ENDOCRINE QUIZ Flashcards
This gene is considered the prophet of PIT
A. PTX 2
B. POU1F1
C. PROP1
D. POU1F2
C. PROP1
It is the most common recessive form of Multiple Pituitary Hormone Deficiency (MPHD).
A. Mutations in PTX2
B. Mutations in PROP1
C. Mutations in POU1F1
D. Mutations in POU1F2
B. Mutations in PROP1
It is a nuclear protein that binds to the GH and PRL promoters
A. LHX3
B. PTX2
C. PROP1
D. POU1F1
D. POU1F1
GH1 gene is one of a cluster of 5 genes on this chromosome.
A. Chr 17q22-24
B. Chr 17q21-23
C. Chr 17q22-25
D. Chr. 17q21-24
A. Chr 17q22-24
The definitive diagnosis of growth
hormone deficiency is the demonstration of:
A. High levels of IGF1
B. High levels of GH
C. Low levels of GH
D. Low levels of IGF1
C. Low levels of GH
The maximum of days of estrogen priming needed prior to GH testing to achieve greater diagnostic specificity is:
A. 2 days
B. 3 days
C. 4 days
D. 5 days
B. 3 days
It is the hormone involved in Diabetes
Insipidus.
A. Desmopressin
B. Pitressin
C. Vasopressin
D. ACTH
C. Vasopressin
Extracellular fluid volume is regulated by this mechanism.
A. K intake and secretion
B. K intake and excretion
C. Na intake and secretion
D. Na intake and excretion
D. Na intake and excretion
Vasopressin release is stimulated by this process:
A. Dec in plasma tonicity
B. Inc in plasma tonicity
C. Dec in urine volume
D. Inc in urine volume
B. Inc in plasma tonicity
The diagnosis of diabetes insipidus is
established when:
A. Serum osmolality is > 200, urine
osmolality is < 200
B. Serum osmolality is > 300, urine
osmolality is > 300
C. Serum osmolality is < 200, urine
osmolality is > 200
D. Serum osmolality is >300, urine
osmolality is < 300
D. Serum osmolality is >300, urine
osmolality is < 300
This results in defects in the aquaporin-2 gene.
A. Congenital autosomal recessive NDI
B. Congenital autosomal dominant NDI
C. Congenital X-linked NDI
D. Congenital hypopituitarism
A. Congenital autosomal recessive NDI
Atrial natriuretic peptide (ANP) has a
number of effects on salt and water
balance such as:
A. Inhibition of natriuresis
B. Inhibition of Na resorption
C. Inhibition of K resorption
D. Stimulation of vasopressin
secretion
B. Inhibition of Na resorption
A water deprivation test is indicated when pathologic polyurua and polydipsia are president and serum osmolality is:
A. >250mOsm/kg, < 300mOsm/kg
B. >260mOsm/kg, < 300mOsm/kg
C. > 270mOsm/kg, < 300mOsm/kg
D. >270mOsm/kg, >300mOsm/kg
C.
>270mOsm/kg, < 300mOsm/kg
Mutations in this gene cause septo-optic dysplasia:
A. HESX1
B. LHX3
C. LHX4
D. PTX
A. HESX1
The gene that is also referred as RIEG1 is called:
A. PTX1
B. PTX2
C. LHX3
D. LHX4
B. PTX2
When a person consumes more than 2L per day, he would have increased urine output and the serum Na would be:
A. Normal
B. Dec
C. Inc
D. Absent
B. Dec
A persons with hypotonic fluid overload would have a serum Na of:
A. < 125 meq/L
B. < 130 meq/L
C. < 135 meq/L
D. < 140 meq/L
C. < 135 meq/L
Rapid correction of a person with serum of 115 meq/L will cause:
A. Lateral pontine myelinosis
B. Cerebral salt wasting
C. Central cerebellar myelinolysis
D. Central pontine myelinolysis
D. Central pontine myelinolysis
The gold standard for diagnosis of tall
stature is:
A. MRI
B. IV glucose challenge test
C. IGF-1 challenge test
D. Oral Glucose challenge test
D. Oral Glucose challenge test
A syndrome characterized by large
tongue, pancreatic B-cell hyperplasia,
enlarged liver is:
A. Reiger syndrome
B. Beckwith-weidmann syndrome
C. McCune albright syndrome
D. Sotos syndrome
B. Beckwith-weidmann syndrome
This gene turns on POUF1 expression and is called the prophet of PIT1
A. PROP1
B. PROP2
C. PTX1
D. PROP
A. PROP1
This syndrome is caused by mutations in the PTX2 transcription gene.
A. Hall-Pallister syndrome
B. Hypogammaglobulinemia
C. Reiger syndrome
D. Ritter’s syndrome
C. Reiger syndrome
The most common cause for recessive
multiple pituitary hormone deficiency is mutations of this gene:
A. HESX1
B. LHX3
C. PTX2
D. PROP1
D. PROP1
This gene is expressed in precursor cell of all 5 cell types of the early embryologic development of the pituitary gland.
A. LHX3
B. LHX4
C. HESX1
D. PTX2
C. HESX1
It is nuclear protein that binds to the
growth hormone and prolactin promoters
A. PTX2
B. PTX3
C. PIT1
D. PROP1
C. PIT1
The GH1 gene is one of a cluster of 5 genes on chromosome
A. 17q 21-24
B. 17q 22-24
C. 17q 23-25
D. 17q 22-24
D. 17q 22-24
The half life of vasopressin in the
circulation is:
A. 3 minutes
B. 4 minutes
C. 5 minutes
D. 6 minutes
C. 5 minutes
It is a 9-aminopeptide antidiuretic and has vascular pressor activity synthesized in the hypothalamus.
