Endocrine Dysfunction Flashcards

1
Q

What cause endocrine disease

A

Overproduction of hormone (tumour)
Underproduction of a hormone (destruction of endocrine tissue)
Malfunctioning receptors
Hormonal pathway disrupted

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2
Q

What is a primary endocrine disease

A

An issue with the endocrine organ itself

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3
Q

What is Cushing disease

A

Hyperadrenocorticism - excessive cortisol production

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4
Q

What are the 2 categories in Cushing disease

A

Pituitary dependent - excessive ACTH
Adrenal dependent - usually due to adenocarcinomas

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5
Q

What is iatrogenic hyperadrencorticism

A

Excess exogenous administration of cortisol

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6
Q

What are the functions of cortisol

A

Metabolic effects: gluconeogenisis
Lipolysis
Protein degradation
Na/ Water retention
PTH release
Osteoclast activity
Inhibit FSH, LH, TSH, GH release
Inhibit calcium re absorption
Suppresses immune system

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7
Q

What is Addison’s disease

A

Hypoadrenocorticism

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8
Q

What are the signs of hypoadrenocorticism

A

Weight loss
Hypoglycaemic
Hyperpigmentation - due to High ACTH

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9
Q

What is the function of Parathyroid hormone

A

Cause calcium mobilisation from bone when blood Ca levels are low
And calcium re absorption from the DCT

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10
Q

What causes primary hyperparathyroidism

A

Tumours in the parathyroid gland

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11
Q

What causes secondary hyperparathyroidism

A

Chronic renal disease

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12
Q

What causes hypoparathyroidism

A

Iatrogenic removal of parathyroid gland

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13
Q

What is panhypopituitarism

A

Reduction in pituitary hormone due to a tumour inflammation that destroys tissue.

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14
Q

What is Equine Cushing’s disease

A

Pituitary Pars Intermedia Dysfunction
(Increased secretion of hormones, but mainly ACTH)

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