Endocrine System and Reproductive histology Flashcards
Hypothalamus
Main autonomic control center for the body, homeostasis
Regulates temp, food intake, water, sleep, behavior, endocrine
9 hormones
5 releasing hormones for anterior pituitary
2 inhibiting hormones for anterior pituitary
2 shipped and released by anterior pituitary
Pituitary gland
Hypophysis
Attached to hypothalamus via infundibulum
Sit on sella tunica of sphenoid bone or hypophyseal fossa
2 functional components
Anterior lobe: pars distalis, pars intermedia, pars tuberalis
Posterior lobe: pars NERVOSA and infundibulum
Pars distalis
Cords of epithelial cells interspersed with fenestrated capillaries
Pars intermedia
Basophilic cells produce MSH, melanocytes stimulating hormone
Surrounds a series of collided filled follicles that are residual lumen from Rathkes pouch
Pars tuberalis
Forms collar around infundibulum and has cells with basophils gonadotropic cells
Pars NERVOSA
Neurosecretory axons and their endings
Transport hormones from hypothalamus to posterior pituitary
HYPOTHALAMO-HYPOPHSYEAL TRACT
Fibroblasts, mast cells, and pituicytes (glial cell like astrocytes most abundant)
Hormones: OXYTOCIN AND ANTIDIURETIC HORMONE (vasopressin)
Hormones are stored in vesicles in dilated portions of axons near terminals HERRING BODIES, neurosecretory bodies
Herring bodies end in terminal buttons
Infundibulum
Bundle of axon from the hypothalamus
Contains neuroses retort axons forming the HYPOTHALAMO-HYPOPHSYEAL TRACT
Anterior pituitary hormones
Work in a negative feedback loop with the hypothalamus via the hypothalamo hypophyseal portal system
1. Chromophils- 50% of pars distalis hormones stored in cytoplasmic granules
A. Basophils 10%
B. Aciophils 40%
2. Chromophobes - 50% almost no granules so they are undifferentiated reserve cells
Hypothalamus hormones transport
Neurosectretory neurons send hormones
Travel into the hypophyseal portal system at primary plexus of the hypophyseal portal system (fenestrated capillaries)
Travel via the hypophyseal portal veins into the secondary plexus of the hypophyseal portal system
Bringing the hormones to the cells of the pars distalis
Anterior pituitary chromophil
HGH- somatotropes, acidophil
TSH- thyrotropes, basophils
FSH- gonadotropes, basophils
LH- gonadotropes, basophils
Prolactin PRL- lactotropes, acidophil
Adrenocortictrophic hormone ACTH- corticotropes, basophils
Melanocytes stimulating MSH- corticotropes, basophils
Anterior pituitary hormone function
HGH- IGF insulin like growth factor, growth
TSH- secretion of thyroid hormones
FSH- iniates oocyte development and ovarian secretion of estrogen. In males testes produce sperm
LH- stimulates estrogen, progesterone, ovulation, formation of corpus luteum. In males stimulates testosterone production
PRL- promotes milk
ACTH- gluccorticoids secretion
MSH- Unknown role but darkens skin
Posterior pituitary hormone function
Oxytocin OT- released in response to uterine distention, stimulates smooth muscles of uterus and mammary glands
ADH or vasopressin- released in response to high blood pressure, dehydration, loss of blood….conserves body water and decrease urine
Pineal gland
Hormone is melatonin, in Diencephalon Responsible for sleep cycle 2 cells Pinealocytes or parenchymal cells - 95% Interstitial cells- 5%
Characteristic presence of corpora arenacea or brain sand
Adrenal glands
Capsule around the gland
1. Cortex- large peripheral area 80% of gland, steroids
- Medulla- smaller area centrally located, catecholamine cells
Adrenal cortex
Zona glomerulosa- mineralcorticoids =aldosterone
Zona fasiculata- steroids, cortisol =glucocorticoid
Zona reticularis- androgens= gonadocorticoids
Adrenal medulla
Highly vascularized
Chromaffin cells
Epinephrine and norepinephrine = catecholamines
Small amount of dopamine
Receives preganglionic sympathetic axons straight to chromatic cells
-synapse directly on cells (different from every other)
Adrenal gland hormone function
Aldosterone- regulates water and ions for low blood pressure situations
Cortisol- regulates metabolism, suppresses immune, resistance to stress
Androgen- DHEA, early pubic growth
Catecholamines- intensify sympathetic response
Pancreas
Islets of langerhans
Beta cells- insulin
Alpha cells- glucagon
delta cells - somatostatin, or Growth hormone inhibiting hormone
Thyroid gland
Thyroid follicles surrounded by follicular cells (produce thyroglobulin or TGB)
T4- thyroxine
T3- Tri iodothyronine
Important in growth, cell differentiation, and metabolic rate
So increase oxygen consumption if metabolic increases
Make thyroglobulin as inactive form in the follicles
Parafollicular- C cells are large pale staining that produce calcitonin
CALCITONIN- decreases circulating calcium, increase osteoblasts
Parathyroid gland
2 cell types
Chief cells or principal cells- produce parathyroid hormone, small round cells central nucleus, larger amount
Oxyphil cells- larger cells very acidophilus, unknown function
PTH- increase calcium levels in the blood, increase ostesclasts
Components of male reproductive system
Testes
Passageways- straight tubules, rete testis, epidymis, vas deferens, ejectulatory duct, urethra, penis
-SREVEN UP
Accessory glands- seminal vesicles, prostate gland, bulbourethral gland
Penis
Testes function
Endocrine with testosterone
Exocrine with sperm or spermatogenesis
1. Spermatogonial phase- undergo mitosis to make spematocytes
2. Spermatocyte phase-undergo meiosis 1-2
3. Spermatid phase- maturation, tail and body formation
Seminiferous tubules
Lined with complex stratified epithelium Area is lined with sperm or sperm cells that are waiting maturation 1. Sertoli cells or supporting cells 2. Spermatogenesis cells - spermatogonia- 3 types -primary spermatocytes -secondary spermatocytes - spermatids
Testes layers
Tunica vaginalis Tunica albuginea Septums Seminiferous tubules Straight tubules Mediastinum testes RETE testis