphil cells- larger cells very acidophilus, unknown function

PTH- increase calcium levels in the blood, increase ostesclasts

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21
Q

Components of male reproductive system

A

Testes
Passageways- straight tubules, rete testis, epidymis, vas deferens, ejectulatory duct, urethra, penis
-SREVEN UP
Accessory glands- seminal vesicles, prostate gland, bulbourethral gland
Penis

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22
Q

Testes function

A

Endocrine with testosterone
Exocrine with sperm or spermatogenesis
1. Spermatogonial phase- undergo mitosis to make spematocytes
2. Spermatocyte phase-undergo meiosis 1-2
3. Spermatid phase- maturation, tail and body formation

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23
Q

Seminiferous tubules

A
Lined with complex stratified epithelium
Area is lined with sperm or sperm cells that are waiting maturation
1. Sertoli cells or supporting cells
2. Spermatogenesis cells
- spermatogonia- 3 types
-primary spermatocytes
-secondary spermatocytes
- spermatids
24
Q

Testes layers

A
Tunica vaginalis
Tunica albuginea
Septums
Seminiferous tubules
Straight tubules
Mediastinum testes
RETE testis
25
Straight tubules
Lined with only Sertoli cells Open into RETE testis Cuboidal epithelium with under lying DCT
26
Rete testis
Network of channels Lined with cuboidal epithelium with DCT Single apical cilium and few Microvilli
27
Efferent ductules
Leads to head of epidymis Lined with psuedostratified columnar epithelium, cilia With groups of nonciliated cuboidal cells with Microvilli Some smooth muscle
28
Epidymis
``` Highly coiled tube Pseudo stratified columnar epithelium -rounded basal cells - columnar cells with Stereocilia or principal cells Smooth muscle surrounds 4-5 meters Maturation of sperm occurs ```
29
Vas deferens
Psuedostratified columnar epithelium with sparse Stereocilia 3 layers of smooth muscle, longitudinal circular longitudinal Ampulla- dilated area where epithelium is thicker and folded Ejectulatory duct- ductus deferens in prostate gland after seminal vesicles join, no muscular layers
30
Urethra
Prostatic- transitional epithelium Membranous- stratified columnar or pseuodo Spongy or penile- psuedostratified or stratified squamous
31
Accessory glands
Seminal vesicles Prostate glands Bulbourethral glands
32
Seminal vesicles
``` Simple columnar epithelium or pseudo Rich in secretory granules Joins with ampulla to make ejactulatory duct Folds in lumen increase surface area 2 smooth muscle layers Make 60% of fluid which is sugar based ```
33
Prostate gland
30-50 tubuloaveolar glands in a muscular fiber stroma Empties into prosthetic urethral Contains prostatic concretions- deposited gags and glycoproteins Fluid will activate sperm Simple or pseudo stratified columnar epithelium
34
Bulbourethral glands
Cowper's glands Compound tubuloaveolar glands Mucous secreting simple columnar epithelium Empty into proximal penile urethra
35
Penis
Paired corpora cavernosa Single corpus spongiosum Lined with psuedostratified columnar Surrounded with DCT or the tunica albuginea
36
Endocrine
Estrogen : growth | Progesterone : prepares the uterus for pregnancy and mammary glands for milk
37
Exocrine
Produce ovum
38
Ovary layers
Germinal epithelium Tunica albuginea Cortex- ovarian Medulla- blood vessels and nerves
39
Primordial germ cells
First month of fetal development migrate to gonadal ridge Divide via mitosis
40
Oogonia
Proliferate via mitosis Undergo meiosis at third month Enter prophase of meiosis one, stop Arrested cells are primary pockets
41
Primary oocytes
Surrounded by flattened cell called follicular cell Creates primordial follicle
42
3 types of follicles
``` Primordial follicles Growing follicles - primary follicle: unilaminar or multilaminar -secondary follicle Mature or Graafian follicles -will ovulate secondary oocytes ```
43
Granulosa cells
Make up the stratum granulosum Stratified epithelium around a Late or Multilayered primary follicle Zone Pollucida forms at this point
44
Theca folliculi
Is a sheath of connective tissue from strongly cells Theca interna: secrete estrogen Theca external: smooth muscle exterior Both of these sit a top the basal lamina which is atop the follicular cells
45
Secondary follicle
Follicular growth continued and a ANTRUM IS MADE ANTRUM FOLLICLE At this point granulosa cells form the corona radiata Still has a primary oocyte arrested in prophase one
46
Graafian follicle
Mature follicle 10 mm in diameter to 30 mm Largest secondary follicle Only 1 or 2 produces per month Ovulation next to come Will finish meiosis to become the secondary oocyte after ovulation
47
Secondary oocyte
Will form when the Graafian follicle ovulated the oocyte The oocyte will finish meiosis 1 and arrest at metaphase of meiosis 2
48
Granulosa lutein cells
Granulosa cells after ovulation will grow Form a blood clot Begin to produce progesterone
49
Theca lutein cells
Increase only slightly in size Come from theca interna Continue to produce estrogen
50
Corpus luteum
Made of granulosa lutein cells and theca lutein cells Basically a follicle after ovulation Initially a corpus hemorrhagicum= blood clot Degenerate in 10 days with no pregnancy Degenerates in 9 months with pregnancy
51
Uterine tube
Wall is folded mucosa and thick muscularis SM with serosa Simple columnar epithelium 2 cells: Ciliated columnar cells move oocyte Secretory cells- peg cells produce nutritive fluid covering epithelium
52
Uterus
``` 1. Perimetrium Outermost serosa or adventitia 2. Myometrium Middle smooth muscle 3. Endometrium -Simple columnar epithelium with ciliated and pegg cells -basal deep layer -functional layer handles ovarian hormones ```
53
Cervix
Narrow end of uterus ``` Endometrium differences: Not sloughed in menstration Contains cervical glands Transformation zone- simple columnar to non keritanized squamous =squamocolumnar junction ```
54
Vagina
Wall has mucosa, muscular, and adventitia Nonkeritanized stratified squamous Inner circular and out longitudinal muscle
55
Mammary glands
Modified tubuloaveolar sweat glands Secrete milk Merocrine and apocrine mechanisms