Endocrine system Flashcards
Endocrine system fxn
Responses usually slower and long-lasting (minutes to days)
Controls long-term processes - growth, metamorphosis, etc
Endocrine glands (6)
pituitary
thyroid
adrenal
pancreas
ovary
testicles
Two types of glands
exocrine and endocrine glands
exocrine glands
Have ducts for discharging onto a free surface - into the GI or somewhere outside the body
Endocrine glands
Small, well-vascularized, ductless glands that stay contained within the body
alpha cell
makes glucagon
beta cell
makes insulin
alpha and beta cells are where?
In the pancreas, and specifically in the islet of Langerhans
Acinar cell
make the pancreatic juice (enzymes)
What are hormones and how do they work?
Chemical messengers
Produced by an endocrine gland -> carried by blood to a target organ -> interact with target organs via receptors on/in the cells of those organs
Water-soluble hormones
Act through receptors on the cell membrane (protein hormones, amino acid derivatives)
Fat-soluble hormones
Act through nuclear or cytoplasmic receptors
(steroids such as estrogen and testosterone)
transmembrane proteins
embedded in the cell membrane ->
act as receptors for various things floating in the blood
Action via cell surface receptors
what kind?
Water-soluble hormone
1.) hormone diffuses out of capillary and binds to receptor in the cell membrane
2.) Binding triggers release of a second messenger
3.) second messenger triggers a series of reactions that alter the physiology of the cell
Action via cytoplasmic or nuclear receptors
what kind?
Fat-soluble hormones
hormone binds to receptor located in nucleus or cytoplasm
Receptor-hormone complex binds to DNA and turns on one or more genes
Activated genes direct synthesis of new proteins