Endocrine/Pancreas - Exam 3 Flashcards
exocrine
majority, acinar cells and duct cells, GI function, secrete enzymes into the lumen of the duodenum
endocrine
islets of langerhans
endocrine cell types
beta, alpha, delta, F
alpha cell
glucagon
delta cell
somatostatin - inhibitor of insulin secretion
beta cell
insulin
F cell
pancreatic polypeptide
insulin secreted in response to
hyperglycemia, synthesized as a larger molecule inside Golgi and packaged into secretory granules awing secretion, release contents via exocytosis, then goes to circulation
GLUT2
allows insulin to diffuse freely into the cell, make ATP, voltage gated calcium channels, insulin exocytosis, binds to receptor tyrosine kinase
increase in blood glucose =
insulin secretion
insulin sensitive tissues
liver, muscle, fat, GLUT4
liver insulin sensitive
increase glycogen synthesis, increase lipogenesis
muscle insulin sensitive
increase glucose transport, increase glycogen synthesis, increase amino acid uptake, increase protein synthesis
fat insulin sensitive
increase glucose transport, increase glycogen synthesis, increase lipogenesis
counter regulatory hormones
glucagon (alpha), epinephrine (medulla), cortisol (cortex), growth hormone (adenohypophysis)