A. Desmopressin
B. Vasopressin
C. Pitressin
D. dDAVP
B. Vasopressin
A 10-year old obese has polyuria,
polydipsia and hyperpigmentation of the skin and back sought consult. FBS is high at 190pmg/dL with high insulin levels. Your most likely diagnosis is:
A. Type 1 DM
B. Type 2 DM
C. Cushing’s syndrome
D. Hypercortisolism
B. Type 2 DM
Congenital X-linked Nephrogenic Diabetes Insipidus (NDI) results from mutations in gene/recptor:
A. Aquaporin-1 gene
B. Aquaporin-2 gene
C. Vasopressin V1 receptor
D. Vasopressin V2 receptor
D. Vasopressin V2 receptor
Congenital autosomal recessive NDI
results from mutations in:
A. Aquaporin-1 gene
B. Aquaporin-2 gene
C. Vasopressin V1 receptor
D. Vasopressin V2 receptor
B. Aquaporin-2 gene
In systemic dehydration, the intravascular volume characterized as:
A. Low
B. Normal
C. High
D. Very high
A. Low
In cerebral salt wasting, vasopressin level is characterized as:
A. Low
B. Normal
C. High
D. Very high
A. Low
It is an autosomal dominant connective
tissue disorder characterized by increased arm span.
A. Klinefelter syndrome
B. XYY syndrome
C. Marfan syndrome
D. Turners syndrome
C. Marfan syndrome
The most common brain lesion causing
true precocious puberty is:
A. Prolactinoma
B. Craniopharyngioma
C. Hypothalamic hamartomas
D. Corticoprolactinoma
C. Hypothalamic hamartomas
The most common cause of infants who are large for gestational age is:
A. Maternal Diabetes Mellitus
B. Weaver syndrome
C. Hyperthyroidism
D. Cerebral gigantism
A. Maternal Diabetes Mellitus
An autosomal recessive inborn error of
amino acid metabolism causing mental
retardation and resembles Marfan
syndrome is:
A. SHOX excess syndromes
B. Weaver syndrome
C. Homocystinuria
D. Fragile X syndrome
C. Homocystinuria
The cardinal clinical feature of gigantism includes:
A. Longitudinal growth acceleration
B. Coarse facial features
C. Enlarging hands and feet
D. Visual problems
A. Longitudinal growth acceleration
In young persons with open epiphysis,
overproduction of growth hormone
results in:
A. Acromegaly
B. Gigantism
C. Klinefelter syndrome
D. Sotos syndrome
B. Gigantism
The most common tumors of the pituitary in adolescents are:
A. Corticoprolactinoma
B. Prolactinoma
C. Corticotropinomas
D. Craniopharyngiomas
B. Prolactinoma
The most common adenomas seen
prepubertally are:
A. Corticoprolactinoma
B. Prolactinoma
C. Corticotropinomas
D. Craniopharyngiomas
B. Prolactinoma
The following are TRUE of Type 1 Diabetes Mellitus, EXCEPT:
A. Due damage to pancreativc B cells
B. Also called juvenile diabetes
C. Development of ketoacidosis is
frequent
D. Occurs predominantly in adults
D. Occurs predominantly in adults
The following statements are TRUE about Type 2 Diabetes Mellitus, EXCEPT:
A. Non-insulin dependent diabetes
B. Noted peripheral insulin
resistance
C. With absolute insulin deficiency
D. non-autoimmune destruction of B
cells
C. With absolute insulin deficiency
This is the end result of metabolic
abnormalities from a severe insulin
deficiency or insulin effectiveness.
A. Hyperglycemia
B. Ketoacidosis
C. Metabolic alkalosis
D. Pheochromocytoma
B. Ketoacidosis
This is the major cause of morbidity and mortality in children with Type 1 Diabetes mellitus.
A. Ketoacidosis
B. Cerebral edema
C. Hyperglycemia
D. Nonketotic Hyperosmolar coma
B. Cerebral edema
A well 11-year old female sought consult due to short stature. Family history showed a few short maternal aunts. which is the most likely test that will help you with your diagnosis?
A. Bone aging
B. Thyroid hormone tests
C. Serum cortisol levels
D. Serum insulin levels
A. Bone aging
Syndrome of inappropriate antidiuretic
hormone secretion is characterized by
hyponatremia and an inappropriately
concentrated urine mOsm/kg value of:
A. > 100
B. > 200
C. > 300
D. > 400
A. > 100
Infants with congenital defects of the
pituitary and hypothalamus usually
present with the following characteristics, EXCEPT:
A. Apnea
B. Cyanosis
C. Jaundice
D. Hyperglycemia
D. Hyperglycemia
Chronic SIADH is BEST treated with one of the following:
A. Diuretics
B. Oral fluid restriction
C. Demeclocycline
D. Sodium supplementation
B. Oral fluid restriction
The classic manifestations of polyuria,
polydipsia, optic atrophy, and brain
abnormalities characterize this disorder
A. Hyponatremia
B. Diabetes insipidus
C. Cerebral salt wasting
D. Syndrome of Inappropriate
Antidiuretic Hormone
B. Diabetes insipidus
