Endocrine Drugs Flashcards
Differentiate Wolf-Chaikoff effect from Job-Basedow phenomenon.
Wolf-Chaikoff effect: ingestion of iodine causes hypothyroidism
Job-Basedow phenomenon: ingestion if iodine causes hyperthyroidism
Which antithyroid drug inhibit peripheral conversion to T4 to T3?
Propylthiouracil
Propranolol
Hydrocortisone
What drug can cause drug-induced hyperthroidism?
Clofibrate
Amiodarone
Methadone
Addison VS Conn
Addison's = Adrenal insufficiency Conn's = adrenal exCess
Mnemonics-Progestins
NORgestimate, NORerthindrone and NORgestrel are NOT ESTROGENS. They are PROGESTINS!
Mnemonics-Tamoxifen
TAnggal Mammary Mo = TAMOxifen
Mnemonics-Clomiphene
Clone Me Phlease = Clomiphene
Mnemonics-Flutamide
Flutamide = Fake Androgen
Mnemonics-Flutamide
FinAsteRIde = Five Alpha Reductase Inhibitor
Mnemonics-Insulin Preparations
LISpro = mabiLIS gLARGine = Go Large! LANTus = LANTa na sa sobrang tagal!
Why is there paradoxical improvement of diabetes in patients with end-stage renal disease?
insulin has prolonged half life due to decreased clearance
Which patients are more prone to developing hypoglycemia with insulin use?
advanced renal disease
elderly
children younger than 7 years
Why are the only routes of administration for insulin subcutaneous and IV?
TRANSDERMAL –> does not result in a reproducible and sufficient transfer of insulin across the skin
ORAL –> lack of a specific peptide carrier system in the gut
INTRANASAL –> bioavailability was low ang metabolic effect lasted too short to be of clinical usefulness
INTRAMASCULAR –> overall metabolic response not comparable to SC
INHALATION –> most promising; comparable to SC and IV but is still presently in Phase III trials (Exubera)
Mnemonics-Pioglitazone
PIOGlitazone = pampa-POGI ng INSULIN para di mo na ma-resist
Are BANGKOK PILLS safe for weight loss?
BANGKOK PILLS
ephedrine, fenfluramine, phentermine
adverse effect: valvular heart disease
