Endocrine System Flashcards

0
Q

3 main hormone families and solubilities

A
Amine derived (water soluble)
Peptide hormones (water soluble)
Lipid phospholipid hormones (water insoluble)
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1
Q

What we need from this type of system

5 + eg

A
Specificity 
Only specific receptors 
High affinity for hormone
Integrated amplification system
Protective transport system eg albumin
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2
Q

Amine derived eg

A

Tyrosine
Histadine
Trypophane

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3
Q

Peptide hormone eg

A

TRH
Insulin
LH

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4
Q

Lipid hormones eg

A

Prostaglandins

Testosterone

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5
Q

Hormone receptor interaction

A

Defined by Kd

Dissociation constant

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6
Q

Conc of hormone is determined by 3 factors

A

Rate of release
Rate of delivery
Rate of degradation and elimination

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7
Q

Rate of release

A

Synthesis and secretion

Controlled by positive and negative feedback

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8
Q

Rate of delivery

A

High blood flow delivers more hormones

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9
Q

Rate of degradation

A

Short half life

Rapid removal

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10
Q

Hydrophilic hormone receptors.

A
Cell surface membrane 
Channel linked receptors 
Secondary messengers:
Enzyme receptors 
Tyrosine kinase
G-protein linked
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11
Q

Hydrophobic receptors

A

Cytoplasmic receptors

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